Ergotamine
Name: Ergotamine
- Ergotamine drug
- Ergotamine ergotamine drug
- Ergotamine used to treat
- Ergotamine is used to treat
- Ergotamine side effects
- Ergotamine effects of ergotamine
- Ergotamine names
- Ergotamine tablet
Warnings
Black Box Warnings
Serious and/or life threatening peripheral ischemia has been reported with coadministration of this drug with potent CYP 3A4 inhibitors (including protease inhibitors and macrolide antibiotics). Because CYP3A4 inhibition elevates the serum levels of ergotamine, the risk of vasospasm leading to cerebral ischemia and/or ischemia of the extremities is increased. Concurrent use of these drugs is contraindicated.
Contraindications
Hypersensitivity, PVD, CAD, Raynaud's phenomenon, pregnancy/lactation, sepsis, impaired renal or hepatic function, malnutrition, severe HTN
Concomitant strong CYP3A4 inhibitors
Cautions
Should be initiated at first sign of vascular headache
Ineffective for muscle contraction headache
Discontinue if S/S of impaired circulation
Possibility of retroperitoneal and pleuropulmonary fibrosis; paresthesia; GI disturbance; chest pain
May exacerbate heart failure
Safety/efficacy not established for peds
Many brands discontinued
Ergotamine Drug Class
Ergotamine is part of the drug class:
Ergot alkaloids
Uses of Ergotamine
- It is used to treat migraine headaches.
What are some other side effects of Ergotamine?
All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:
- Upset stomach or throwing up.
These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.
You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.
Brand Names U.S.
- Ergomar
Use Labeled Indications
Vascular headache: Abort or prevent vascular headaches, such as migraine, migraine variants, or so-called “histaminic cephalalgia”
Contraindications
Hypersensitivity to ergotamine or any component of the formulation; peripheral vascular disease; hepatic or renal impairment; coronary artery disease; hypertension; sepsis; ergot alkaloids are contraindicated with strong inhibitors of CYP3A4 (includes protease inhibitors, azole antifungals, and some macrolide antibiotics); pregnancy
Administration
Do not crush sublingual tablets..
Liver Dose Adjustments
Ergotamine is contraindicated in patients with impaired hepatic function.
Precautions
Consult WARNINGS section for dosing related precautions.