Enbrel (Etanercept Prefilled Syringes)

• It is used to treat rheumatoid arthritis.
• It is used to treat juvenile arthritis.
• It is used to treat psoriatic arthritis.
• It is used to treat ankylosing spondylitis.
• It is used to treat plaque psoriasis.
• It may be given to you for other reasons. Talk with the doctor.

• Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• Hepatitis B testing may be done. A hepatitis B infection may get worse during care.
• You may have more chance of getting an infection. Wash hands often. Stay away from people with infections, colds, or flu.
• Talk with your doctor before getting any vaccines. Use with Enbrel may either raise the chance of an infection or make the vaccine not work as well.
• Make sure you are up to date with all your vaccines before treatment with this medicine.
• Do not get a weakened bacteria like BCG for bladder cancer while you use Enbrel. Talk with your doctor.
• If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
• There is a chance of skin cancer. Avoid sun, sunlamps, and tanning beds. Use sunscreen and wear clothing and eyewear that protects you from the sun.
• Have your skin checked. Tell your doctor if you have any skin changes like a new wart, skin sore or reddish bump that bleeds or does not heal, or a change in the color or size of a mole.
• You may bleed more easily. Be careful and avoid injury. Use a soft toothbrush and an electric razor.
• Very bad and sometimes deadly problems like low white blood cell counts, aplastic anemia, and other blood problems have happened with this drug. Talk with the doctor.
• If you are 65 or older, use this medicine with care. You could have more side effects.
• Use with care in children. Talk with the doctor.
• If giving to your child, the dose of Enbrel may need to be changed as your child's weight changes. Have your child's weight checked often. Talk with the doctor before changing your child's dose.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
• If you used Enbrel (etanercept prefilled syringes) when you were pregnant, tell your baby's doctor.
• Tell your doctor if you are breast-feeding. You will need to talk about any risks to your baby.
• If you have a latex allergy, talk with your doctor.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Irritation where the shot is given.
• Loose stools (diarrhea).
• Headache.
• Runny nose.
• Stuffy nose.
• Throat irritation.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• Store in a refrigerator. Do not freeze.
• If needed, you may store at room temperature for up to 14 days. Write down the date you take Enbrel out of the refrigerator. If stored at room temperature and not used within 14 days, throw this medicine away.
• Do not put Enbrel back in the refrigerator after it has been stored at room temperature.
• Store in original container.
• Protect from light.
• Protect from very hot or very cold temperatures.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.