Endo-Mectin

Ivermectin lotion is a no-comb,10-minute prescription treatment used to treat head lice infestations in adults and children 6 months of age and older.

Ivermectin is also available in tablet form. It is a prescription medication used to treat two types of roundworm parasites. It is usually taken as a single dose on an empty stomach with water.

Ivermectin is also available in a topical cream that is used to treat rosacea.

Ivermectin belongs to a group of drugs called antihelmintics. It works by killing the target parasite.

Common side effects of ivermectin lotion include eye redness and irritation, dandruff, and dry skin.

Common side effects of ivermectin tablets include loss of appetite, nausea, vomiting, and dizziness. Do not drive or operate heavy machinery until you know how this medication affects you.

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of ivermectin lotion and tablets, there are no specific foods that you must exclude from your diet.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Oral:

• Store tablets at room temperature and away from excess heat and moisture (not in the bathroom).
• Keep ivermectin tablets and all medicines out of reach of children.

Topical:

• Store ivermectin lotion at room temperature between 68° to 77°F (20° to 25°C).
• Do not freeze ivermectin lotion.
• Safely throw away any unused ivermectin lotion.
• Keep ivermectin lotion and all medicines out of reach of children.

Injection for Cattle and Swine

ANADA 200-437, Approved by the FDA

A Parasiticide for the Treatment and Control of Internal and External Parasites of Cattle and Swine.

Consult your veterinarian for assistance in the diagnosis, treatment and control of parasitism.

Ivermectin is derived from the avermectins, a family of potent, broadspectrum antiparasitic agents isolated from fermentation of Streptomyces vermitilis.

Endo-Mectin® Injection is a clear, ready-to-use, sterile solution containing 1% ivermectin, 40% glycerol formal, and propylene glycol q.s. ad 100%. Endo-Mectin® Injection is formulated to deliver the recommended dose level of 200 mcg ivermectin/kilogram of body weight in cattle when given subcutaneously at the rate of 1 mL/110 lb (50 kg). In Swine, Endo-Mectin® Injection is formulated to deliver the recommended dose level of 300 mcg ivermectin/kilogram body weight when given subcutaneously in the neck at the rate of 1 mL per 75 lb (33 kg).

Ivermectin is a member of the macrocyclic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells. This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand-gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocyclic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

Cattle: Endo-Mectin® Injection should be given only by subcutaneous injection under the loose skin in front of or behind the shoulder at the recommended dose level of 200 mcg of ivermectin per kilogram of body weight. Each mL of Endo-Mectin® Injection contains 10 mg of ivermectin, sufficient to treat 110 lb (50 kg) of body weight (maximum 10 mL per injection site).

Swine: Endo-Mectin® Injection should be given only by subcutaneous injection in the neck of swine at the recommended dose level of 300 mcg of ivermectin per kilogram (2.2 lb) of body weight. Each mL of Endo-Mectin® Injection contains 10 mg of ivermectin, sufficient to treat 75 lb of body weight.