Emend 3-Day

You should not use aprepitant if you are allergic to it, or if you take another medicine called pimozide (Orap). Aprepitant can cause unwanted or dangerous effects when used with pimozide.

To make sure aprepitant is safe for you, tell your doctor if you have:

• liver disease.

It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.

Aprepitant can make birth control pills less effective. Ask your doctor about using a non-hormonal birth control (condom, diaphragm with spermicide) to prevent pregnancy, and for 1 month after your last dose.

It is not known whether aprepitant passes into breast milk or if it could harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Aprepitant is not for long-term use. For use in chemotherapy, you will most likely need only 3 separate doses. When used before surgery, you will likely receive only 1 dose.

The first dose of aprepitant is usually taken 1 hour before treatment with chemotherapy, or 3 hours before a surgery. Follow your doctor's dosing instructions very carefully.

You may also be given other medicines with aprepitant to further help prevent nausea and vomiting.

Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.

Aprepitant can be taken with or without food. If you take aprepitant before surgery, follow your doctor's instructions about any restrictions on food or beverages.

Do not crush, chew, break, or open an aprepitant capsule. Swallow it whole.

Give the oral suspension (liquid) using only the dosing syringe provided.

Do not share this medicine with another person. Aprepitant should not be used to treat general nausea that is unrelated to chemotherapy or surgery.

If you also take warfarin (Coumadin, Jantoven), you may need extra "INR" or prothrombin time tests after you have taken aprepitant.

Store aprepitant capsules at room temperature away from moisture and heat.

Store the prefilled liquid dosing syringe in the refrigerator, do not freeze. After taking the liquid out of the refrigerator, you must use it within 3 hours.

Throw away any liquid medicine not used within 3 days (72 hours) after you received it. Do not save it for later use.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Follow your doctor's instructions about any restrictions on food, beverages, or activity.

Get emergency medical help if you have signs of an allergic reaction: hives, rash, itching, skin sores or peeling; warmth or tingly feeling; trouble breathing or swallowing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• a light-headed feeling, like you might pass out;

• low blood cell counts--fever, chills, flu-like symptoms, swollen gums, mouth sores, skin sores, rapid heart rate, pale skin, easy bruising, unusual bleeding; or

• dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.

Common side effects may include:

• stomach pain, indigestion, loss of appetite;

• diarrhea, constipation;

• hiccups;

• abnormal liver function tests;

• headache, dizziness;

• cough; or

• feeling weak or tired.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.