Divalproex Sodium

• Before you start the treatment, read the manufacturer's printed information leaflet from inside the pack. It will give you more information about your medicine and it will provide you with a full list of the side-effects which you may experience from taking it.
• Take divalproex sodium exactly as your physician tells you to. Your dose will be printed on the label of the pack to remind you about what the physician has said.
• Your dose of divalproex sodium will depend on the reason you are taking it, your age and your body weight. Your physician will usually prescribe a lower dose to start with and then ask you to increase the dose over a few days. This helps you find the dose that controls your symptoms whilst keeping side-effects to a minimum.
• Extended release tablets are usually taken once a day. Capsules and delayed release tablets are usually taken two or three times a day.
• Divalproex sodium should be taken with food, so take your doses with a snack or just after you have had a meal.
• If you have been given delayed or extended release tablets, swallow them whole with a drink of water. Do not chew or crush the tablets because they have a special protective coating.
• Some brands of capsules (eg, Depakote® Sprinkles) can be opened and the contents mixed with a soft food such as applesauce. Carefully open the capsule and pour the entire contents onto a spoonful of applesauce. This should then be swallowed without chewing the granules or pellets.
• Try to get into a habit of taking the tablets at the same times each day. This will help you avoid missing any doses.
• If you do forget to take a dose, take it as soon as you remember unless it is nearly time for your next dose, in which case leave out the missed dose. Do not take two doses together to make up for a forgotten dose.

Do not take more or less of this medication than your doctor prescribed. Always follow the dosing label to get the best results.

Your dose will depend on your condition and what works for you. Your doctor may change your dose occasionally to make sure you are getting the best results.

Do not crush or chew Depakote tablets or Depakote ER tablets. Swallow them whole.

Depakote Sprinkle Capsules may be swallowed whole, or broken open and sprinkled on a small amount of soft food like applesauce or pudding.

Once you have mixed the contents of the capsule with food it must be taken immediately; you can't save the dose for later.

Consider wearing a medic alert tag or carrying an ID card letting emergency healthcare providers know that you're on a seizure medication.

Drink plenty of water when you're taking this drug, your doctor may change your dose if you are not getting enough fluids.

Depakote Withdrawal

Do not stop taking Depakote without talking to your healthcare provider first. Stopping a seizure medication like Depakote suddenly can cause serious withdrawal symptoms or other problems. 

In a patient who has epilepsy, quitting abruptly can cause seizures that will not stop (status epilepticus).

Depakote Overdose

If you suspect you've overdosed on this medication, seek emergency medical attention or call a poison help line at (800) 222-1222.

If you miss a dose, take the missed dose as soon as you remember.

Skip the missed dose if it is almost time for your next scheduled dose.

Do not "double up" on this medication to make up for a missed dose.

Included as part of the PRECAUTIONS section.

DEPAKOTE ER
(dep-a-kOte)
 (divalproex sodium) Extended Release Tablets

DEPAKOTE
(dep-a-kOte)
 (divalproex sodium) Tablets

DEPAKOTE
(dep-a-kOte)
 (divalproex sodium delayed release capsules) Sprinkle Capsules

DEPAKENE
(dep-a-keen)
(valproic acid) Capsules and Oral Solution

Read this Medication Guide before you start taking Depakote or Depakene and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or treatment.

What is the most important information I should know about Depakote and Depakene?

Do not stop taking Depakote or Depakene without first talking to your healthcare provider.

Stopping Depakote or Depakene suddenly can cause serious problems.

Depakote and Depakene can cause serious side effects, including:

1. Serious liver damage that can cause death, especially in children younger than 2 years old. The risk of getting this serious liver damage is more likely to happen within the first 6 months of treatment.

Call your healthcare provider right away if you get any of the following symptoms:

• nausea or vomiting that does not go away
• loss of appetite
• pain on the right side of your stomach (abdomen)
• dark urine
• swelling of your face
• yellowing of your skin or the whites of your eyes In some cases, liver damage may continue despite stopping the drug.

2. Depakote or Depakene may harm your unborn baby.

• If you take Depakote or Depakene during pregnancy for any medical condition, your baby is at risk for serious birth defects that affect the brain and spinal cord and are called spina bifida or neural tube defects. These defects occur in 1 to 2 out of every 100 babies born to mothers who use this medicine during pregnancy. These defects can begin in the first month, even before you know you are pregnant. Other birth defects that affect the structures of the heart, head, arms, legs, and the opening where the urine comes out (urethra) on the bottom of the penis can also happen.
• Birth defects may occur even in children born to women who are not taking any medicines and do not have other risk factors.
• Taking folic acid supplements before getting pregnant and during early pregnancy can lower the chance of having a baby with a neural tube defect.
• If you take Depakote or Depakene during pregnancy for any medical condition, your child is at risk for having a lower IQ.
• There may be other medicines to treat your condition that have a lower chance of causing birth defects and decreased IQ in your child.
• Women who are pregnant must not take Depakote or Depakene to prevent migraine headaches.
• All women of child-bearing age should talk to their healthcare provider about using other possible treatments instead of Depakote or Depakene. If the decision is made to use Depakote or Depakene, you should use effective birth control (contraception).
• Tell your healthcare provider right away if you become pregnant while taking Depakote or Depakene. You and your healthcare provider should decide if you will continue to take Depakote or Depakene while you are pregnant.
  Pregnancy Registry: If you become pregnant while taking Depakote or Depakene, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. You can enroll in this registry by calling 1-888-233-2334. The purpose of this registry is to collect information about the safety of antiepileptic drugs during pregnancy.

3. Inflammation of your pancreas that can cause death.

Call your healthcare provider right away if you have any of these symptoms:

• severe stomach pain that you may also feel in your back
• nausea or vomiting that does not go away

4. Like other antiepileptic drugs, Depakote or Depakene may cause suicidal thoughts or actions in a very small number of people, about 1 in 500.

Call a healthcare provider right away if you have any of these symptoms, especially if they are new, worse, or worry you:

• thoughts about suicide or dying
• attempts to commit suicide
• new or worse depression
• new or worse anxiety
• feeling agitated or restless
• panic attacks
• trouble sleeping (insomnia)
• new or worse irritability
• acting aggressive, being angry, or violent
• acting on dangerous impulses
• an extreme increase in activity and talking (mania)
• other unusual changes in behavior or mood

How can I watch for early symptoms of suicidal thoughts and actions?

• Pay attention to any changes, especially sudden changes in mood, behaviors, thoughts, or feelings.
• Keep all follow-up visits with your healthcare provider as scheduled.

Call your healthcare provider between visits as needed, especially if you are worried about  symptoms.

Do not stop Depakote or Depakene without first talking to a healthcare provider. Stopping Depakote or Depakene suddenly can cause serious problems. Stopping a seizure medicine suddenly in a patient who has epilepsy can cause seizures that do not stop (status epilepticus).

Suicidal thoughts or actions can be caused by things other than medicines. If you have  suicidal thoughts or actions, your healthcare provider may check for other causes.

What are Depakote and Depakene?

Depakote and Depakene come in different dosage forms with different usages.

Depakote Tablets and Depakote Extended Release Tablets are prescription medicines used:

• to treat manic episodes associated with bipolar disorder.
• alone or with other medicines to treat:
  • complex partial seizures in adults and children 10 years of age and older
  • simple and complex absence seizures, with or without other seizure types
• to prevent migraine headaches

Depakene (solution and liquid capsules) and Depakote Sprinkles are prescription medicines used alone or with other medicines, to treat:

• complex partial seizures in adults and children 10 years of age and older
• simple and complex absence seizures, with or without other seizure types

Who should not take Depakote or Depakene?

Do not take Depakote or Depakene if you:

• have liver problems
• have or think you have a genetic liver problem caused by a mitochondrial disorder (e.g. Alpers-Huttenlocher syndrome)
• are allergic to divalproex sodium, valproic acid, sodium valproate, or any of the ingredients in Depakote or Depakene. See the end of this leaflet for a complete list of ingredients in Depakote and Depakene.
• have a genetic problem called urea cycle disorder
• are pregnant for the prevention of migraine headaches

What should I tell my healthcare provider before taking Depakote or Depakene?

Before you take Depakote or Depakene, tell your healthcare provider if you:

• have a genetic liver problem caused by a mitochondrial disorder (e.g. Alpers-Huttenlocher syndrome)
• drink alcohol
• are pregnant or breastfeeding. Depakote or Depakene can pass into breast milk. Talk to your healthcare provider about the best way to feed your baby if you take Depakote or Depakene.
• have or have had depression, mood problems, or suicidal thoughts or behavior
• have any other medical conditions

Tell your healthcare provider about all the medicines you take, including prescription and non-prescription medicines, vitamins, herbal supplements and medicines that you take for a short period of time.

Taking Depakote or Depakene with certain other medicines can cause side effects or affect how well they work. Do not start or stop other medicines without talking to your healthcare provider.

Know the medicines you take. Keep a list of them and show it to your healthcare provider and pharmacist each time you get a new medicine.

How should I take Depakote or Depakene?

• Take Depakote or Depakene exactly as your healthcare provider tells you. Your healthcare provider will tell you how much Depakote or Depakene to take and when to take it.
• Your healthcare provider may change your dose.
• Do not change your dose of Depakote or Depakene without talking to your healthcare provider.
• Do not stop taking Depakote or Depakene without first talking to your healthcare provider. Stopping Depakote or Depakene suddenly can cause serious problems.
• Swallow Depakote tablets, Depakote ER tablets or Depakene capsules whole. Do not crush or chew Depakote tablets, Depakote ER tablets, or Depakene capsules. Tell your healthcare provider if you cannot swallow Depakote or Depakene whole. You may need a different medicine.
• Depakote Sprinkle Capsules may be swallowed whole, or they may be opened and the contents may be sprinkled on a small amount of soft food, such as applesauce or pudding. See the Patient Instructions for Use at the end of this Medication Guide for detailed instructions on how to use Depakote Sprinkle Capsules.
• If you take too much Depakote or Depakene, call your healthcare provider or local Poison Control Center right away.

What should I avoid while taking Depakote or Depakene?

• Depakote and Depakene can cause drowsiness and dizziness. Do not drink alcohol or take other medicines that make you sleepy or dizzy while taking Depakote or Depakene, until you talk with your doctor. Taking Depakote or Depakene with alcohol or drugs that cause sleepiness or dizziness may make your sleepiness or dizziness worse.
• Do not drive a car or operate dangerous machinery until you know how Depakote or Depakene affect you. Depakote and Depakene can slow your thinking and motor skills.

What are the possible side effects of Depakote or Depakene?

• See “What is the most important information I should know about Depakote or Depakene?”

Depakote or Depakene may cause other serious side effects including:

• Bleeding problems: red or purple spots on your skin, bruising, pain and swelling into your joints due to bleeding or bleeding from your mouth or nose.
• High ammonia levels in your blood: feeling tired, vomiting, changes in mental status.
• Low body temperature (hypothermia): drop in your body temperature to less than 95°F, feeling tired, confusion, coma.
• Allergic (hypersensitivity) reactions: fever, skin rash, hives, sores in your mouth, blistering and peeling of your skin, swelling of your lymph nodes, swelling of your face, eyes, lips, tongue, or throat, trouble swallowing or breathing.
• Drowsiness or sleepiness in the elderly. This extreme drowsiness may cause you to eat or drink less than you normally would. Tell your doctor if you are not able to eat or drink as you normally do. Your doctor may start you at a lower dose of Depakote or Depakene.

Call your healthcare provider right away, if you have any of the symptoms listed above.

The common side effects of Depakote and Depakene include:

• nausea
• headache
• sleepiness
• vomiting
• weakness
• tremor
• dizziness
• stomach pain
• blurry vision
• double vision
• diarrhea
• increased appetite
• weight gain
• hair loss
• loss of appetite
• problems with walking or coordination

These are not all of the possible side effects of Depakote or Depakene. For more information, ask your healthcare provider or pharmacist.

Tell your healthcare provider if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

How should I store Depakote or Depakene?

• Store Depakote Extended Release Tablets between 59°F to 86°F (15°C to 30°C).
• Store Depakote Delayed Release Tablets below 86°F (30°C).
• Store Depakote Sprinkle Capsules below 77°F (25°C).
• Store Depakene Capsules at 59°F to 77°F (15°C to 25°C).
• Store Depakene Oral Solution below 86°F (30°C).

Keep Depakote or Depakene and all medicines out of the reach of children.

General information about the safe and effective use of Depakote or Depakene

Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Do not use Depakote or Depakene for a condition for which it was not prescribed. Do not give Depakote or Depakene to other people, even if they have the same symptoms that you have. It may harm them.

This Medication Guide summarizes the most important information about Depakote or Depakene. If you would like more information, talk with your healthcare provider. You can ask your pharmacist or healthcare provider for information about Depakote or Depakene that is written for health professionals.

For more information, go to www.rxabbvie.com or call 1-800-633-9110.

What are the ingredients in Depakote or Depakene?

Depakote:

Active ingredient: divalproex sodium

Inactive ingredients:

• Depakote Extended Release Tablets: FD&C Blue No. 1, hypromellose, lactose, microcrystalline cellulose, polyethylene glycol, potassium sorbate, propylene glycol, silicon dioxide, titanium dioxide, and triacetin. The 500 mg tablets also contain iron oxide and polydextrose.
• Depakote Tablets: cellulosic polymers, diacetylated monoglycerides, povidone, pregelatinized starch (contains corn starch), silica gel, talc, titanium dioxide, and vanillin.

Individual tablets also contain:

125 mg tablets: FD&C Blue No. 1 and FD&C Red No. 40,

250 mg tablets: FD&C Yellow No. 6 and iron oxide,

500 mg tablets: D&C Red No. 30, FD&C Blue No. 2, and iron oxide.

• Depakote Sprinkle Capsules: cellulosic polymers, D&C Red No. 28, FD&C Blue No. 1 gelatin, iron oxide, magnesium stearate, silica gel, titanium dioxide, and triethyl citrate.

Depakene:

Active ingredient: valproic acid

Inactive ingredients:

• Depakene Capsules: corn oil, FD&C Yellow No. 6, gelatin, glycerin, iron oxide, methylparaben, propylparaben, and titanium dioxide.
• Depakene Oral Solution: FD&C Red No. 40, glycerin, methylparaben, propylparaben, sorbitol, sucrose, water, and natural and artificial flavors.

Divalproex Sodium is part of the drug class:

• Fatty acid derivatives

Take divalproex exactly as prescribed by your doctor. Follow the directions on your prescription label carefully. The dosage will vary, depending on the indication and response.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your age

The recommended starting dose of divalproex for the treatment of mania in bipolar disorder is 750 mg daily. The dose is increased on the basis of response or desired levels in the blood. The maximum recommended dosage is 60 mg/kg/day.

The recommended starting of divalproex for the treatment of complex partial seizures is 10 to 15 mg/kg/day. The dose is increased at 1-week intervals by 5 to 10 mg/kg/day to achieve clinical response. The maximum recommended dosage is 60 mg/kg/day.

The recommended starting dose of divalproex for the treatment of absence seizures is 15 mg/kg/day. The dose is increased at 1-week intervals by 5 to 10 mg/kg/day until seizure control is achieved or side effects are not tolerable. The maximum recommended dosage is 60 mg/kg/day.

The recommended starting dose of divalproex for the prevention of migraine is 250 mg twice daily. The dose may be increased until migraine control is achieved. The maximum recommended dose is 1000 mg/day as needed.

Divalproex sodium may cause harm to an unborn baby, but having a seizure during pregnancy could harm both the mother and the baby. Tell your doctor right away if you become pregnant while taking divalproex sodium for seizures. Do not start or stop taking divalproex sodium during pregnancy without your doctor's advice.

Seek emergency medical attention if the person taking this medicine has nausea, vomiting, upper stomach pain, or loss of appetite, low fever, dark urine, clay-colored stools, or jaundice (yellowing of the skin or eyes). These symptoms may be early signs of liver damage or pancreatitis.

Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, depression, anxiety, or if you feel agitated, hostile, restless, hyperactive (mentally or physically), or have thoughts about suicide or hurting yourself.

• Mechanism of action not known.b

• Effects may be related, at least in part, to increased brain concentrations of the inhibitory neurotransmitter, GABA.b

• May inhibit neuronal activity by increasing potassium conductance.b

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For divalproex sodium, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to divalproex sodium or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of divalproex sodium in children. However, safety and efficacy have not been established for other indications in children, and to treat seizures in children younger than 10 years of age. Because of divalproex sodium's toxicity, use in children younger than 2 years of age requires extreme caution.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of divalproex sodium in the elderly. However, elderly patients are more likely to have unwanted effects (eg, tremors or unusual drowsiness), which may require an adjustment in the dose for patients receiving divalproex sodium.

Pregnancy

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking divalproex sodium, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using divalproex sodium with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Calcifediol
• Cisplatin
• Doripenem
• Ertapenem
• Estradiol
• Ethinyl Estradiol
• Imipenem
• Lamotrigine
• Meropenem
• Mestranol
• Orlistat
• Primidone
• Propofol
• Sodium Oxybate
• Vorinostat
• Warfarin

Using divalproex sodium with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acyclovir
• Aspirin
• Betamipron
• Carbamazepine
• Cholestyramine
• Clomipramine
• Erythromycin
• Ethosuximide
• Felbamate
• Fosphenytoin
• Ginkgo
• Lopinavir
• Lorazepam
• Mefloquine
• Nimodipine
• Nortriptyline
• Olanzapine
• Oxcarbazepine
• Panipenem
• Phenobarbital
• Phenytoin
• Rifampin
• Rifapentine
• Risperidone
• Ritonavir
• Rufinamide
• Topiramate
• Valacyclovir
• Zidovudine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Other Medical Problems

The presence of other medical problems may affect the use of divalproex sodium. Make sure you tell your doctor if you have any other medical problems, especially:

• Congenital metabolism disorders (born with a disease that affects metabolism) or
• Mental retardation with severe seizure disorders—Use with caution. May increase risk for more serious side effects.

• Depression or
• Liver disease, history of or
• Mental illness or
• Pancreatitis (inflammation of the pancreas) or
• Thrombocytopenia (low platelet count)—Use with caution. May make these conditions worse.

• Liver disease or
• Mitochondrial disorders, including Alpers-Huttenlocher syndrome (genetic disorder) or
• Urea cycle disorder (genetic disorder)—Should not be used in patients with these conditions.

• Pregnant women with migraine headaches—Should not be used to prevent migraine headaches in these patients.

Take divalproex sodium exactly as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. To keep blood levels constant, take divalproex sodium at the same time each day and do not miss any doses.

divalproex sodium comes with a Medication Guide and a patient information insert. Read and follow the instructions in the insert carefully. Ask your doctor if you have any questions.

You may take divalproex sodium with food to avoid stomach upset.

The sprinkle capsules may be opened and the contents may be sprinkled onto soft food such as applesauce or pudding. This mixture must be swallowed immediately without chewing and followed with a glass of water to ensure complete swallowing of the sprinkles.

Swallow the extended release tablet or tablet whole with a full glass of water. Do not split, crush, or chew it.

If you are taking the sprinkle capsules, part of the capsules may pass into your stool after your body has absorbed the medicine. This is normal and not something to worry about.

Dosing

The dose of divalproex sodium will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of divalproex sodium. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral dosage forms (delayed-release tablets or tablets):
  • For mania:
    • Adults—At first, 750 milligrams (mg) once a day, usually divided in smaller doses. Your doctor may increase your dose as needed. However, the dose is usually not more than 60 mg per kilogram (kg) of body weight per day.
    • Children—Use and dose must be determined by your doctor.
  • For migraine:
    • Adults—At first, 250 milligrams (mg) two times a day. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg per day.
    • Children—Use and dose must be determined by your doctor.
  • For seizures:
    • Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may increase your dose gradually every week by 5 to 10 mg per kg of body weight if needed. However, the dose is usually not more than 60 mg per kg of body weight per day. If the total dose a day is greater than 250 mg, it is usually divided into smaller doses and taken two or more times during the day.
    • Children younger than 10 years of age—Use and dose must be determined by your doctor.
• For oral dosage form (extended release tablets):
  • For mania:
    • Adults—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 25 milligrams (mg) per kilogram (kg) of body weight once a day. Your doctor may increase your dose if needed. However, the dose is usually not more than 60 mg per kg of body weight per day.
    • Children—Use and dose must be determined by your doctor.
  • For migraine:
    • Adults—At first, 500 milligrams (mg) once a day for 1 week. Your doctor may increase your dose as needed. However, the dose is usually not more than 1000 mg per day.
    • Children—Use and dose must be determined by your doctor.
  • For seizures:
    • Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight per day. Your doctor may increase your dose gradually every week by 5 to 10 mg per kg of body weight if needed. However, the dose is usually not more than 60 mg per kg of body weight per day.
    • Children younger than 10 years of age—Use and dose must be determined by your doctor.
• For oral dosage form (sprinkle capsules):
  • For seizures:
    • Adults and children 10 years of age or older—Dose is based on body weight and must be determined by your doctor. At first, the usual dose is 10 to 15 milligrams (mg) per kilogram (kg) of body weight a day. Your doctor may increase your dose gradually every week by 5 to 10 mg per kg of body weight if needed. However, the dose is usually not more than 60 mg per kg of body weight per day. If the total dose a day is greater than 250 mg, it is usually divided into smaller doses and taken two or more times during the day.
    • Children younger than 10 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of divalproex sodium, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.