Desyrel Dividose Oral

Immediate-release tablets:
150 mg orally per day in divided doses; this may be increased by 50 mg orally per day every 3 to 4 days
Maximum dose: 400 mg orally per day in divided doses (outpatients); 600 mg orally per day in divided doses (inpatients)

Extended-release tablets:
150 mg orally once a day; this may be increased by 75 mg orally per day every 3 days (i.e., start 225 mg orally on Day 4 of therapy)
Maximum dose: 375 mg orally per day

Comments:
-Patients should be monitored for withdrawal symptoms when discontinuing therapy.
-After an adequate response has been reached, dosage may be gradually reduced depending on therapeutic response.
-If drowsiness develops, a major portion of the daily dose may be administered at bedtime or a reduction of dosage may be necessary.
-Immediate release tablets should be taken shortly after a meal or light snack.
-Extended release tablets should be taken orally at the same time every day, in the late evening preferably at bedtime, on an empty stomach.

Use: Treatment of major depressive disorder (MDD) in adults

Hepatic impairment: Use with caution