Dexchlorpheniramine and pseudoephedrine

Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using dexchlorpheniramine and pseudoephedrine and call your doctor at once if you have:

• chest pain, rapid pulse, fast or uneven heart rate;

• confusion, hallucinations, severe nervousness;

• tremor, seizure (convulsions);

• little or no urinating;

• easy bruising or bleeding, unusual weakness; or

• dangerously high blood pressure (severe headache, buzzing in your ears, anxiety, shortness of breath).

Common side effects may include:

• dizziness, drowsiness, blurred vision;

• dry nose or mouth;

• nausea, stomach pain, constipation, loss of appetite;

• problems with memory or concentration; or

• feeling restless or excited (especially in children).

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1 800 FDA 1088.

Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking dexchlorpheniramine and pseudoephedrine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

• Alkylamine Derivative
• Alpha/Beta Agonist
• Decongestant
• Histamine H1 Antagonist
• Histamine H1 Antagonist, First Generation

Dexchlorpheniramine: Competes with histamine for H1-receptor sites on effector cells in the gastrointestinal tract, blood vessels, and respiratory tract. Dexchlorpheniramine is the predominant active isomer of chlorpheniramine and is approximately twice as active as the racemic compound (Moreno 2010).

Pseudoephedrine: Directly stimulates alpha-adrenergic receptors of respiratory mucosa causing vasoconstriction; directly stimulates beta-adrenergic receptors causing bronchial relaxation, increased heart rate and contractility.

OTC labeling: When used for self-medication, do not use with or within 2 weeks of discontinuing an MAO inhibitor or if you have emphysema or chronic bronchitis.

Refer to adult dosing.

There are no dosage adjustments provided in the manufacturer's labeling; use with caution.

There are no adverse reactions listed in the manufacturer’s labeling. See individual agents.

Refer to individual agents.