Desoximetasone

Dosage Forms & Strengths

topical cream

• 0.05%
• 0.25%

topical gel

• 0.05%

topical ointment

• 0.25%
• 0.05%

Corticosteroid-Responsive Dermatoses

Apply thin film topically to affected area(s) q12hr; discontinue therapy if control achieved and reassess diagnosis if no improvement within 4 weeks

Dosage Forms & Strengths

topical cream

• 0.05%
• 0.25%

topical gel

• 0.05%

topical ointment

• 0.25%

Corticosteroid-Responsive Dermatoses

High-potency topical steroid

Apply sparingly to affected area(s) q12 hr and limit to minimum amount necessary for therapeutic efficacy; avoid face; ; discontinue therapy if control achieved and reassess diagnosis if no improvement within 4 weeks

Desoximetasone Ointment, USP 0.25% is supplied in:

15 gram tubes     NDC 0713-0657-15
60 gram tubes      NDC 0713-0657-60

Store at 20°-25°C (68°-77°F) [See USP Controlled Room Temperature].

Manufactured by: G&W Laboratories, Inc. 111 Coolidge Street, South Plainfield, NJ 07080. Revised: Mar 2016

Desoximetasone is used in the treatment of:

• Facial Dermatoses
• Foot Dermatoses
• Hand Dermatoses
• Inflammation
• Leg Dermatoses
• Scalp Dermatoses

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

You should not use this medication if you are allergic to desoximetasone.

To make sure you can safely use desoximetasone topical, tell your doctor if you are allergic to any drugs, or if you have any type of skin infection.

Also tell your doctor if you have diabetes. Topical steroid medicines absorbed through the skin may increase the glucose (sugar) levels in your blood or urine.

FDA pregnancy category C. It is not known whether desoximetasone topical will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

It is not known whether desoximetasone topical passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Do not use this medication on a child without a doctor's advice. Children are more likely to absorb large amounts of a topical steroid through the skin. Steroid absorption in children may cause unwanted side effects, or a delay in growth with long-term use. Talk with your doctor if you think your child is not growing at a normal rate while using this medication over a long treatment period.

Corticosteroid-responsive Dermatoses

Relief of inflammatory and pruritic manifestations of corticosteroid-responsive dermatoses.a c d e

Generally most effective in acute or chronic dermatoses (e.g., seborrheic or atopic dermatitis, localized neurodermatitis, anogenital pruritus, psoriasis, late phase of allergic contact dermatitis, inflammatory phase of xerosis).b

Topical therapy generally preferred over systemic therapy; fewer associated adverse systemic effects.b

Topical therapy generally only controls manifestations of dermatoses; eliminate cause if possible.b

Topical efficacy may be increased by using a higher concentration or occlusive dressing therapy. (See Administration with Occlusive Dressing under Dosage and Administration.)b

Response may vary from one topical corticosteroid preparation to another.b

Anti-inflammatory activity may vary considerably depending on the vehicle, drug concentration, site of application, disease, and individual patient.b

Desoximetasone cream, ointment, and gel are considered to have high-range potency.b

Specific Drugs and Laboratory Tests

Storage

Topical

Cream, ointment, and gel:15–30°C; well-closed container.a c

• Precise mechanism of action for topical anti-inflammatory activity is unknown; therapeutic benefit in the management of corticosteroid-responsive dermatoses mediated primarily through anti-inflammatory, antipruritic, and vasoconstrictive actions.c d e

• Decreases inflammation by stabilizing leukocyte lysosomal membranes, preventing release of destructive acid hydrolases from leukocytes; inhibiting macrophage accumulation in inflamed areas; reducing leukocyte adhesion to capillary endothelium; reducing capillary wall permeability and edema formation; decreasing complement components; antagonizing histamine activity and release of kinin from substrates; reducing fibroblast proliferation, collagen deposition, and subsequent scar tissue formation; and possibly by other mechanisms as yet unknown.b

Cream, gel, ointment: Relief of inflammation and pruritic symptoms of corticosteroid-responsive dermatoses

Spray: Plaque psoriasis treatment

Cream, gel, ointment: Hypersensitivity to desoximetasone or any component of the formulation

Spray: There are no contraindications listed in the manufacturer’s labeling.

Consult your pharmacist.