Darunavir, Cobicistat, Emtricitabine, And Tenofovir Alafenamide (Oral Route)

Darunavir, cobicistat, emtricitabine, and tenofovir alafenamide combination is used to treat human immunodeficiency virus (HIV) infection. HIV is the virus that causes acquired immune deficiency syndrome (AIDS). This medicine is usually given to patients who have yet not received any medicine for HIV infection.

Darunavir, cobicistat, emtricitabine, and tenofovir alafenamide combination will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay problems that are usually related to AIDS or HIV disease from occurring. This medicine will not keep you from spreading HIV to other people. People who receive this medicine may continue to have other problems usually related to AIDS or HIV disease.

This medicine is available only with your doctor's prescription.

This product is available in the following dosage forms:

• Tablet

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Appropriate studies have not been performed on the relationship of age to the effects of darunavir, cobicistat, emtricitabine, and tenofovir alafenamide combination in children. Safety and efficacy have not been established.

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

• Alfuzosin
• Astemizole
• Carbamazepine
• Cisapride
• Colchicine
• Conivaptan
• Crizotinib
• Dihydroergotamine
• Domperidone
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Dronedarone
• Eletriptan
• Eliglustat
• Eplerenone
• Ergonovine
• Ergotamine
• Fosphenytoin
• Grazoprevir
• Isavuconazonium Sulfate
• Ivabradine
• Lomitapide
• Lovastatin
• Lurasidone
• Maraviroc
• Methylergonovine
• Midazolam
• Naloxegol
• Pazopanib
• Phenobarbital
• Phenytoin
• Pimozide
• Primidone
• Ranolazine
• Rifampin
• Riociguat
• Romidepsin
• Sildenafil
• Silodosin
• Simvastatin
• St John's Wort
• Terfenadine
• Tolvaptan
• Triazolam
• Venetoclax

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Acalabrutinib
• Ado-Trastuzumab Emtansine
• Afatinib
• Alfentanil
• Alprazolam
• Amineptine
• Amiodarone
• Amitriptyline
• Amitriptylinoxide
• Amobarbital
• Amoxapine
• Amprenavir
• Apalutamide
• Apixaban
• Aprepitant
• Aprobarbital
• Aripiprazole
• Atazanavir
• Atomoxetine
• Atorvastatin
• Avanafil
• Bedaquiline
• Benzhydrocodone
• Betrixaban
• Boceprevir
• Bosentan
• Bosutinib
• Brigatinib
• Bromocriptine
• Budesonide
• Buprenorphine
• Buspirone
• Butabarbital
• Butalbital
• Cabazitaxel
• Cabozantinib
• Calcifediol
• Cariprazine
• Ceritinib
• Cilostazol
• Clarithromycin
• Clomipramine
• Cobimetinib
• Codeine
• Conivaptan
• Copanlisib
• Cyclophosphamide
• Cyclosporine
• Dabigatran Etexilate
• Dabrafenib
• Daclatasvir
• Dasabuvir
• Dasatinib
• Deflazacort
• Delamanid
• Delavirdine
• Desipramine
• Desogestrel
• Dexamethasone
• Dextromethorphan
• Diazepam
• Dibenzepin
• Didanosine
• Dienogest
• Digoxin
• Dihydrocodeine
• Disopyramide
• Docetaxel
• Domperidone
• Donepezil
• Doxepin
• Doxorubicin
• Doxorubicin Hydrochloride Liposome
• Drospirenone
• Duloxetine
• Duvelisib
• Efavirenz
• Elagolix
• Elvitegravir
• Encorafenib
• Erlotinib
• Erythromycin
• Eslicarbazepine Acetate
• Estazolam
• Estradiol Cypionate
• Estradiol Valerate
• Eszopiclone
• Ethinyl Estradiol
• Ethynodiol Diacetate
• Etonogestrel
• Etravirine
• Everolimus
• Fentanyl
• Flecainide
• Fluoxetine
• Fluticasone
• Fluvastatin
• Fosamprenavir
• Fosaprepitant
• Fosnetupitant
• Gestodene
• Glecaprevir
• Haloperidol
• Horsetail
• Hydrocodone
• Hydrocortisone
• Ibrutinib
• Idelalisib
• Ifosfamide
• Iloperidone
• Imipramine
• Irinotecan
• Irinotecan Liposome
• Itraconazole
• Ivacaftor
• Ivosidenib
• Ketoconazole
• Lapatinib
• Levomilnacipran
• Levonorgestrel
• Lidocaine
• Lofepramine
• Lopinavir
• Lumacaftor
• Macitentan
• Manidipine
• Medroxyprogesterone Acetate
• Melitracen
• Meperidine
• Mephobarbital
• Mestranol
• Methadone
• Methohexital
• Mexiletine
• Midostaurin
• Mifepristone
• Modafinil
• Morphine
• Morphine Sulfate Liposome
• Nafcillin
• Naloxegol
• Nelfinavir
• Neratinib
• Netupitant
• Nevirapine
• Nifedipine
• Nilotinib
• Nimodipine
• Nisoldipine
• Norelgestromin
• Norethindrone
• Norgestimate
• Norgestrel
• Nortriptyline
• Olaparib
• Ombitasvir
• Ondansetron
• Opipramol
• Orlistat
• Oxcarbazepine
• Oxycodone
• Palbociclib
• Panobinostat
• Paritaprevir
• Pentazocine
• Pentobarbital
• Perphenazine
• Pibrentasvir
• Pimavanserin
• Piperaquine
• Pitavastatin
• Pixantrone
• Ponatinib
• Pravastatin
• Prednisolone
• Prednisone
• Primidone
• Propafenone
• Propranolol
• Protriptyline
• Quetiapine
• Quinidine
• Reboxetine
• Regorafenib
• Retapamulin
• Ribociclib
• Rifabutin
• Rifapentine
• Ritonavir
• Rivaroxaban
• Rosuvastatin
• Ruxolitinib
• Salmeterol
• Saquinavir
• Secobarbital
• Simeprevir
• Sirolimus
• Sonidegib
• Sufentanil
• Sunitinib
• Suvorexant
• Tacrolimus
• Tadalafil
• Tamoxifen
• Tamsulosin
• Telaprevir
• Telithromycin
• Temsirolimus
• Tezacaftor
• Thiopental
• Thiotepa
• Tianeptine
• Ticagrelor
• Tipranavir
• Tolvaptan
• Topotecan
• Toremifene
• Trabectedin
• Tramadol
• Trazodone
• Trimipramine
• Valbenazine
• Vardenafil
• Vemurafenib
• Venlafaxine
• Vilanterol
• Vilazodone
• Vinblastine
• Vincristine
• Vincristine Sulfate Liposome
• Vinflunine
• Vorapaxar
• Voriconazole
• Warfarin
• Zolpidem

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

• Aripiprazole Lauroxil
• Atazanavir
• Atorvastatin
• Clarithromycin
• Cobicistat
• Darunavir
• Digoxin
• Indinavir
• Ketoconazole
• Nelfinavir
• Tenofovir Disoproxil Fumarate

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.