Curretab

The following side effects have been reported with the use of medroxyprogesterone alone:

• Breast tenderness
• Breast milk secretion
• Breakthrough bleeding
• Spotting (minor vaginal bleeding)
• Irregular periods
• Amenorrhea (absence of menstrual periods)
• Vaginal secretions
• Headaches
• Nervousness
• Dizziness
• Depression
• Insomnia, sleepiness, fatigue
• Premenstrual syndrome-like symptoms
• Thrombophlebitis (inflamed veins)
• Blood clot
• Itching, hives, skin rash
• Acne
• Hair loss, hair growth
• Abdominal discomfort
• Nausea
• Bloating
• Fever
• Increase in weight
• Swelling
• Changes in vision and sensitivity to contact lenses

The following side effects have been reported with the use of medroxyprogesterone with an estrogen.

Side effects are grouped by how serious they are and how often they happen when you are treated:

Serious but less common side effects of estrogen include:

• Breast cancer
• Cancer of the uterus
• Stroke
• Heart attack
• Blood clots
• Dementia
• Gallbladder disease
• Ovarian cancer
• High blood pressure
• Liver problems
• High blood sugar
• Enlargement of benign tumors of the uterus ("fibroids")

Some of the warning signs of these serious side effects include:

• Breast lumps
• Unusual vaginal bleeding
• Dizziness and faintness
• Changes in speech
• Severe headaches
• Chest pain
• Shortness of breath
• Pains in your legs
• Changes in vision
• Vomiting
• Yellowing of the skin, eyes or nail beds

Call your healthcare provider right away if you get any of these warning signs, or any other unusual symptom that concerns you.

Less serious but common side effects include:

• Headache
• Breast pain
• Irregular vaginal bleeding or spotting
• Stomach/abdominal cramps, bloating
• Nausea and vomiting
• Hair loss
• Fluid retention
• Vaginal yeast infection

These are not all the possible side effects of medroxyprogesterone with or without estrogen. For more information, ask your healthcare provider or pharmacist.

Tell your healthcare provider about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take thyroid medications including:

• liothyronine (Cytomel)
• liotrix (Thyrolar)
• levothyroxine (Levothroid, Levoxyl, Synthroid, Tirosint, Unithroid)
• thyroid (Armor Thyroid, Nature-Thyroid, Westhroid)

This is not a complete list of medroxyprogesterone drug interactions. Ask your doctor or pharmacist for more information.

Studies have shown that using combination hormone therapy, or combination HT (estrogen and progesterone) increases the risk for heart attacks, stroke, breast cancer, dementia, and blood clots. Because of these risks, combination HT should only be used short-term at the lowest possible dose.

Medroxyprogesterone injection can cause bone loss, which may increase your risk for osteoporosis (weak and thinning bones) and fractures. The medication should not be used for longer than two years unless absolutely necessary as long-term therapy will increase risk of bone loss.

Vaginal bleeding after menopause may be a warning sign of cancer of the uterus (womb). Your health care provider should check any unusual vaginal bleeding to find out the cause.

Do not use estrogens with or without progestins to prevent heart disease, heart attacks, or strokes. Using estrogens with or without progestins may increase your chance of getting heart attacks, strokes, breast cancer, and blood clots.

Using estrogens with or without progestins may increase your risk of dementia, based on a study of women age 65 years or older.

You and your healthcare provider should talk regularly about whether you still need treatment with medroxyprogesterone.

Do not start taking medroxyprogesterone if you:

• have undiagnosed vaginal bleeding.
• currently have or have had certain cancers.
  • Estrogen plus progestin may increase your chance of getting certain cancers, including cancer of the breast. If you have or have had cancer, talk with your healthcare provider about whether you should use medroxyprogesterone.

• had a stroke or heart attack in the past year.
• currently have or have had blood clots.
• currently have or have had liver problems.
• think you may be pregnant.
  • Tell your healthcare provider if you think that you may be pregnant or having a miscarriage. There may be an increased risk of minor birth defects in children whose mothers take this drug during the first 4 months of pregnancy. If you take medroxyprogesterone and later find out you were pregnant when you took it, be sure to discuss this with your doctor as soon as possible.
  • medroxyprogesterone should not be used as a test for pregnancy.

• are allergic to any of the ingredients in medroxyprogesterone.

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of medroxyprogesterone, there are no specific foods that you must exclude from your diet when receiving this medication.

Tell your healthcare provider if you are breastfeeding. Medroxyprogesterone has been detected in human breast milk and should not be used while breastfeeding.

Store medroxyprogesterone at room temperature 20° to 25°C (68° to 77°F).

Keep medroxyprogesterone and all medicines out of the reach of children.