Cefazolin injection

You should not use this medicine if you have ever had a severe allergic reaction to cefazolin or any other cephalosporin antibiotic, such as:

• cefaclor (Raniclor);

• cefadroxil (Duricef);

• cefdinir (Omnicef);

• cefazolin (Ancef);

• cefditoren (Spectracef);

• cefpodoxime (Vantin);

• cefprozil (Cefzil);

• ceftibuten (Cedax);

• cefuroxime (Ceftin);

• cephalexin (Keflex); or

• cephradine (Velosef).

To make sure cefazolin is safe for you, tell your doctor if you have:

• kidney disease;

• liver disease;

• a stomach or intestinal disorder such as colitis;

• if you are malnourished; or

• if you are allergic to any type of penicillin.

Cefazolin is not expected to harm an unborn baby. Tell your doctor if you are pregnant.

Cefazolin can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Antibiotic medicines can cause diarrhea, which may be a sign of a new infection. If you have diarrhea that is watery or bloody, stop using cefazolin and call your doctor. Do not use anti-diarrhea medicine unless your doctor tells you to.

Other drugs may interact with cefazolin, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

In the U.S.

• Ancef

Available Dosage Forms:

• Powder for Solution
• Solution

Therapeutic Class: Antibiotic

Pharmacologic Class: 1st Generation Cephalosporin

Cefazolin is used to treat bacterial infections in many different parts of the body. cefazolin is also given before certain types of surgery to prevent infections.

Cefazolin belongs to the class of medicines known as cephalosporin antibiotics. It works by killing bacteria or preventing their growth. However, cefazolin will not work for colds, flu, or other virus infections.

cefazolin is available only with your doctor's prescription.

Cefazolin for injection is contraindicated in patients with known allergy to the cephalosporin group of antibiotics.

Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent infection. This medication is known as a cephalosporin antibiotic. It works by stopping the growth of bacteria.

How to use Cefazolin SODIUM Vial

Depending on your specific product, this medication is given by injection into a vein or into a muscle. Use this product exactly as directed by your doctor. The dosage is based on your medical condition and response to treatment. For children, the dosage is also based on their weight.

If you are giving this medication to yourself at home, learn all preparation and usage instructions from your health care professional. Before using, check this product visually for particles or discoloration. If either is present, do not use the liquid. Learn how to store and discard medical supplies safely.

For the best effect, use this antibiotic at evenly spaced times. To help you remember, use this medication at the same time(s) every day.

Continue to use this medication until the full prescribed treatment period is finished, even if symptoms disappear after a few days. Stopping the medication too early may result in a return of the infection.

Tell your doctor if your condition persists or worsens.

Before using cefazolin, tell your doctor or pharmacist if you are allergic to it; or to other cephalosporins; or to penicillins; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: kidney disease, liver disease, stomach/intestinal diseases (e.g., colitis).

Cefazolin may cause live bacterial vaccines (such as typhoid vaccine) to not work as well. Do not have any immunizations/vaccinations while using this medication unless your doctor tells you to.

Kidney function declines as you grow older. This medication is removed by the kidneys. Therefore, elderly people may be at greater risk for side effects while using this drug.

Tell your doctor if you are pregnant before using this medication.

This medication passes into breast milk and may have undesirable effects on a nursing infant. Consult your doctor before breast-feeding.

Mild infections due to susceptible gram-positive cocci: 250 to 500 mg IV or IM every 8 hours
Moderate to severe infections: 500 mg to 1 g IV or IM every 6 to 8 hours
Severe, life-threatening infections (e.g., endocarditis, septicemia): 1 to 1.5 g IV every 6 hours

Comments:
-In rare cases, doses up to 12 g/day have been used for severe, life-threatening infections.

Uses: For the treatment of the following infections due to susceptible bacteria:
-Biliary tract infections due to Escherichia coli, various strains of streptococci, Proteus mirabilis, Klebsiella species, and Staphylococcus aureus
-Bone and joint infections due to S aureus
-Genital infections (i.e., prostatitis, epididymitis) due to E coli, P mirabilis, Klebsiella species, and some strains of enterococci
-Respiratory tract infections due to Streptococcus pneumoniae, S aureus, S pyogenes/group A beta-hemolytic streptococci, Klebsiella species, and Haemophilus influenzae
-Skin and skin structure infections due to S aureus, S pyogenes/group A beta-hemolytic streptococci, S agalactiae, and other strains of streptococci

1 g IV or IM every 12 hours

Use: For the treatment of acute, uncomplicated urinary tract infections due to E coli, P mirabilis, Klebsiella species, and some strains of Enterobacter and enterococci

1 month or older:
-Mild to moderate infections: 25 to 50 mg/kg/day IV or IM in 3 or 4 equally divided doses
-Severe infections: 100 mg/kg/day IV or IM in 3 or 4 equally divided doses

Uses: For the treatment of the following infections due to susceptible bacteria:
-Biliary tract infections due to E coli, various strains of streptococci, P mirabilis, Klebsiella species, and S aureus
-Bone and joint infections due to S aureus
-Genital infections (i.e., prostatitis, epididymitis) due to E coli, P mirabilis, Klebsiella species, and some strains of enterococci
-Respiratory tract infections due to S pneumoniae, S aureus, S pyogenes/group A beta-hemolytic streptococci, Klebsiella species, and H influenzae
-Skin and skin structure infections due to S aureus, S pyogenes/group A beta-hemolytic streptococci, S agalactiae, and other strains of streptococci
-Urinary tract infections due to E coli, P mirabilis, Klebsiella species, and some strains of Enterobacter and enterococci

American Academy of Pediatrics (AAP) Recommendations:
7 days or younger: 25 mg/kg IV or IM every 12 hours

8 to 28 days:
Up to 2 kg: 25 mg/kg IV or IM every 12 hours
Greater than 2 kg: 25 mg/kg IV or IM every 8 hours

1 month or older:
Mild to moderate infections: 25 to 50 mg/kg/day IV or IM in 3 divided doses
Maximum dose: 3 g/day

Severe infections: 100 to 150 mg/kg IV or IM in 3 divided doses
Maximum dose: 6 g/day

1 month or older:
-Mild to moderate infections: 25 to 50 mg/kg/day IV or IM in 3 or 4 equally divided doses
-Severe infections: 100 mg/kg/day IV or IM in 3 or 4 equally divided doses

Uses: For the treatment of the following infections due to susceptible bacteria:
-Biliary tract infections due to E coli, various strains of streptococci, P mirabilis, Klebsiella species, and S aureus
-Bone and joint infections due to S aureus
-Genital infections (i.e., prostatitis, epididymitis) due to E coli, P mirabilis, Klebsiella species, and some strains of enterococci
-Respiratory tract infections due to S pneumoniae, S aureus, S pyogenes/group A beta-hemolytic streptococci, Klebsiella species, and H influenzae
-Skin and skin structure infections due to S aureus, S pyogenes/group A beta-hemolytic streptococci, S agalactiae, and other strains of streptococci
-Urinary tract infections due to E coli, P mirabilis, Klebsiella species, and some strains of Enterobacter and enterococci

American Academy of Pediatrics (AAP) Recommendations:
7 days or younger: 25 mg/kg IV or IM every 12 hours

8 to 28 days:
Up to 2 kg: 25 mg/kg IV or IM every 12 hours
Greater than 2 kg: 25 mg/kg IV or IM every 8 hours

1 month or older:
Mild to moderate infections: 25 to 50 mg/kg/day IV or IM in 3 divided doses
Maximum dose: 3 g/day

Severe infections: 100 to 150 mg/kg IV or IM in 3 divided doses
Maximum dose: 6 g/day