Brompheniramine

Name: Brompheniramine

Brompheniramine Brand Names

Brompheniramine may be found in some form under the following brand names:

  • AccuHist DM Pediatric

  • AccuHist DM Pediatric Drops

  • AccuHist PDX

  • AccuHist Pediatric

  • Acutuss DM Pediatric

  • Ala-Hist DM

  • Alacol

  • Alacol DM

  • Alenaze-D

  • Alka-Seltzer Plus Night Time

  • Allanhist

  • Allanhist PDX

  • Allent

  • Altatapp

  • Annaplex DMX

  • Balacall DM

  • Betatan

  • Bidhist

  • Bidhist-D

  • Brofed

  • Brom Tann

  • Brom Tann PE

  • Bromaline

  • Bromaline DM

  • Bromaline Plus

  • Bromanate

  • Bromanate DC

  • Bromanate DM

  • Bromanate DX Cough

  • Bromatol

  • Bromax

  • Bromaxefed DM RF Syrup

  • Bromaxefed RF

  • Bromdex D

  • Bromfed

  • Bromfed DM

  • Bromhist NR

  • Bromhist PDX

  • Bromhist PDX Syrup

  • Bromhist Pediatric Drops

  • Bromhist-DM

  • Bromhist-DM Drops

  • Bromophen TD

  • Bromph HD

  • Bromphenex DM

  • Bromplex DM

  • Bromplex HD

  • Bromtuss DM

  • BroveX

  • BroveX CB

  • BroveX CT

  • Brovex D

  • BroveX HC

  • Brovex PB

  • Brovex PBC

  • Brovex PBD

  • Brovex PD

  • BroveX PEB

  • BroveX PEB DM

  • BroveX PSB

  • BroveX PSB DM

  • Brovex PSE

  • Brovex PSE DM

  • Brovex SR

  • C Tan D

  • Canges-HC

  • Centussin

  • Codimal A

  • Comtrex Nighttime Acute Head Cold

  • Dallergy DM

  • Delhistine DM

  • Dicel CD

  • Dimetane

  • Dimetane DC

  • Dimetane Decongestant

  • Dimetane DX

  • Dimetane Extentab

  • Dimetapp Allergy Liquigel

  • Dimetapp Allergy Sinus

  • Dimetapp Children's Cold & Allergy

  • Dimetapp Children's Cold and Allergy Reformulated Jan 2011

  • Dimetapp Cold

  • Dimetapp Cold and Cough Liquigel

  • Dimetapp Cold and Fever

  • Dimetapp Cold and Flu

  • Dimetapp DM

  • Dimetapp DM Cold & Cough

  • Dimetapp Nighttime Flu

  • Dristan Cold Maximum Strength

  • Drocon-CS

  • DuraTan DM

  • Duravent DPB

  • Endafed

  • FluTuss HC

  • Histex SR

  • Histinex DM

  • J-Cof DHC

  • Liquiphed DM

  • Lodrane

  • Lodrane D

  • M-end

  • M-End PE

  • M-End WC

  • Mar-cof BP

  • Myphetane DC

  • Myphetane DX

  • Myphetapp

  • Nalex AC

  • Nasahist B

  • Neo DM

  • Pluratuss

  • Poly Histine DM

  • Poly-Histine CS

  • Poly-Tussin AC

  • Poly-Tussin DHC

  • Presgen

  • ProHist DM

  • Pulmari

  • Respa-BR

  • Respahist

  • Respahist II

  • Resperal-DM Drops

  • Rhinabid

  • Rhinabid PD

  • Robitussin Allergy & Cough

  • Rompe Pecho-SF

  • Rondec

  • Rx-Act Children's Cold and Allergy

  • Rynex-DM

  • Seradex

  • Seradex-LA

  • Siltane

  • Sinuhist

  • SymTan A

  • Tanabid SR

  • TL-Hist CD

  • TL-Hist DM

  • Touro A&H

  • Touro Allergy

  • Trexbrom

  • Trexbrom Reformulated Jun 2011

  • Tusdec-DM

  • Tusnel

  • Tussi Pres B Reformulated Aug 2011

  • Ultrabrom

  • Ultrabrom PD

  • Uni Hist PDX

  • Uni-Hist DM Pediatric Drops

  • Uni-Hist PDX Drops

  • V-Cof

  • Vazobid-PD

  • Vazol

  • VaZol D

  • Vazotab

  • Vazotan

  • Vazotuss HC

  • Wal-Tap Children's Cold & Allergy

  • Wal-Tap DM

  • Zotex PE

Brompheniramine Drug Class

Brompheniramine is part of the drug class:

  • Substituted alkylamines

How should I take brompheniramine?

Use exactly as directed on the label, or as prescribed by your doctor. Do not use in larger or smaller amounts or for longer than recommended. This medicine is usually taken only for a short time until your symptoms clear up.

Do not take for longer than 7 days in a row. Talk with your doctor if your symptoms do not improve after 7 days of treatment, or if you have a fever with a headache or skin rash.

Do not crush, chew, or break an extended-release tablet. Swallow it whole. Breaking the pill may cause too much of the drug to be released at one time.

Measure liquid medicine with a special dose-measuring spoon or medicine cup, not with a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.

Do not give this medication to a child younger than 4 years old. Always ask a doctor before giving a cough or cold medicine to a child. Death can occur from the misuse of cough and cold medicines in very young children.

If you need surgery or medical tests, tell the surgeon or doctor ahead of time if you have taken this medicine within the past few days.

Store at room temperature away from moisture and heat. Do not allow the liquid form of this medicine to freeze.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe forms of some of the side effects listed in this medication guide.

Brompheniramine dosing information

Usual Adult Dose for Cold Symptoms:

Immediate Release: 4 mg to 8 mg orally every 6 hours as needed. The duration of action varies from patient to patient. Many patients will require dosing only twice daily.

Extended Release: 6 mg to 12 mg extended release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.

Maximum oral dose 24 mg/day.

Usual Adult Dose for Allergic Rhinitis:

Immediate Release: 4 mg to 8 mg orally every 6 hours as needed. The duration of action varies from patient to patient. Many patients will require dosing only twice daily.

Extended Release: 6 mg to 12 mg extended release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.

Maximum oral dose 24 mg/day.

Usual Adult Dose for Urticaria:

Immediate Release: 4 mg to 8 mg orally every 6 hours as needed. The duration of action varies from patient to patient. Many patients will require dosing only twice daily.

Extended Release: 6 mg to 12 mg extended release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.

Maximum oral dose 24 mg/day.

Usual Adult Dose for Allergic Reaction:

Immediate Release: 4 mg to 8 mg orally every 6 hours as needed. The duration of action varies from patient to patient. Many patients will require dosing only twice daily.

Extended Release: 6 mg to mg 12 mg extended release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.

Maximum oral dose 24 mg/day.

IV, IM, subcutaneous: 5 mg to 20 mg every 6 to 12 hours. Duration of action is 3 to 12 hours.
Maximum parenteral dose 40 mg/day.

Usual Pediatric Dose for Allergic Rhinitis:

< 6 years:
Immediate Release:
0.125 mg/kg/dose orally every 6 hours. Maximum dose: 6 mg to 8 mg/day.

2 to 6 years:
Extended Release suspension:
2 mg orally twice daily, not to exceed 2 doses in 24 hours.

6 to 12 years:
Immediate Release:
2 mg to 4 mg orally every 6 to 8 hours. Maximum dose 12 to 16 mg/day.
Extended Release suspension:
4 mg orally twice daily, not to exceed 2 doses in 24 hours.

> 12 years:
Immediate Release:
4 mg to 8 mg orally every 6 hours as needed. The duration of action varies from patient to patient. Many patients will require dosing only twice daily.
Extended Release:
6 mg to 12 mg sustained release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.

Maximum oral dose 24 mg/day.

Usual Pediatric Dose for Cold Symptoms:

< 6 years:
Immediate Release:
0.125 mg/kg/dose orally every 6 hours. Maximum dose: 6 mg to 8 mg/day.

2 to 6 years:
Extended Release suspension:
2 mg orally twice daily, not to exceed 2 doses in 24 hours.

6 to 12 years:
Immediate Release:
2 mg to 4 mg orally every 6 to 8 hours. Maximum dose 12 to 16 mg/day.
Extended Release suspension:
4 mg orally twice daily, not to exceed 2 doses in 24 hours.

> 12 years:
Immediate Release:
4 mg to 8 mg orally every 6 hours as needed. The duration of action varies from patient to patient. Many patients will require dosing only twice daily.
Extended Release:
6 mg to 12 mg sustained release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.

Maximum oral dose 24 mg/day.

Usual Pediatric Dose for Urticaria:

< 6 years:
Immediate Release:
0.125 mg/kg/dose orally every 6 hours. Maximum dose: 6 mg to 8 mg/day.

2 to 6 years:
Extended Release suspension:
2 mg orally twice daily, not to exceed 2 doses in 24 hours.

6 to 12 years:
Immediate Release:
2 mg to 4 mg orally every 6 to 8 hours. Maximum dose 12 to 16 mg/day.
Extended Release suspension:
4 mg orally twice daily, not to exceed 2 doses in 24 hours.

> 12 years:
Immediate Release:
4 mg to 8 mg orally every 6 hours as needed. The duration of action varies from patient to patient. Many patients will require dosing only twice daily.
Extended Release:
6 mg to 12 mg sustained release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.

Maximum oral dose 24 mg/day.

Usual Pediatric Dose for Allergic Reaction:

< 6 years:
Immediate Release:
0.125 mg/kg/dose orally every 6 hours. Maximum dose: 6 mg to 8 mg/day.

2 to 6 yrs:
Extended Release Suspension:
2.5 mg extended release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.

6 to 12 years:
Immediate Release:
2 mg to 4 mg orally every 6 to 8 hours. Maximum dose 12 to 16 mg/day.
Extended Release Suspension:
5 mg extended release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.


> 12 years:
Immediate Release:
4 mg orally every 6 hours as needed. The duration of action varies from patient to patient. Many patients will require dosing only twice daily.
Extended Release:
6 mg to 12 mg extended release orally twice daily as needed. The duration of action varies from patient to patient. Many patients will require dosing only once a day, preferably at bedtime to avoid drowsiness.

Maximum oral dose 24 mg/day.

IM, IV, subcutaneous :
< 12 years:
0.5 mg/kg/day divided every 6 to 8 hours.

> 12 years:
5 mg to 20 mg every 6 to 12 hours. Duration of action is 3 to 12 hours.
Maximum parenteral dose 40 mg/day.

Pronunciation

(brome fen IR a meen)

Pharmacology

Competes with histamine for H1-receptor sites on effector cells

Distribution

Vd: Children: ~20 L/kg (Simons, 1999); Adults: ~12 L/kg (Simons, 1982)

Metabolism

Hepatic (Simons, 2004)

Excretion

Urine (Bruce, 1968)

Time to Peak

Serum: Children: 3-3.5 hours (Simons, 1999); Adults: 2-4 hours (Simons, 1982)

Half-Life Elimination

Children: ~12 hours (Simons, 1999); Adults: ~25 hours (Simons, 1982)

Protein Binding

39% to 49% (Martínez-Gómez, 2007)

Storage

Store between 15°C to 30°C (59˚F to 86°F). Protect from light.

For the Consumer

Applies to brompheniramine: oral liquid, oral tablet chewable, oral tablet extended release 12 hour

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Chest pain or pressure or a fast heartbeat.
  • A heartbeat that does not feel normal.
  • Shortness of breath.
  • Change in balance.
  • Change in eyesight.
  • Mood changes.
  • Hallucinations (seeing or hearing things that are not there).
  • Very bad sore throat.
  • Fever or chills.
  • Trouble passing urine.
  • Any unexplained bruising or bleeding.
  • Very bad dizziness or passing out.
  • Feeling very tired or weak.
  • Feeling confused.
  • Restlessness.
  • Shakiness.
  • Seizures.
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