Brinzolamide

Name: Brinzolamide

Dosing & Uses

Dosage Forms & Strengths

ophthalmic suspension

  • 1%

Ocular Hypertension or Open-Angle Glaucoma

1 gtt in affected eye q8hr

Administration

May be used concomitantly with other topical ophthalmic drug products to lower intraocular pressure; if more than one topical ophthalmic drug being used, administer at least ten min apart

Safety & efficacy not established

Side Effects of Brinzolamide

Common side effects include:

  • blurred vision
  • bitter, sour, or unusual taste after instilling the drops
  • dry eyes
  • feeling that something is in your eye
  • headache
  • runny nose

This is not a complete list of brinzolamide side effects. Ask your doctor or pharmacist for more information.

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Uses of Brinzolamide

  • It is used to treat glaucoma.
  • It is used to lower high eye pressure.

Dosage Forms

Excipient information presented when available (limited, particularly for generics); consult specific product labeling.

Suspension, Ophthalmic:

Azopt: 1% (10 mL, 15 mL) [contains benzalkonium chloride, edetate disodium]

Pharmacologic Category

  • Carbonic Anhydrase Inhibitor (Ophthalmic)
  • Ophthalmic Agent, Antiglaucoma

Dosing Hepatic Impairment

There are no dosage adjustments provided in the manufacturer’s labeling.

Administration

Ophthalmic: Shake well before use. Remove contact lenses prior to administration; wait 15 minutes before reinserting. If more than one topical ophthalmic drug is being used, administer drugs at least 10 minutes apart. Avoid allowing the tip of the dispensing container to contact the eye or surrounding structures.

Pregnancy Risk Factor C Pregnancy Considerations

Adverse events have been observed in animal reproduction studies.

In Summary

More frequently reported side effects include: blurred vision, bitter taste, dysgeusia, and sour taste. See below for a comprehensive list of adverse effects.

Renal Dose Adjustments

Severe renal impairment (CrCl less than 30 mL/min): Not recommended

Other Comments

Patient advice:
-To minimize systemic absorption, pressure should be applied to the tear duct for two minutes immediately after administration.
-Patients should be instructed to avoid allowing the tip of the container to contact the eye, eyelid, fingers or any other surface.

Storage requirements:
-Store at 4 C to 30 C (39 F to 86 F)
-Shake well before use.
-Discard container 4 weeks after opening.

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