Bloxiverz

Neostigmine methylsulfate is a prescription medication used to reverse the effects of nerve blocking drugs that are used during surgery.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.
 

• Eclat Pharmaceuticals, LLC

Common side effects of neostigmine methylsulfate include a slower heart beat, nausea, and vomiting.

This is not a complete list of neostigmine methylsulfate side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
 

• If you have an allergy to neostigmine or any other part of Bloxiverz (neostigmine injection).
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have any of these health problems: Bowel block, peritonitis, or trouble passing urine.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Bloxiverz with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Use Bloxiverz as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• It is given as a shot into a muscle, vein, or into the fatty part of the skin.
• It is given into a vein for a period of time.
• Other drugs may be given before this medicine to help avoid side effects.

What do I do if I miss a dose?

• Call your doctor to find out what to do.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Stomach cramps.
• Loose stools (diarrhea).
• Drooling.
• Headache.
• Dizziness.
• Upset stomach or throwing up.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

Applies to neostigmine: oral tablet

Other dosage forms:

• injection injectable, injection solution

Along with its needed effects, neostigmine (the active ingredient contained in Bloxiverz) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking neostigmine:

• Twitches of the muscle visible under the skin

• Blurred or loss of vision
• changes in patterns and rhythms of speech
• chest pain or discomfort
• confusion
• cough
• difficult or labored breathing
• difficulty in moving
• difficulty swallowing
• disturbed color perception
• dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
• double vision
• fast, pounding, or irregular heartbeat or pulse
• halos around lights
• hives
• irregular, fast or slow, or shallow breathing
• itching
• lightheadedness, dizziness, or fainting
• loss of consciousness
• muscle cramps and spasms
• muscle pain or stiffness
• night blindness
• no blood pressure or pulse
• noisy breathing
• overbright appearance of lights
• pain in joints
• pale or blue lips, fingernails, or skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• seizures
• shortness of breath
• skin rash
• slow or irregular heartbeat
• slurred speech
• stopping of heart
• sweating
• tightness in chest
• trouble in speaking
• tunnel vision
• unconsciousness
• unusual tiredness or weakness
• wheezing

Get emergency help immediately if any of the following symptoms of overdose occur while taking neostigmine:

• Constipation
• decreased sexual ability
• difficult urination
• dry mouth
• enlarged pupils
• muscle weakness

Some side effects of neostigmine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Increased watering of mouth

• Bloated
• constricted, pinpoint, or small pupils (black part of eye)
• diarrhea
• drowsiness
• excess air or gas in stomach or intestines
• feeling of warmth
• full feeling
• headache
• increase in mucous from lungs
• increased need to urinate
• increased sweating
• nausea
• passing gas
• passing urine more often
• redness of skin
• redness of the face, neck, arms and occasionally, upper chest
• skin rash
• stomach cramps
• vomiting

Caution is recommended Excreted into human milk: Unknown Excreted into animal milk: Unknown The effects in the nursing infant are unknown.