Belladonna
Name: Belladonna
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What is belladonna?
Belladonna is a naturally occurring mixture.
Belladonna produces many effects in the body, including relief from spasms of the gastrointestinal tract (stomach and intestines), the bladder, and the biliary tract. This is helpful in controlling conditions such as colitis, spastic bladder, diverticulitis, infant colic, renal and biliary colic, peptic ulcer, and irritable bowel syndrome.
Belladonna also reduces the secretions of many organs, thereby helping to control conditions such as excessive stomach acid production.
Belladonna is used to treat the rigidity, tremor, excessive salivation, and sweating caused by Parkinson's disease.
Belladonna also is used to treat motion sickness, nausea, vomiting, abdominal cramping associated with menstruation, and to reduce nighttime urination.
Belladonna may also be used for purposes other than those listed in this medication guide.
Uses for Belladonna
Peptic Ulcer Disease
Adjunct in the treatment of peptic ulcer disease; however, no conclusive data that it aids in the healing, decreases the rate of recurrence, or prevents complications of peptic ulcers.a b h i With the advent of more effective therapies for the treatment of peptic ulcer disease, antimuscarinics have only limited usefulness in this condition.a
Has been used in combination with other drugs (e.g., phenobarbital);a b h i however, no data support superiority of combination preparations over antimuscarinics alone.a
GI Motility Disorders
Treatment of functional disturbances of GI motility (e.g., irritable bowel syndrome) and neurogenic bowel disturbances;a however, efficacy is limited.a Use only if other measures (e.g., diet, sedation, counseling, amelioration of environmental factors) have been of little or no benefit.a
Has been used in combination with other drugs (e.g., phenobarbital) in the treatment of functional disturbances of GI motility such as irritable bowel syndrome;a b h i however, such combined therapy lacks substantial evidence of efficacy.a
Use with extreme caution, if at all, in the treatment of hypermotility and diarrhea associated with GI disorders such as acute enterocolitis.a
Pain
Has been used rectally in combination with opium in patients unresponsive to nonopiate analgesics for symptomatic relief of moderate to severe pain following GU surgery and for relief of pain caused by ureteral spasm. a g
Parkinsonian Syndrome
Treatment of mild cases of parkinsonian syndrome or as an adjunct to other therapy; however, antimuscarinics generally have been replaced with dopaminergic drugs.a
Interactions for Belladonna
Drugs with Anticholinergic Effects
Additive adverse effects resulting from cholinergic blockade (e.g., xerostomia, blurred vision, constipation).c Advise of possibility of increased anticholinergic effects and monitor carefully. c
Effects on GI Absorption of Drugs
By inhibiting the motility of the GI tract and prolonging GI transit time, antimuscarinics have the potential to alter GI absorption of various drugs.c
Specific Drugs
| Drug | Interaction | Comments |
|---|---|---|
| Amantadine | Additive anticholinergic effectsc | Inform patient of this possibilityc |
| Antacids | May interfere with belladonna absorptionc | Administer belladonna at least 1 hour before antacidsc |
| Antiarrhythmic (anticholinergic) agents | Additive anticholinergic effectsc | Inform patient of this possibilityc |
| Antidepressants, tricyclic | Additive anticholinergic effectsc | Inform patient of this possibilityc |
| Antihistamines (anticholinergic) (including meclizine) | Additive anticholinergic effectsc | Inform patient of this possibilityc |
| Antiparkinsonian (antimuscarinic) agents | Additive anticholinergic effectsc | Inform patient of this possibilityc |
| Corticosteroids | Possible increased IOPc |
|
| Digoxin (slow dissolving) | Possible increased serum digoxin concentrationc | Use digoxin oral solution (elixir) or rapidly dissolving tablets (e.g., Lanoxin)c Observe closely for signs of digitalis toxicityc |
| Glutethimide | Additive anticholinergic effectsc | Inform patient of this possibilityc |
| Ketoconazole | Increased gastric pH decreases ketoconazole absorptionc | Administer belladonna at least 2 hours after ketoconazolec |
| Levodopa | Possible increased GI metabolism of levodopa and decreased systemic concentrationsc | Adjust levodopa dosage if belladonna is started or discontinuedc |
| Meperidine | Additive anticholinergic effectsc | Inform patient of this possibilityc |
| Muscle (anticholinergic) relaxants | Additive anticholinergic effectsc | Inform patient of this possibilityc |
| Phenothiazines | Additive anticholinergic effectsc | Inform patient of this possibilityc |
| Potassium chloride | Slowed GI transit potentiates adverse GI effects of oral potassium chloride (especially wax-matrix tablets)c | Caution if used concomitantly; monitor for possible GI mucosal lesionsc |
Preparations
Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.
Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
| Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
| Bulk | Leaf* | USP (with at least 0.35% w/w of the alkaloids) | ||
| Oral | Tincture* | 0.3 mg of the alkaloids of belladonna leaf per mL with alcohol 67% |
| Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
| Oral | Solution | Atropine Sulfate 0.0194 mg/5 mL, Hyoscyamine Sulfate 0.1037 mg/5 mL, Phenobarbital 16.2 mg/5 mL, and Scopolamine Hydrobromide 0.0065 mg/5 mL | Donnatal Elixir | PBM |
| Phenobarb with Belladonna Alkaloids Elixir | Vintage | |||
| Tablets | Atropine Sulfate 0.0194 mg, Hyoscyamine Sulfate 0.1037 mg, Phenobarbital 16.2 mg, and Scopolamine Hydrobromide 0.0065 mg | Belladonna Alkaloids with Phenobarb Tablets | ||
| Donnatal | PBM | |||
| Hyonatol | Western Research | |||
| Tablets, extended-release | Atropine Sulfate 0.0582 mg, Hyoscyamine Sulfate 0.3111 mg, Phenobarbital 48.6 mg, and Scopolamine Hydrobromide 0.0195 mg | Donnatal Extentabs | PBM |
* available from one or more manufacturer, distributor, and/or repackager by generic (nonproprietary) name
| Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
| Bulk | Powder* |
| Routes | Dosage Forms | Strengths | Brand Names | Manufacturer |
|---|---|---|---|---|
| Rectal | Suppositories | 16.2 mg (0.21 mg of the alkaloids of belladonna leaf) with Powdered Opium 30 mg | Belladonna & Opium Suppositories (C-II) | |
| B & O Supprettes No. 15A (C-II) | PolyMedica | |||
| 16.2 mg (0.21 mg of the alkaloids of belladonna leaf) with Powdered Opium 60 mg | Belladonna & Opium Suppositories (C-II) | |||
| B & O Supprettes No. 16A (C-II) | PolyMedica |
Uses
Consult your pharmacist.
How to use Belladonna Liquid
Consult your pharmacist.
Side Effects
Consult your pharmacist.
In the US -
Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088 or at www.fda.gov/medwatch.
In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.
List Belladonna Liquid side effects by likelihood and severity.Precautions
Consult your pharmacist.
Interactions
Consult your pharmacist.
Keep a list of all your medications with you, and share the list with your doctor and pharmacist.
Administrative Information
LactMed Record Number
943
Last Revision Date
20170411
Disclaimer
Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.