Bendroflumethiazide and nadolol

Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not use this medicine in larger or smaller amounts or for longer than recommended.

You may take bendroflumethiazide and nadolol with or without food.

You may have very low blood pressure while taking this medicine. Call your doctor if you are sick with vomiting or diarrhea, or if you are sweating more than usual. Prolonged illness can lead to a serious electrolyte imbalance, making it dangerous for you to use bendroflumethiazide and nadolol.

Keep using this medicine as directed. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Your blood pressure will need to be checked often. Your blood and urine may both be tested if you have been vomiting or are dehydrated.

Do not stop using this medicine suddenly, even if you feel fine. Stopping suddenly may cause serious or life-threatening heart problems. Follow your doctor's instructions about tapering your dose.

If you need surgery or medical tests, tell the doctor ahead of time that you are taking bendroflumethiazide and nadolol. You may need to stop using the medicine for a short time.

If you are diabetic, check your blood sugar carefully. Taking a beta-blocker may make it harder for you to tell when you have low blood sugar. Your insulin or diabetes medication needs may change while you are taking bendroflumethiazide and propranolol. Do not change your medication dose or schedule without your doctor's advice.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

Drinking alcohol with this medicine can cause side effects.

Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.

Initial dose: Bendroflumethiazide 5 mg-Nadolol 40 mg orally once a day
Maintenance dose: Bendroflumethiazide 5 mg-Nadolol 40 to 80 mg orally once a day

Use: Treatment of hypertension if the fixed dose combination represents an appropriate dose for the individual patient.

Data not available

Monitoring:
-Metabolic: Serum electrolytes periodically

Patient advice:
-Caution patients against interruption or cessation of therapy without a physician's advice.

This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus. US FDA pregnancy category: C

Animal studies with bendroflumethiazide have not been reported. Animal studies with nadolol have revealed evidence of embryotoxicity and fetotoxicity, but no teratogenicity. In humans, neonates whose mothers received nadolol at parturition exhibited bradycardia, hypoglycemia, and associated symptoms. There are no controlled data in human pregnancy. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.