Aveeno Baby Calming Comfort

• It is used to treat skin irritation.
• It is used to treat diaper rash.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if you have any side effects that bother you or do not go away.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

• Store at room temperature.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

There is no available information on appropriate human doses of this plant growth hormone.

Cytokinins are N 6 -substituted adenine derivatives. 6 The furfuryl moiety of kinetin is reported to originate from furfural, a primary oxidation product of the deoxyribose in DNA. 7 N 6 -furfuryladenine has electrochemical properties. Electrochemical assignments have been confirmed from kinetin using mass-spectrometric analysis. 2

Studies have reported the following: Isolation of kinetin from autoclaved water slurries of DNA, structure determination, and physiologic activity at high dilutions in the presence of auxin. 1

Cytokinins function as essential growth hormones, which can influence cell growth and differentiation in plant and non-plant tissues. 6 , 7 Kinetin can be formed in vivo, neutralizing harmful properties of hydroxyl radical reaction products. This is a defense mechanism in response to oxidative stress of cells. 8 Degradation of sugar residues in DNA is a major route of this cellular damage. 7 Kinetin-activated, major nucleolar organizer regions in basal, equatorial, and near-apical tissue of onion (leaf base) suggest it to be a regulator. 9

Cosmetic effects

The skin care product Kinerase claims to be a “nature-identical” plant growth factor, which “delays and improves unwanted changes in appearance and texture of photodamaged skin.” It allegedly reduces wrinkles and improves skin texture, telangiectasia, and mottled hyperpigmentation.

Animal data

Single-celled yeast, Saccharomyces cerevisiae , used as a model, demonstrated spore formation at micromolar concentrations of kinetin. 6 Another report finds kinetin to delay aging and prolong lifespan of the fruitfly Zaprionus paravittiger . 10 Addition of kinetin in a culture medium of human cells can delay and offset aging characteristics such as growth rate and cell size. 11 The amount of DNA in the nuclei of the fibroblast cells increased in the presence of kinetin from human skin. 12

Clinical data

Results are typically seen in 4 to 6 weeks. Product literature compares Kinerase with the prescription cream Renova (0.05% tretinoin), finding Kinerase to be superior to Renova parameters by patient self-assessment at a 24-week period. There was an incidence of side effects using Kinerase vs Renova (eg, erythema, peeling, burning, and stinging). 5

1. Budavari S, O'Neil MJ, Smith A, Heckelman PE, eds. The Merck Index 11th ed . Rahway, NJ: Merck & Co., Inc. 1989;837.
2. Barciszewski J, Siboska GE, Pedersen BO, Clark BF, Rattan SI. Evidence for the presence of kinetin in DNA and cell extracts. FEBS Lett . 1996;393:197-200.
3. Starr C, Taggart R. Biology The Unity and Diversity of Life, 4th ed . Belmont, CA: Wadsworth Publishing Co. 1987;286.
4. Arms K, Camp PS. Biology, 2nd ed . New York, NY: Saunders Publishing, Co. 1982:786.
5. Kinerase product information. Available at: http://www.dermcosmetic.com/kinerase.html . Accessed July 12, 1999.
6. Laten HM. Cytokinins affect spore formation but not cell division in the yeast Saccharomyces cerevisiae . Biochimica et Biophysica Acta . 1995;1266:45-49.
7. Barciszewski J, Siboska GE, Pedersen BO, Clark BF, Rattan SI. Furfural, a precursor of the cytokinin hormone kinetin, and base propenals are formed by hydroxyl radical damage of DNA. Biochem Biophys Res Commun . 1997;238:317-319.
8. Barciszewski J, Siboska GE, Pedersen BO, Clark BF, Rattan SI. A mechanism for the in vivo formation of N6-furfuryladenine, kinetin, as a secondary oxidative damage product of DNA. FEBS Lett . 1997;414:457-460.
9. Karagiannis CS, Pappelis AJ. Effect of abscisic acid, gibberellic acid, indoleacetic acid, and kinetin on selective ribosomal cistron regulation in quiescent and senescent onion leaf base tissue. Mech Ageing Dev . 1994;76:145-155.
10. Sharma SP, Kaur P, Rattan SI. Plant growth hormone kinetin delays ageing, prolongs the lifespan, and slows down development of the fruitfly Zaprionus paravittiger . Biochem Biophys Res Commun . 1995;216:1067-1071.
11. Rattan SI, Clark BF. Kinetin delays the onset of ageing characteristics in human fibroblasts. Biochem Biophys Res Commun . 1994;201:665-672.
12. Kowalska E. Influence of kinetin (6-furfurylo-amino-purine) on human fibroblasts in the cell culture. Folia Morphol (Warsz) . 1992;51:109-118.

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