Name: Atropine

Side effects

Most of the side effects of atropine are directly related to its antimuscarinic action. Dryness of the mouth, blurred vision, photophobia and tachycardia commonly occur with chronic administration of therapeutic doses. Anhidrosis also may occur and produce heat intolerance or impair temperature regulation in persons living in a hot environment. Constipation and difficulty in micturition may occur in elderly patients. Occasional hypersensitivity reactions have been observed, especially skin rashes which in some instances progressed to exfoliation.

Adverse effects following single or repeated injections of atropine are most often the result of excessive dosage. These include palpitation, dilated pupils, difficulty in swallowing, hot dry skin, thirst, dizziness, restlessness, tremor, fatigue and ataxia. Toxic doses lead to marked palpitation, restlessness and excitement, hallucinations, delirium and coma. Depression and circulatory collapse occur only with severe intoxication. In such cases, blood pressure declines and death due to respiratory failure may ensue following paralysis and coma.

Atropine Brand Names

Atropine may be found in some form under the following brand names:

  • Antispas

  • Antrocol

  • Atreza

  • Atrohist Plus

  • AtroPen

  • Atropine-Care

  • Atropisol

  • Atrosept

  • Atrosulf-1

  • Barbidonna

  • Barophen

  • Bellalphen

  • Bellatal

  • Chardonna-2

  • Colidrops

  • Cystemms-V

  • D-Tal

  • Deconhist LA

  • Di-Atro

  • Dimotal

  • Dolsed

  • Donnaphen

  • Donnapine

  • Donnatal

  • Duodote

  • Elixiral

  • Ex-Tuss

  • Haponal

  • Hyosophen

  • Hypersed

  • Isopto Atropine

  • Lomocot

  • Lomotil

  • Lonox

  • Malatal

  • Mhp-a

  • Motofen

  • Ocu-Tropine

  • Phenchlor S.H.A.

  • Phenobel

  • Protuss Tablet

  • Q-Tuss

  • Respa-A.R.M.

  • Rolatuss-SR

  • Ru-Tab

  • Rutuss

  • Sal-Tropine

  • Servira

  • Spasmolin

  • Spasquid

  • Spastolate

  • Stahist

  • Stahist Reformulated Apr 2013

  • Trac Tabs 2x

  • Uaa

  • Urapine

  • Uretron

  • Uri-Sep SC

  • Uridon Modified

  • Urimar T

  • Urised

  • Uritin

  • Usept

  • Vi-Atro

Atropine Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Anti-arrhythmia medications such as procainamide (Procanbid, Procan), disopyramide (Norpace, Rythmodan), quinidine, and digoxin (Lanoxin)
  • Anticholinergic agents 
  • Antihistamines such as diphenhydramine (Benadryl)
  • Antipsychotics such as paliperidone (Invega), lurasidone (Latuda), olanzapine (Zyprexa), aripiprazole (Abilify), asenapine (Saphris), iloperidone (Fanapt), haloperidol (Haldol), prochlorperazine (Compazine), chlorpromazine (Thorazine), clozapine (Clozaril), risperidone (Risperdal), quetiapine (Seroquel), and ziprasidone (Geodon)
  • Benzodiazepines such as diazepam (Valium), lorazepam (Ativan), alprazolam (Xanax), and midazolam (Versed)
  • Methylphenidate (Concerta, Methylin, Ritalin)
  • Metoclopramide (Reglan and others)
  • Monoamine oxidase inhibitors such as tranylcypromine (Parnate), phenelzine (Nardil), selegiline (Eldepryl, Zelapar), isocarboxazid (Marplan), and rasagiline (Azilect)
  • Nitrofurantoin (Macrobid)
  • Tricyclic antidepressants such as trimipramine (Surmontil), amitriptyline (Elavil), nortriptyline (Pamelor, Aventyl), protriptyline (Vivactil), and clomipramine (Anafranil)

This is not a complete list of atropine drug interactions. Ask your doctor or pharmacist for more information.

Atropine and Pregnancy

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.


Atropine injection falls into category B.

There are no well-done studies that have been done in humans with atropine. In animal studies, pregnant animals were given this medication, and the babies did not show any medical issues related to this medication.


Atropine ophthalmic ointment and solution fall into category C.

No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Atropine should be given to a pregnant woman only if clearly needed.





25°C (may be exposed to 15–30°C).105

Protect from freezing and light.105


For information on systemic interactions resulting from concomitant use, see Interactions.


Solution CompatibilityHID


Sodium chloride 0.9%

Drug Compatibility Admixture CompatibilityHID


Dobutamine HCl



Sodium bicarbonate

Verapamil HCl

Y-Site CompatibilityHID



Amiodarone HCl



Dexmedetomidine HCl




Fenoldopam mesylate

Fentanyl citrate

Heparin sodium

Hydrocortisone sodium succinate

Hydromorphone HCl


Methadone HCl

Morphine sulfate

Nafcillin sodium

Palonosetron HCI

Potassium chloride

Tirofiban HCl



Compatibility in SyringeHID


Buprenorphine HCl

Butorphanol tartrate

Chlorpromazine HCl


Diphenhydramine HCl


Fentanyl citrate


Heparin sodium

Hydromorphone HCl

Hydroxyzine HCl

Meperidine HCl

Metoclopramide HCl

Midazolam HCl

Milrinone lactate

Morphine sulfate

Nalbuphine HCl

Ondansetron HCl

Pentazocine lactate

Prochlorperazine edisylate

Promethazine HCl

Ranitidine HCl

Scopolamine HBr


Pantoprazole sodium


Pentobarbital sodium

Uses For Atropine

Ophthalmic atropine, homatropine, and scopolamine are used to dilate (enlarge) the pupil of the eye. They are used before eye examinations, before and after eye surgery, and to treat certain eye conditions, such as uveitis or posterior synechiae.

These medicines are available only with your doctor's prescription.

Precautions While Using Atropine

After you apply this medicine to your eyes:

  • Your pupils will become unusually large and you will have blurring of vision, especially for close objects. Make sure your vision is clear before you drive, use machines, or do anything else that could be dangerous if you are not able to see well.
  • Your eyes will become more sensitive to light than they are normally. Wear sunglasses to protect your eyes from sunlight and other bright lights.

These effects may continue for several days after you stop using this medicine. However, check with your doctor if they continue longer than:

  • 14 days if you are using atropine.
  • 3 days if you are using homatropine.
  • 7 days if you are using scopolamine.

Indications and Usage for Atropine

Atropine Sulfate Injection, USP, is indicated for temporary blockade of severe or life threatening muscarinic effects, e.g., as an antisialagogue, an antivagal agent, an antidote for organophosphorus or muscarinic mushroom poisoning, and to treat bradyasystolic cardiac arrest.

Atropine Dosage and Administration

General Administration

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Do not administer unless solution is clear and seal is intact. Discard unused portion.

For intravenous administration.

Titrate based on heart rate, PR interval, blood pressure and symptoms.

Adult Dosage

Table 1: Recommended Dosage
Use Dose (adults) Repeat
Antisialagogue or other antivagal 0.5 to 1 mg 1–2 hours
Organophosphorus or muscarinic mushroom poisoning 2 to 3 mg 20–30 minutes
Bradyasystolic cardiac arrest 1 mg 3–5 minutes; 3 mg maximum total dose

Pediatric Dosage

Dosing in pediatric populations has not been well studied. Usual initial dose is 0.01 to 0.03 mg/kg.

Dosage Forms and Strengths

Injection: 0.1 mg/mL in LifeShield™ Abboject™ Glass Syringes

PRINCIPAL DISPLAY PANEL - 0.5 mg Syringe Label

Atropine Sulfate 0.1 mg/mL

5 mL Single-dose
NDC 0409-4910-34

Atropine SULFATE Inj., USP
0.5 mg (0.1 mg/mL)

Rx only

For I.V., I.M. or S.C. use. Usual dosage:
See insert. Sterile, nonpyrogenic.

Hospira, Inc., Lake Forest, IL 60045 USA


RL-0260 (9/04)