Anti-D (rh) immunoglobulin

Anti-D (rh) immunoglobulin is a prescription medication used to prevent Rh immunization, also known as Rh incompatibility.

Anti-D (rh) immunoglobulin can also be used to treat immune thrombocytopenia purpura (ITP), a bleeding disorder, in adults.

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information.

anti-D (rh) immunoglobulin may be found in some form under the following brand names:

• BayRHo-D

• HyperRHO

• MICRhoGAM

• RhoGAM

• Rhophylac

• WinRho SDF

anti-D (rh) immunoglobulin is part of the drug class:

• Specific immunoglobulins

Serious side effects have been reported with anti-D (rh) immunoglobulin. See the “Drug Precautions” section.

The most common side effect is injection site reactions that may include swelling, induration, redness, and mild pain or warmth.

Common side effects of anti-D (rh) immunoglobulin for prevention of Rh immunization include:

• nausea
• dizziness
• headache
• injection-site pain
• malaise

Common side effects of anti-D (rh) immunoglobulin for treatment of ITP include:

• chills
• fever
• headache
• bleeding disorders

This is not a complete list of side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you require immunizations. Anti-D (rh) immunoglobulin may impair the efficacy of live vaccines such as measles, mumps, and varicella. Administration of live vaccines should generally be delayed until 12 weeks after the final dose of anti-D (rh) immunoglobulin. If aAnti-D (rh) immunoglobulin is administered within 14 days after administration of a live vaccine, the efficacy of the vaccination may be impaired. The postpartum vaccination of rubella-susceptible women with rubella or MMR vaccine should not be delayed because of the receipt of anti-D (rh) immunoglobulin.

This is not a complete list of drug interactions. Ask your doctor or pharmacist for more information.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X – are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Anti-D (rh) immunoglobulin falls into category C. No studies have been done in animals, and no well-controlled studies have been done in pregnant women. Anti-D (rh) immunoglobulin  should be given to a pregnant woman only if clearly needed.