Astagraf

Before you take tacrolimus, tell your doctor if you:

• plan to receive any live vaccines
• have or have had liver, kidney or heart problems
• are pregnant or plan to become pregnant. Tacrolimus may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.
• are breastfeeding or plan to breastfeed. Tacrolimus can pass into your breast milk. You and your doctor should decide if you will take tacrolimus or breastfeed. You should not do both. 

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Tell your doctor if you are pregnant or plan to become pregnant. Tacrolimus may harm your unborn baby. Talk to your doctor if you are pregnant or plan to become pregnant.

BOX WARNING - MALIGNANCIES AND SERIOUS INFECTIONS

• Increased risk of development of lymphoma and other malignancies, particularly of the skin, due to immunosuppression.
• Increased susceptibility to bacterial, viral, fungal, and protozoal infections, including opportunistic infections.
• Only physicians experienced in immunosuppressive therapy and management of organ transplant patients should prescribe tacrolimus. Patients receiving the drug should be managed in facilities equipped and staffed with adequate laboratory and supportive medical resources. The physician responsible for maintenance therapy should have complete information requisite for the follow-up of the patient.