Agri-Mectin

Ivermectin lotion is a prescription medication used to treat head lice infestations in adults and children 6 months of age and older.

The ivermectin tablet is a prescription medication used to treat strongyloidiasis (threadworm; infection with a type of roundworm that enters the body through the skin, moves through the airways and lives in the intestines) and to control onchocerciasis (river blindness; infection with a type of roundworm that may cause rash, bumps under the skin, and vision problems including vision loss or blindness).

Ivermectin cream is used for the treatment of inflammatory lesions, or bumps and pimples, of rosacea. 

This medication may be prescribed for other uses. Ask your doctor or pharmacist for more information. 

Oral:

• Ivermectin comes as a tablet to take by mouth. It is usually taken as a single dose on an empty stomach with water. If you are taking ivermectin to treat onchocerciasis, additional doses 3, 6, or 12 months later may be necessary to control your infection. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take ivermectin exactly as directed. Do not take more or less of it or take it more often than prescribed by your doctor.
• If you are taking ivermectin to treat strongyloidiasis, you will need to have a stool exam at least three times during the first 3 months after your treatment to see if your infection has cleared. If your infection has not cleared, your doctor will probably prescribe additional doses of ivermectin.
• Ivermectin tablets are usually taken as a single dose. Tell your doctor if you do not take your medication.

Topical:

• Use ivermection lotion exactly as prescribed. Your healthcare provider will prescribe the treatment that is right for you. Do not change your treatment unless you talk to your healthcare provider.
• Use ivermection lotion when your hair is dry.
• It is important to use enough ivermection lotion to completely coat all of your hair and scalp. Leave lotion on your hair and scalp for a full 10 minutes.
• You need to completely cover all the scalp and hair with lotion.
• Children will need an adult to apply ivermection lotion for them.
• Do not swallow ivermection lotion. If swallowed, call your healthcare provider or go to the nearest emergency room right away.
• Do not get ivermection lotion into your eyes. If ivermection lotion gets in your eye, gently flush with water.
• Wash your hands after applying ivermection lotion.

When you complete your dose of ivermection lotion, do not use ivermection lotion again without talking to your healthcare provider first.

Before you use ivermection lotion, ask your healthcare provider or pharmacist if you have questions about the right way to use ivermection lotion.

• Your hair and scalp must be dry before applying ivermection lotion.
• Use the top of cap to break the tamper seal on the tube.
• Apply ivermection lotion directly to dry hair and scalp.
• Completely cover your scalp and hair closest to the scalp first, and then apply outwards towards the ends of your hair.
• Rub ivermection lotion throughout hair.
• It is important to completely cover your entire head so that all lice and eggs are exposed to the lotion. Be sure that each hair is coated from the scalp to the tip.
• Use up to 1 entire tube (4 oz) to completely cover hair and scalp.
• Allow ivermection lotion to stay on your hair and scalp for 10 minutes after it has been applied. Use a timer or clock. Start timing after you have completely covered your hair and scalp with ivermection lotion.
• After 10 minutes, completely rinse ivermection lotion from your hair and scalp using only water.
• You or anyone who helps you apply ivermection lotion should wash their hands after application.
• Do not use ivermection lotion again without talking to your healthcare provider first.

To help prevent the spread of lice from one person to another, here are some steps you can take:

• Avoid direct head-to-head contact with anyone known to have live, crawling lice.
• Do not share combs, brushes, hats, scarves, bandannas, ribbons, barrettes, hair bands, towels, helmets, or other hair-related personal items with anyone else, whether they have lice or not.
• Avoid sleepovers and slumber parties during lice outbreaks. Lice can live in bedding, pillows, and carpets that have recently been used by someone with lice.
• After finishing treatment with lice medicine, check everyone in your family for lice after one week. Be sure to talk to your healthcare provider about treatments for those who have lice.
• Machine wash any bedding and clothing used by anyone having lice. Machine wash at high temperatures (150°F) and tumble in a hot dryer for 20 minutes.

Oral:

• Store tablets at room temperature and away from excess heat and moisture (not in the bathroom).
• Keep ivermectin tablets and all medicines out of reach of children.

Topical:

• Store ivermectin lotion at room temperature between 68° to 77°F (20° to 25°C).
• Do not freeze ivermectin lotion.
• Safely throw away any unused ivermectin lotion.
• Keep ivermectin lotion and all medicines out of reach of children.

Contains 5 mg ivermectin/mL
ANADA 200-272, Approved by FDA

Agri-Mectin® (ivermectin) Pour-On delivers internal and external parasite control in one convenient low-volume application.

Ivermectin is a member of the macrocylic lactone class of endectocides which have a unique mode of action. Compounds of the class bind selectively and with high affinity to glutamate-gated chloride ion channels which occur in invertebrate nerve and muscle cells.

This leads to an increase in the permeability of the cell membrane to chloride ions with hyperpolarization of the nerve or muscle cell, resulting in paralysis and death of the parasite. Compounds of this class may also interact with other ligand -gated chloride channels, such as those gated by the neurotransmitter gamma-aminobutyric acid (GABA).

The margin of safety for compounds of this class is attributable to the fact that mammals do not have glutamate-gated chloride channels, the macrocylic lactones have a low affinity for other mammalian ligand-gated chloride channels and they do not readily cross the blood-brain barrier.

Studies conducted in the U.S.A. have demonstrated the safety margin for ivermectin. Based on plasma levels, the topically applied formulation is expected to be at least as well tolerated by breeding animals as is the subcutaneous formulation which had no effect on breeding performance.

RESIDUE INFORMATION: Cattle must not be treated within 48 days of slaughter for human consumption. Because a withdrawal time in milk has not been established, do not use in female dairy cattle of breeding age. A withdrawal period has not been established for this product in pre-ruminating calves. Do not use in calves to be processed for veal.

Studies indicate that when ivermectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time. Free ivermectin may adversely affect fish or certain aquatic organisms. Do not permit cattle to enter lakes, streams or ponds for at least six hours after treatment. Do not contaminate water by direct application or by the improper disposal of drug containers. Dispose of containers in an approved landfill or by incineration.

As with other avermectins, ivermectin is excreted in the dung of treated animals and can inhibit the reproduction and growth of pest and beneficial insects that use dung as a source of food and for reproduction. The magnitude and duration of such effects are species and life-cycle specific. When used according to label directions, the product is not expected to have an adverse impact on populations of dung-dependent insects.