Adrenalin Chloride

Injectable Solution of 0.1 mg/mL (1:10,000):
-IV: 0.5 to 1 mg (5 to 10 mL) IV once; during resuscitation effort, 0.5 mg (5 mL) should be given IV every 5 minutes
-Intracardiac: 0.3 to 0.5 mg (3 to 5 mL) via intracardiac injection into left ventricular chamber once
-Endotracheal: 0.5 to 1 mg (5 mL to 10 mL) via endotracheal tube directly into bronchial tree once

Comments:
-Intracardiac injection should only be administered by personnel well trained in this technique and only if there has not been sufficient time to establish an IV route.

Use: For prophylaxis and treatment of cardiac arrest and attacks of transitory atrioventricular heart block with syncopal seizures (Stokes-Adams Syndrome)

The American Heart Association (AHA) recommends:
-IV or intraosseous: 1 mg IV or intraosseous every 3 to 5 minutes during cardiac arrest
-Endotracheal: 2 to 2.5 mg endotracheally every 3 to 5 minutes during cardiac arrest if IV or intraosseous route cannot be established

Use: For administration during cardiac arrest

Injectable Solution of 0.1 mg/mL (1:10,000):
-Neonate: 0.01 mg/kg IV slowly once
-Infant: 0.05 mg IV slowly once; may repeat at 20 to 30 minute intervals as needed

Use: For the treatment of acute asthmatic attacks to relieve bronchospasm not controlled by inhalation or subcutaneous administration of other solutions of the drug

Data not available

Consult WARNINGS section for additional precautions.

Data not available

Administration Advice:
-Consult specific manufacturer product information for administration instructions.
-Auto-injector: For single use only; inspect for particulate matter and discoloration; insert IM or subcutaneously into the anterolateral aspect of the thigh, through clothing if necessary; if the patient is a child, hold the leg firmly in place to limit movement prior to and during injection.
-Adrenalin(R): Not for ophthalmic use.
-Inspect visually for particulate matter and discoloration prior to administration, whenever solution and container permit; do not use if solution is colored, cloudy, or contains particulate matter.

Storage requirements:
-Auto-injector: Store in outer case provided to protect from light; store at room temperature; do not refrigerate.
-Injectable Solution: Protect from light and freezing; store at room temperature; multiple-use vial must be discarded 30 days after initial use.
-Ampule: Store at room temperature; protect from light, freezing, and alkalis and oxidizing agents.

Reconstitution/preparation techniques:
-The manufacturer product information should be consulted.

Patient advice:
-There is a possibility of recurrence of anaphylaxis symptoms after a good response to initial treatment; obtain medical attention following use of this drug.
-Consult patient information leaflet for further advice.