Name: Accupril

Quinapril Side Effects

Common Side Effects of Quinapril

Tell your doctor if any of the following side effects become severe or don't go away:

  • Cough
  • Mild dizziness or nausea
  • Tiredness
  • Mild headache

Serious Side Effects of Quinapril

Tell your doctor right away if you experience any of the symptoms listed in the Quinapril Warnings section above, or any of the following serious side effects:

  • Severe dizziness
  • Lightheadedness or fainting
  • Decreased urination
  • Red, swollen, blistered, or peeling skin
  • Pale skin
  • Unusual bleeding or bruising
  • Stomach pain
  • Severe nausea
  • Yellowing of the skin or eyes
  • Dark-colored urine
  • Pale-colored stools
  • Confusion
  • Mental or mood changes
  • Fast, slow, or irregular heartbeat
  • Shortness of breath
  • Unusual tiredness or fatigue
  • Chest, jaw, or arm pain
  • Slurred speech
  • Sudden, severe headache
  • Muscle pain, weakness, or cramping
  • Burning, numbness, or tingling
  • Weakness on one side of the body
  • Numbness of an arm or leg
  • Loss of appetite
  • Vision changes
  • Unusual sweating
  • Swelling of the hands, ankles, feet, or lower legs
  • Sudden weight gain
  • Signs of an infection, which may include fever, chills, sore throat, body aches, or other flu-like symptoms
  • Signs of a severe allergic reaction, which may include itching, hives, rash, difficulty swallowing or breathing, hoarseness, chest tightness, or swelling of the mouth, face, lips, tongue, or throat

Quinapril Interactions

Tell your doctor about all prescription, nonprescription, illegal, recreational, herbal, nutritional, or dietary drugs you're taking, especially those listed in the Quinapril Warnings section above, and any of the following:

  • Antibiotics, such as Oracea, Monodox, or Vibramycin (doxycycline), Sumycin (tetracycline), or Cipro (ciprofloxacin)
  • Diuretics (water pills)
  • Lithobid (lithium)
  • Nonsteroidal anti-inflammatory drugs (NSAIDs), such as Advil or Motrin (ibuprofen) and Indocin or Indo-Lemmon (indomethacin)
  • Insulin and other diabetes medicines
  • Gold injections for arthritis
  • Nonprescription medicines that contain stimulants (may include diet pills and cold medicines)
  • Angiotensin receptor blocker drugs, such as Cozaar (losartan), Avapro (irbesartan), and Diovan HCT (valsartan)

Quinapril and Other Interactions

Quinapril may cause dizziness or lightheadedness.

Use caution when driving, operating machinery, or performing other activities that require alertness.

Quinapril and Alcohol

Alcohol can lower your blood pressure and may increase the risk of certain side effects associated with quinapril.

Don't drink alcohol while using this medicine without first talking to your doctor.

How should I take quinapril?

Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Drink plenty of water each day while you are taking this medication.

Your blood pressure will need to be checked often, and you may need frequent blood tests.

Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking quinapril. This can lead to very low blood pressure, electrolyte disorders, or kidney failure.

If you need surgery, tell the surgeon ahead of time that you are using quinapril. You may need to stop using the medicine for a short time.

If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.

Store at room temperature away from moisture, heat, and light.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.


Nonsulfhydryl ACE inhibitor.1 2 3 47

Advice to Patients

  • Risk of angioedema, anaphylactoid reactions, or other sensitivity reactions.1 47 Importance of reporting sensitivity reactions (e.g., edema of face, eyes, lips, tongue, or extremities; hoarseness; swallowing or breathing with difficulty) immediately to clinician and of discontinuing the drug.1 47

  • Importance of reporting signs of infection (e.g., sore throat, fever).1 47

  • Risk of hypotension.1 47 Importance of informing clinicians promptly if lightheadedness or fainting occurs.1 47

  • Importance of adequate fluid intake; risk of volume depletion with excessive perspiration, dehydration, vomiting, or diarrhea.1 47

  • Risks of use during pregnancy.1 47 65 66 (See Boxed Warning.)

  • Importance of informing clinicians of existing or contemplated concomitant therapy, including prescription and OTC drugs (including salt substitutes containing potassium).1 47

  • Importance of women informing clinicians if they are or plan to become pregnant or plan to breast-feed.1 47

  • Importance of advising patients of other important precautionary information.1 47 (See Cautions.)

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Signs of a high potassium level like a heartbeat that does not feel normal; change in thinking clearly and with logic; feeling weak, lightheaded, or dizzy; feel like passing out; numbness or tingling; or shortness of breath.
  • Very bad dizziness or passing out.
  • Cough that does not go away.
  • Very bad belly pain.
  • Very upset stomach or throwing up.
  • Liver problems have happened with drugs like this one. Sometimes, this has been deadly. Call your doctor right away if you have signs of liver problems like dark urine, feeling tired, not hungry, upset stomach or stomach pain, light-colored stools, throwing up, or yellow skin or eyes.

If OVERDOSE is suspected

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.


Accupril is contraindicated in patients who are hypersensitive to this product and in patients with a history of angioedema related to previous treatment with an ACE inhibitor.

Accupril is contraindicated in combination with a neprilysin inhibitor (e.g., sacubitril). Do not administer Accupril within 36 hours of switching to or from sacubitril/valsartan, a neprilysin inhibitor (see WARNINGS and PRECAUTIONS).

Do not co-administer Accupril with aliskiren in patients with diabetes.

PRINCIPAL DISPLAY PANEL - 20 mg Tablet Bottle Label


NDC 0071-0532-23

(Quinapril HCl Tablets)

20 mg*

90 Tablets
Rx only

Accupril Drug Class

Accupril is part of the drug class:


Accupril Dosage

Take Accupril exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

High Blood Pressure: The recommended starting dose of Accupril for the treatment of high blood pressure is 10 mg or 20 mg once daily or divided into two smaller doses.

Congestive Heart Failure: The recommended starting dose of Accupril for the treatment of congestive heart failure is 5 mg twice a day.

Based on how your body responds to the medication and side effects you experience your healthcare provider may decide to increase or decrease your dose. The dose you receive is also based on the following factors:

  • your age
  • the medical condition you are being treated for
  • other medical conditions you may have 
  • other medications you are taking including diuretics

Accupril side effects

Get emergency medical help if you have any signs of an allergic reaction to Accupril: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

  • a light-headed feeling, like you might pass out;

  • little or no urination;

  • jaundice (yellowing of the skin or eyes);

  • high potassium - mausea, slow or unusual heart rate, weakness, loss of movement; or

  • signs of infection - sudden weakness or ill feeling, fever, chills, sore throat, painful mouth sores, pain when swallowing, skin sores, cold or flu symptoms.

Common Accupril side effects may include:

  • headache;

  • cough; or

  • dizziness, tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Accupril?

Other drugs may interact with quinapril, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.

Quinapril Breastfeeding Warnings

Use is not recommended. Excreted into human milk: Yes Comments: The effects in the nursing infant are unknown.