Verdrocet

Applies to acetaminophen / hydrocodone: oral capsule, oral elixir, oral liquid, oral solution, oral syrup, oral tablet

Along with its needed effects, acetaminophen/hydrocodone may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking acetaminophen / hydrocodone:

• Dizziness
• lightheadedness

• Back, leg, or stomach pains
• black, tarry stools
• bleeding gums
• blood in the urine or stools
• blood in vomit
• bluish lips or skin
• chills
• choking
• cough or hoarseness
• dark urine
• decrease in the frequency of urination
• decrease in urine volume
• difficult or troubled breathing
• difficulty in passing urine (dribbling)
• difficulty with breathing
• difficulty with swallowing
• fast heartbeat
• fever
• fever with or without chills
• general body swelling
• general feeling of tiredness or weakness
• headache
• irregular, fast or slow, or shallow breathing
• light-colored stools
• loss of appetite
• lower back or side pain
• nausea or vomiting
• nosebleeds
• not breathing
• painful or difficult urination
• pale or blue lips, fingernails, or skin
• pinpoint red spots on the skin
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• severe or continuing stomach pain
• skin rash, hives, or itching
• sore throat
• sore tongue
• sores, ulcers, or white spots on the lips or in the mouth
• tightness in the chest
• unable to speak
• unusual bleeding or bruising
• unusual tiredness or weakness
• upper right abdominal or stomach pain
• yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking acetaminophen / hydrocodone:

• Bloody or cloudy urine
• change in consciousness
• chest pain or discomfort
• cold and clammy skin
• decreased awareness or responsiveness
• extreme drowsiness
• general feeling of discomfort or illness
• increased sweating
• irregular heartbeat
• lightheadedness, dizziness, or fainting
• loss of consciousness
• no blood pressure or pulse
• no muscle tone or movement
• not breathing
• severe sleepiness
• slow or irregular heartbeat
• stopping of heart
• sudden decrease in the amount of urine
• unconsciousness
• unpleasant breath odor

Some side effects of acetaminophen / hydrocodone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Drowsiness
• relaxed and calm
• sleepiness

• Belching
• changes in mood
• difficulty having a bowel movement (stool)
• fear or nervousness
• feeling of indigestion
• hearing loss
• impaired hearing
• pain in the chest below the breastbone
• unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

For Healthcare Professionals

Applies to acetaminophen / hydrocodone: oral capsule, oral elixir, oral liquid, oral solution, oral tablet

General

The most commonly reported adverse reactions include light-headedness, dizziness, sedation, nausea and vomiting.[Ref]

Nervous system

Hydrocodone-acetaminophen:
Frequency not reported: Dizziness, lightheadedness, mental and physical performance impairment, lethargy, sedation, somnolence progressing to stupor or coma

Opioids:
Frequency not reported: Serotonin syndrome[Ref]

Cases of serotonin syndrome have been reported during concomitant use of opioids with serotonergic drugs.[Ref]

Cardiovascular

Frequency not reported: Bradycardia, cardiac arrest, circulatory collapse, hypotension

Hepatic

Frequency not reported: Hepatic necrosis, hepatitis[Ref]

Gastrointestinal

Frequency not reported: Abdominal pain, constipation, gastric distress, heartburn, nausea, peptic ulcer, vomiting, occult blood loss[Ref]

Dermatologic

Frequency not reported: Skin rash, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic reactions, cold and clammy skin, diaphoresis[Ref]

Renal

Frequency not reported: Renal toxicity, renal tubular necrosis[Ref]

Hematologic

Frequency not reported: Agranulocytosis, hemolytic anemia, iron deficiency anemia, prolonged bleeding time, thrombocytopenia[Ref]

Hypersensitivity

Frequency not reported: Allergic reactions, anaphylaxis[Ref]

Respiratory

Frequency not reported: Acute airway obstruction, apnea, dose-related respiratory depression, shortness of breath[Ref]

Metabolic

Frequency not reported: Hypoglycemic coma

Genitourinary

Frequency not reported: Ureteral spasm, spasm of vesicle sphincters, urinary retention[Ref]

Endocrine

Opioids:
Frequency not reported: Androgen deficiency, adrenal insufficiency

Other

Frequency not reported: Hearing impairment or permanent loss[Ref]

Cases of hearing impairment or permanent loss have been reported predominantly in patients with chronic overdose.[Ref]

Musculoskeletal

Frequency not reported: Skeletal muscle flaccidity

Psychiatric

Frequency not reported: Anxiety, euphoria, fear, mood changes, psychological dependence, dysphoria

Applies to acetaminophen / hydrocodone: oral capsule, oral elixir, oral liquid, oral solution, oral tablet

General

The most commonly reported adverse reactions include light-headedness, dizziness, sedation, nausea and vomiting.[Ref]

Nervous system

Hydrocodone-acetaminophen:
Frequency not reported: Dizziness, lightheadedness, mental and physical performance impairment, lethargy, sedation, somnolence progressing to stupor or coma

Opioids:
Frequency not reported: Serotonin syndrome[Ref]

Cases of serotonin syndrome have been reported during concomitant use of opioids with serotonergic drugs.[Ref]

Cardiovascular

Frequency not reported: Bradycardia, cardiac arrest, circulatory collapse, hypotension

Hepatic

Frequency not reported: Hepatic necrosis, hepatitis[Ref]

Gastrointestinal

Frequency not reported: Abdominal pain, constipation, gastric distress, heartburn, nausea, peptic ulcer, vomiting, occult blood loss[Ref]

Dermatologic

Frequency not reported: Skin rash, pruritus, Stevens-Johnson syndrome, toxic epidermal necrolysis, allergic reactions, cold and clammy skin, diaphoresis[Ref]

Renal

Frequency not reported: Renal toxicity, renal tubular necrosis[Ref]

Hematologic

Frequency not reported: Agranulocytosis, hemolytic anemia, iron deficiency anemia, prolonged bleeding time, thrombocytopenia[Ref]

Hypersensitivity

Frequency not reported: Allergic reactions, anaphylaxis[Ref]

Respiratory

Frequency not reported: Acute airway obstruction, apnea, dose-related respiratory depression, shortness of breath[Ref]

Metabolic

Frequency not reported: Hypoglycemic coma

Genitourinary

Frequency not reported: Ureteral spasm, spasm of vesicle sphincters, urinary retention[Ref]

Endocrine

Opioids:
Frequency not reported: Androgen deficiency, adrenal insufficiency

Other

Frequency not reported: Hearing impairment or permanent loss[Ref]

Cases of hearing impairment or permanent loss have been reported predominantly in patients with chronic overdose.[Ref]

Musculoskeletal

Frequency not reported: Skeletal muscle flaccidity

Psychiatric

Frequency not reported: Anxiety, euphoria, fear, mood changes, psychological dependence, dysphoria

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer