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Serious side effects can occur including:

• Harm to an unborn baby. If you are pregnant talk to your doctor about the risks associated with taking minocycline during pregnancy.
• Permanent teeth discoloration. Minocycline may permanently turn a baby or child's teeth yellow-grey-brown during tooth development. Minocycline should not be used during tooth development. Tooth development happens in the last half of pregnancy, and from birth to 8 years of age. 
• Intestine infection (pseudomembranous colitis). Pseudomembranous colitis can happen with most antibiotics, including minocycline. Call your doctor right away if you get watery diarrhea, diarrhea that does not go away, or bloody stools.
• Serious liver problems. Stop taking minocycline and call your doctor right away if you get any of the following symptoms of liver problems:
  • loss of appetite
  • tiredness
  • diarrhea
  • yellowing of your skin or the whites of your eyes
  • unexplained bleeding
  • confusion
  • sleepiness
• Central nervous system effects. Central nervous system effects such as light headedness, dizziness, and a spinning feeling (vertigo) may go away during your treatment with minocycline or if treatment is stopped.
• Benign intracranial hypertension, also called pseudotumor cerebri. This is a condition where there is high pressure in the fluid around the brain. This swelling may lead to vision changes and permanent vision loss. Stop taking minocycline and tell your doctor right away if you have blurred vision, vision loss, or unusual headaches.
• Immune system reactions including a lupus-like syndrome, hepatitis, and inflammation of blood or lymph vessels (vasculitis). Using minocycline for a long time to treat acne may cause immune system reactions. Tell your doctor right away if you get a fever, rash, joint pain, or body weakness. Your doctor may do tests to check your blood for immune system reactions.
• Serious rash and allergic reactions. Minocycline may cause a serious rash and allergic reactions that may affect parts of your body such as your liver, lungs, kidneys and heart. Sometimes these can lead to death. Stop taking minocycline and get medical help right away if you have any of these symptoms:
  • skin rash, hives, sores in your mouth, or your skin blisters and peels
  • swelling of your face, eyes, lips, tongue, or throat
  • trouble swallowing or breathing

Do not take minocycline if you are allergic to tetracycline-class drugs. Ask your doctor or pharmacist for a list of these medicines if you are not sure.

• Avoid sunlight, sunlamps, and tanning beds. Minocycline can make your skin sensitive to the sun and the light from sunlamps and tanning beds. You could get severe sunburn.
• Protect your skin while out in sunlight.
• You should not drive or operate dangerous machinery until you know how this medication affects you. Minocycline may cause you to feel dizzy or lightheaded, or have a spinning feeling (vertigo).