Urelle

Name: Urelle

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What is urelle (hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate)?

Hyoscyamine produces many effects in the body, including relief from muscle spasms.

Methenamine and methylene blue work as mild antiseptics that fight bacteria in the urine and bladder.

Phenyl salicylate is a mild pain reliever.

Sodium biphosphate is a form of phosphorus, which is a naturally occurring substance that is important in every cell in the body.

Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate is a combination medicine used to treat bladder irritation (pain, spasms, inflammation) caused by urinary tract infection. This medicine is also used to prevent bladder discomfort during a medical procedure.

Hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate may also be used for purposes not listed in this medication guide.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking this medicine?

Avoid taking an antacid or anti-diarrhea medicine within 1 hour before or after you take hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium biphosphate. Antacids or anti-diarrhea medicine can make it harder for your body to absorb hyoscyamine.

If you also take ketoconazole (Nizoral), wait at least 2 hours after taking it before you take hyoscyamine, methenamine, methylene blue, phenyl salicylate, and sodium biphosphate.

What other drugs will affect this medicine?

Many drugs can interact with methylene blue. Tell your doctor about all other medications you use. You may need to stop using certain medicines (in some cases for up to 5 weeks before you start treatment with hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate). However, do not stop taking any of your medications without your doctor's advice. This includes:

any type of antidepressant;
diet pills, stimulants, cold or allergy medicines, ADHD medication;
narcotic pain medicine;
medication to treat Parkinson's disease or restless leg syndrome; or
a "triptan" migraine headache medication.

Taking any of the above medications while you are treated with medicine that contains methylene blue can cause high levels of serotonin in the body. Call your doctor right away if you have symptoms of this condition: agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, or fainting.

Many drugs can interact with this medicine. Not all possible interactions are listed here. Also, hyoscyamine can make it harder for your body to absorb other medications you take by mouth. Tell your doctor about all your medications and any you start or stop using, especially:

a diuretic or "water pill";
medicines that change the acidity of your urine--sodium bicarbonate, potassium citrate, sodium citrate with citric acid or potassium;
bladder or urinary medicines--darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin; or
a sulfa drug.

This list is not complete and many other drugs can interact with hyoscyamine, methenamine, methylene blue, phenyl salicylate, sodium biphosphate. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Give a list of all your medicines to any healthcare provider who treats you.

Before Using Urelle

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies performed to date have not demonstrated pediatric-specific problems that would limit the usefulness of Urelle® in children. However, use is not recommended in children 6 years of age and younger.

Geriatric

No information is available on the relationship of age to the effects of Urelle® in geriatric patients.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Acetazolamide
Amifampridine
Amisulpride
Amitriptyline
Amoxapine
Amphetamine
Benzphetamine
Bepridil
Bupropion
Carbamazepine
Carbidopa
Carbinoxamine
Cisapride
Citalopram
Clomipramine
Codeine
Cyclobenzaprine
Desipramine
Desvenlafaxine
Deutetrabenazine
Dextroamphetamine
Doxepin
Doxylamine
Dronedarone
Duloxetine
Entacapone
Escitalopram
Fluoxetine
Fluvoxamine
Hydroxytryptophan
Imipramine
Isocarboxazid
Levodopa
Levomilnacipran
Linezolid
Lisdexamfetamine
Mafenide
Maprotiline
Meperidine
Mesoridazine
Methamphetamine
Milnacipran
Mirtazapine
Nortriptyline
Opicapone
Paroxetine
Phenelzine
Phentermine
Pimozide
Piperaquine
Potassium
Protriptyline
Pseudoephedrine
Rizatriptan
Safinamide
Saquinavir
Selegiline
Sertraline
Silver Sulfadiazine
Sparfloxacin
Sulfabenzamide
Sulfacetamide
Sulfacytine
Sulfadiazine
Sulfamerazine
Sulfamethazine
Sulfamethoxazole
Sulfanilamide
Sulfapyridine
Sulfasalazine
Sulfathiazole
Sulfisoxazole
Sumatriptan
Tapentadol
Terfenadine
Thioridazine
Tramadol
Tranylcypromine
Trazodone
Trimipramine
Tryptophan
Venlafaxine
Vilazodone
Vortioxetine
Ziprasidone
Zolmitriptan
Zonisamide

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac
Acemetacin
Alfentanil
Alfuzosin
Almotriptan
Amineptine
Amiodarone
Amitriptyline
Amitriptylinoxide
Amoxapine
Amtolmetin Guacil
Anagrelide
Apomorphine
Aripiprazole
Aripiprazole Lauroxil
Arsenic Trioxide
Asenapine
Astemizole
Atropine
Azithromycin
Bedaquiline
Bromazepam
Bromfenac
Brompheniramine
Bufexamac
Buprenorphine
Bupropion
Buserelin
Buspirone
Butorphanol
Celecoxib
Chloroquine
Chlorpheniramine
Chlorpromazine
Ciprofloxacin
Citalopram
Clarithromycin
Clomipramine
Clonixin
Clozapine
Cocaine
Crizotinib
Dabrafenib
Dasatinib
Degarelix
Delamanid
Desipramine
Deslorelin
Deutetrabenazine
Dexibuprofen
Dexketoprofen
Dextromethorphan
Dibenzepin
Diclofenac
Difenoxin
Dihydrocodeine
Diphenoxylate
Dipyrone
Disopyramide
Dofetilide
Dolasetron
Domperidone
Donepezil
Droperidol
Droxicam
Efavirenz
Eletriptan
Erythromycin
Escitalopram
Etodolac
Etofenamate
Etoricoxib
Felbinac
Fenoprofen
Fentanyl
Fepradinol
Feprazone
Fingolimod
Flecainide
Flibanserin
Floctafenine
Fluconazole
Flufenamic Acid
Fluoxetine
Flurbiprofen
Foscarnet
Frovatriptan
Furazolidone
Gatifloxacin
Gemifloxacin
Gonadorelin
Goserelin
Granisetron
Halofantrine
Haloperidol
Histrelin
Hydrocodone
Hydromorphone
Hydroxychloroquine
Hydroxyzine
Ibuprofen
Ibutilide
Iloperidone
Imipramine
Indomethacin
Iobenguane I 123
Iproniazid
Ivabradine
Ketoconazole
Ketoprofen
Lapatinib
Leuprolide
Levofloxacin
Levorphanol
Lithium
Lofepramine
Lopinavir
Lorcaserin
Lornoxicam
Loxoprofen
Lumefantrine
Lumiracoxib
Meclofenamate
Mefenamic Acid
Mefloquine
Melitracen
Meloxicam
Methadone
Metronidazole
Midodrine
Mifepristone
Moclobemide
Morniflumate
Morphine
Morphine Sulfate Liposome
Moxifloxacin
Nabumetone
Nafarelin
Nalbuphine
Naproxen
Naratriptan
Nefazodone
Nepafenac
Nialamide
Niflumic Acid
Nilotinib
Nimesulide
Nimesulide Beta Cyclodextrin
Norfloxacin
Nortriptyline
Octreotide
Ofloxacin
Ondansetron
Opipramol
Oxaprozin
Oxycodone
Oxymetazoline
Oxymorphone
Oxyphenbutazone
Paliperidone
Palonosetron
Panobinostat
Parecoxib
Pasireotide
Pazopanib
Pentazocine
Periciazine
Phenylbutazone
Piketoprofen
Pimavanserin
Piroxicam
Pitolisant
Posaconazole
Procainamide
Procarbazine
Prochlorperazine
Proglumetacin
Promethazine
Propafenone
Propyphenazone
Proquazone
Protriptyline
Quetiapine
Quinidine
Quinine
Ranolazine
Rasagiline
Remifentanil
Ribociclib
Rofecoxib
Salmeterol
Sevoflurane
Sibutramine
Solifenacin
Sorafenib
Sotalol
St John's Wort
Sufentanil
Sulindac
Sulpiride
Sunitinib
Tacrolimus
Telavancin
Telithromycin
Tenoxicam
Tetrabenazine
Tianeptine
Tiaprofenic Acid
Tiotropium
Tizanidine
Tolfenamic Acid
Tolmetin
Trazodone
Trimipramine
Triptorelin
Valbenazine
Valdecoxib
Vandetanib
Vardenafil
Vemurafenib
Vinflunine
Voriconazole
Ziprasidone
Zuclopenthixol

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acarbose
Aluminum Carbonate, Basic
Aluminum Hydroxide
Aluminum Phosphate
Calcium Acetate
Calcium Carbonate
Calcium Citrate
Chlorpropamide
Dihydroxyaluminum Aminoacetate
Dihydroxyaluminum Sodium Carbonate
Glimepiride
Glipizide
Glyburide
Insulin
Insulin Aspart, Recombinant
Insulin Bovine
Insulin Degludec
Insulin Detemir
Insulin Glargine, Recombinant
Insulin Glulisine
Insulin Lispro, Recombinant
Magaldrate
Magnesium Carbonate
Magnesium Hydroxide
Magnesium Oxide
Magnesium Trisilicate
Metformin
Nateglinide
Repaglinide
Tolazamide
Tolbutamide

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Uses of Urelle

It is used to ease pain from a bladder infection.
It is used to treat muscle spasms of the urinary system.
It is used to treat urinary signs.
It may be given to you for other reasons. Talk with the doctor.

If OVERDOSE is suspected

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

How do I store and/or throw out Urelle?

Store at room temperature.
Protect from light.
Store in a dry place. Do not store in a bathroom.
Keep lid tightly closed.
Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
Check with your pharmacist about how to throw out unused drugs.

Consumer Information Use and Disclaimer

If your symptoms or health problems do not get better or if they become worse, call your doctor.
Do not share your drugs with others and do not take anyone else's drugs.
Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take Urelle or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to Urelle. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: October 4, 2017

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
A fast heartbeat.
Blurred eyesight.
Dizziness.
Shortness of breath.
Trouble passing urine.