Travatan

Apply this medication in the affected eye(s) usually once a day in the evening, or as directed by your doctor. Do not use travoprost more often because it will not work as well.To apply eye drops, wash your hands first. To avoid contamination, do not touch the dropper tip or let it touch your eye or any other surface.Remove contact lenses before using this medication if your brand contains the preservative benzalkonium chloride. This preservative can be absorbed by contact lenses. Wait at least 15 minutes after using this medication before putting your lenses back in.Tilt your head back, look upward and pull down the lower eyelid to make a pouch. Hold the dropper directly over your eye and place one drop into the pouch. Look downward and gently close your eyes for 1 to 2 minutes. Place one finger at the corner of your eye (near the nose) and apply gentle pressure. This will prevent the medication from draining out. Try not to blink and do not rub your eye. Repeat these steps for your other eye if so directed.Do not rinse the dropper. Replace the dropper cap after each use.If you are using another kind of eye medication (e.g., drops or ointments), wait at least 5 minutes before applying other medications. Use eye drops before eye ointments to allow the eye drops to enter the eye.Use this medication regularly in order to get the most benefit from it. Remember to use it at the same time each day. It is important to continue using travoprost even if you feel well. Most people with glaucoma or high pressure in the eye do not have symptoms.

Travoprost ophthalmic (for the eye) reduces pressure in the eye by increasing the amount of fluid that drains from the eye.

Travoprost ophthalmic is used to treat certain types of glaucoma and other causes of high pressure inside the eye.

Travoprost ophthalmic may also be used for other purposes not listed in this medication guide.

Travoprost ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

Do not allow the dropper to touch any surface, including the eyes or hands. If the dropper becomes contaminated it could cause an infection in your eye, which can lead to vision loss or serious damage to the eye.

After using this medication, wait at least 5 minutes before using any other eye drops that your doctor has prescribed.

Do not use this medication if you are allergic to travoprost.

Before using travoprost, tell your doctor if you are allergic to any drugs, or if you have swelling or infection of your eye.

Travoprost ophthalmic may cause a gradual change in the color of your eyes or eyelids and lashes, as well as increased growth or thickness of your eyelashes. These color changes, usually an increase in brown pigment, occur slowly and you may not notice them for months or years. Color changes may be permanent even after your treatment ends, and may occur only in the eye being treated. This could result in a cosmetic difference in eye or eyelash color from one eye to the other.

FDA pregnancy category C. It is not known whether travoprost is harmful to an unborn baby. Before using this medication, tell your doctor if you are pregnant or plan to become pregnant during treatment.

It is not known whether travoprost passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop using travoprost ophthalmic and call your doctor at once if you have any of these serious side effects:

• redness, swelling, itching, or pain in or around your eye;
• oozing or discharge from your eye;
• increased sensitivity to light;
• vision changes; or
• chest pain.

Less serious side effects may include:

• mild eye discomfort;
• headache;
• feeling like something is in your eye;
• blurred vision;
• dry or watery eyes; or
• stinging or burning of the eyes after using the drops.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

• Selective prostanoid agonist;1 mimics the effects of PGF2α at its prostanoid receptor.7

• Appears to reduce IOP by increasing uveoscleral outflow of aqueous humor.1

Your eye doctor will want to examine your eyes at regular visits to make sure that this medicine is working properly and is not causing unwanted effects.

This medicine may cause the iris (colored part), eyelid, or eyelashes of your treated eye to turn brown. Your eyelashes may also become longer, thicker, and darker. Some of these changes may be permanent even if you stop using travoprost. Check with your doctor if you have any questions about this.

Check with your doctor right away if you have an eye injury, eye infection, or plan to have eye surgery.

None

Travoprost is a synthetic prostaglandin F analogue. Its chemical name is [1R-[1α(Z),2β(1E,3R*),3α,5α]]-7-[3,5-Dihydroxy-2-[3-hydroxy-4-[3-(trifluoromethyl) phenoxy]-1-butenyl]cyclopentyl]-5-heptenoic acid, 1-methylethylester. It has a molecular formula of C26H35F3O6 and a molecular weight of 500.55. The chemical structure of travoprost is:

Travoprost is a clear, colorless to slightly yellow oil that is very soluble in acetonitrile, methanol, octanol, and chloroform. It is practically insoluble in water.

Travatan Z® (travoprost ophthalmic solution) 0.004% is supplied as sterile, buffered aqueous solution of travoprost with a pH of approximately 5.7 and an osmolality of approximately 290 mOsmol/kg.

Travatan Z® contains Active: travoprost 0.04 mg/mL; Inactives: polyoxyl 40 hydrogenated castor oil, sofZia® (boric acid, propylene glycol, sorbitol, zinc chloride), sodium hydroxide and/or hydrochloric acid (to adjust pH) and purified water, USP. Preserved in the bottle with an ionic buffered system, sofZia®.

Avoid using too much Travatan, which can actually make it less effective in lowering the pressure inside the eye.

Avoid using any eyedrop medicine that has not been prescribed by your doctor.

Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using Travatan and call your doctor at once if you have any of these serious side effects:

• redness, swelling, itching, or pain in or around your eye;

• oozing or discharge from your eye; or

• increased sensitivity to light;

• vision changes.

• chest pain.

Less serious Travatan side effects may include:

• mild eye discomfort;

• headache;

• feeling like something is in your eye;

• blurred vision;

• dry or watery eyes; or

• stinging or burning of the eyes after using the drops.

This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.

Applies to travoprost ophthalmic: ophthalmic solution

Along with its needed effects, travoprost ophthalmic (the active ingredient contained in Travatan) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking travoprost ophthalmic:

More common

• Eye pain
• itching eye
• redness of the eye
• redness, swelling, or itching of eyelid

Less common

• Blurred or decreased vision
• burning, dry, or itching eyes
• eye color changes
• redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

Some side effects of travoprost ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

• Eye discomfort
• feeling of having something in the eye

Less common

• Acid or sour stomach (heartburn or indigestion)
• blood in the urine
• chest pain or tightness
• dry eyes
• eye discharge or excessive tearing
• faintness or lightheadedness when getting up from a lying or sitting position
• loss of bladder control
• lower back pain
• muscle pain or stiffness
• pain, swelling, or redness in the joints
• pain or burning while urinating
• pelvic pain
• slow or irregular heartbeat (less than 50 beats per minute)

It is not likely that other drugs you take orally or inject will have an effect on travoprost used in the eyes. But many drugs can interact with each other. Tell each of your healthcare providers about all medicines you use, including prescription and over-the-counter medicines, vitamins, and herbal products.