Trabectedin Intravenous

Trabectedin injection is used to treat certain types of cancer, including liposarcoma or leiomyosarcoma that cannot be treated with surgery or has spread to other parts of the body. It is used in patients who have received treatment with other medicines.

trabectedin is to be given only by or under the supervision of your doctor.

Your doctor will check your progress closely while you are receiving trabectedin. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to receive it. Blood tests may be needed to check for unwanted effects.

Using trabectedin while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant during treatment and for at least 2 months after your last dose. Men receiving trabectedin should use condoms or other birth control forms during treatment and for at least 5 months after your final dose. If you think you have become pregnant while using trabectedin, tell your doctor right away.

trabectedin may cause serious allergic reactions, including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving trabectedin.

Check with your doctor if you notice any signs of fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cell counts.

Rhabdomyolysis may occur while receiving trabectedin. Tell your doctor if you have severe muscle, bone, or joint pain after receiving trabectedin.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. These could be symptoms of a serious liver problem.

Call your doctor right away if you have chest pain, trouble breathing, swelling in your ankles or feet, or fast or irregular heartbeat. These maybe symptoms of cardiomyopathy.

Tell your doctor right away if you have redness, swelling, or pain at the injection site after receiving trabectedin.

Do not eat grapefruit or drink grapefruit juice while you are using trabectedin.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Trabectedin is used to treat certain types of cancer. It is a chemotherapy drug that works by slowing the growth of cancer cells.

How to use Trabectedin Solution, Reconstituted (Recon Soln)

Read the Patient Information Leaflet if available from your pharmacist before you start using trabectedin and before each treatment. If you have any questions, ask your doctor or pharmacist.

This medication is given by injection into a large vein (central line) by a health care professional. It is usually given every 3 weeks.

Your doctor will order a corticosteroid (such as dexamethasone) to lower the risk of liver problems or prevent side effects such as nausea/vomiting. These medications are usually given at least 30 minutes before your dose of trabectedin.

The dosage is based on your height, weight, medical condition, lab test results, and response to treatment.

Before receiving trabectedin, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain other inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: low blood cell counts, liver disease (such as active hepatitis), kidney disease, recent/current infections.

This drug may make you feel tired or weak. Alcohol or marijuana can make you more tired. Do not drive, use machinery, or do anything that needs alertness until you can do it safely. Avoid alcoholic beverages. Alcohol can increase the risk of liver problems. Talk to your doctor if you are using marijuana. .

Trabectedin can make you more likely to get infections or may worsen any current infections. Therefore, wash your hands well to prevent the spread of infection. Avoid contact with people who have infections that may spread to others (such as chickenpox, measles, flu). Consult your doctor if you have been exposed to an infection or for more details.

Do not have immunizations/vaccinations without the consent of your doctor. Avoid contact with people who have recently received live vaccines (such as flu vaccine inhaled through the nose).

To lower the chance of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

This medication may damage sperm in men. For both men and women using this medication, trabectedin may decrease the ability to have children in the future. Consult your doctor for more details.

This medication must not be used during pregnancy. It may harm an unborn baby. If you become pregnant or think you may be pregnant, or if your partner becomes pregnant, tell your doctor right away. To avoid pregnancy, both men and women receiving this drug should use reliable form(s) of birth control (such as birth control pills, condoms) during treatment, and for 3 months after treatment for women, and for 5 months after treatment for men. Consult your doctor for details and to discuss effective forms of birth control.

It is unknown if this drug passes into breast milk. Do not breast-feed while using this drug and for 3 months after treatment.

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Some products that may interact with this drug include: "statins" (such as atorvastatin, simvastatin).

Other medications can affect the removal of trabectedin from your body, thereby affecting how trabectedin works. These drugs include azole antifungals (such as fluconazole, ketoconazole), macrolide antibiotics (such as clarithromycin), HIV drugs (such as ritonavir), rifamycins (such as rifabutin), St. John's wort, and some drugs used to treat seizures (such as carbamazepine, phenobarbital, primidone), among others.

If someone has overdosed and has serious symptoms such as passing out or trouble breathing, call 911. Otherwise, call a poison control center right away. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Lab and/or medical tests (such as complete blood count, kidney/liver/heart function) must be done before and while you are using this medication. Keep all medical and lab appointments.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule.

Storage

Not applicable. This medication is given in a hospital and will not be stored at home.Information last revised July 2017. Copyright(c) 2017 First Databank, Inc.