Tenofovir

• Viread^®

Before you start treatment with tenofovir, your doctor may perform tests to make sure you do not have HIV (if you are being treated for hepatitis B) or hepatitis B (if you are being treated for HIV).

Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.

Tenofovir tablets may be taken with or without food.

Tenofovir oral powder should be taken with food. Mix the powder with soft food such as applesauce, yogurt, or baby food. Do not mix tenofovir oral powder with liquid.

If a child is taking this medication, tell your doctor if the child has any changes in weight. Tenofovir doses are based on weight in children.

This medication comes with patient instructions for safe and effective use. Follow these directions carefully. Ask your doctor or pharmacist if you have any questions.

While using tenofovir, you may need frequent blood tests. Your liver and kidney function may also need to be checked.

Use tenofovir regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.

HIV/AIDS is usually treated with a combination of drugs. Use all medications as directed by your doctor. Read the medication guide or patient instructions provided with each medication. Do not change your doses or medication schedule without your doctor's advice. Every person with HIV or AIDS should remain under the care of a doctor.

Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.

If you have hepatitis B you may develop liver symptoms after you stop taking this medication, even months after stopping. Your doctor may want to check your liver function for several months after you stop using tenofovir. Visit your doctor regularly.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Medicines can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of tenofovir, there are no specific foods that you must exclude from your diet when receiving tenofovir.

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

This medication falls into category B. It is not known if tenofovir will harm your unborn baby. There is a pregnancy registry for women who take antiviral medicines during pregnancy. Its purpose is to collect information about the health of you and your baby. Talk to your healthcare provider about how you can take part in this registry.

• Take tenofovir exactly as your healthcare provider tells you to take it.
• Take tenofovir at the same time every day.
• For adults: the usual dose of tenofovir is one 300 mg tablet each day. If you have kidney problems, your healthcare provider may tell you to take tenofovir less often.
• Adults who are unable to swallow tenofovir tablets whole may take 7½ scoops of tenofovir oral powder.
• For children 2 years of age and older, your healthcare provider will prescribe the right dose of tenofovir oral powder or tablets based on your child's body weight.
• Tell your healthcare provider if your child has problems with swallowing tablets.
• Take tenofovir tablets by mouth, with or without food.
• Do not miss a dose of tenofovir. If you miss a dose of tenofovir, take the missed dose as soon as you remember. If it is almost time for your next dose of tenofovir, do not take the missed dose. Take the next dose of tenofovir at your regular time.
• If you take too much tenofovir, call your local poison control center or go right away to the nearest hospital emergency room.

Preparation of tenofovir powder:

1. Wash and dry your hands.
2. Measure ¼ to ½ cup of soft food into a cup or bowl.
3. To open a new bottle of powder, press down on the bottle lid and turn to remove (see picture on the top of the bottle cap). Peel off the foil.
4. Measure the number of scoops prescribed by your healthcare provider.
   • For each full scoop prescribed:
     • Fill the dosing scoop to the top.
     • Use the flat edge of clean knife to make the powder even with the top of the scoop 
   • For ½ scoop:
     • Fill the dosing scoop up to the "½ line" on the side
5. Sprinkle the tenofovir oral powder on the soft food. Stir with a spoon until well mixed. Give the entire dose right away after mixing to avoid a bad taste.
6. Close the bottle of tenofovir tightly.
7. Wash and dry the dosing scoop. Do not store the dosing scoop in the bottle.

Tenofovir is an antiviral medicine that prevents human immunodeficiency virus (HIV) or hepatitis B from multiplying in your body.

Tenofovir is used to treat HIV, the virus that can cause acquired immunodeficiency syndrome (AIDS). Tenofovir is not a cure for HIV or AIDS.

Tenofovir is also used to treat chronic hepatitis B.

Tenofovir may also be used for purposes not listed in this medication guide.

Tenofovir is used in combination with other medicines for the treatment of the infection caused by the human immunodeficiency virus (HIV). HIV is the virus that causes acquired immunodeficiency syndrome (AIDS).

Tenofovir will not cure or prevent HIV infection or AIDS. It helps keep HIV from reproducing and appears to slow down the destruction of the immune system. This may help delay problems that are usually related to AIDS or HIV disease from occurring. Tenofovir will not keep you from spreading HIV to other people. People who receive tenofovir may continue to have some of the problems usually related to AIDS or HIV disease.

Tenofovir is also used to treat chronic (long-term) hepatitis B virus (HBV) infection.

tenofovir is available only with your doctor's prescription.

300 mg orally once a day

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

2 to less than 12 years: 8 mg/kg orally once a day
Maximum dose: 300 mg/dose

12 years or older and at least 35 kg: 300 mg orally once a day

Dose based on body weight for pediatric patients 2 years or older:
Oral powder:
10 to less than 12 kg: 80 mg (2 scoops of powder) orally once a day
12 to less than 14 kg: 100 mg (2.5 scoops of powder) orally once a day
14 to less than 17 kg: 120 mg (3 scoops of powder) orally once a day
17 to less than 19 kg: 140 mg (3.5 scoops of powder) orally once a day
19 to less than 22 kg: 160 mg (4 scoops of powder) orally once a day
22 to less than 24 kg: 180 mg (4.5 scoops of powder) orally once a day
24 to less than 27 kg: 200 mg (5 scoops of powder) orally once a day
27 to less than 29 kg: 220 mg (5.5 scoops of powder) orally once a day
29 to less than 32 kg: 240 mg (6 scoops of powder) orally once a day
32 to less than 34 kg: 260 mg (6.5 scoops of powder) orally once a day
34 to less than 35 kg: 280 mg (7 scoops of powder) orally once a day
At least 35 kg: 300 mg (7.5 scoops of powder) orally once a day

Tablets:
17 to less than 22 kg: 150 mg orally once a day
22 to less than 28 kg: 200 mg orally once a day
28 to less than 35 kg: 250 mg orally once a day
At least 35 kg: 300 mg orally once a day

Comments:
-Weight should be monitored periodically and the dose should be adjusted accordingly.

Use: In combination with other antiretroviral agents, for the treatment of HIV-1 infection

US CDC recommendations:
2 years or older:
Oral powder: 8 mg/kg orally once a day
Maximum dose: 300 mg/dose

Tablets:
17 to less than 22 kg: 150 mg orally once a day
22 to less than 28 kg: 200 mg orally once a day
28 to less than 35 kg: 250 mg orally once a day
At least 35 kg: 300 mg orally once a day

Duration of therapy: 28 days

Comments:
-This drug is recommended as a component of a preferred (or alternative) 3-drug regimen for nonoccupational postexposure prophylaxis of HIV infection in children (aged 2 to 12 years).
-This drug and emtricitabine (as emtricitabine-tenofovir DF) plus (raltegravir or dolutegravir) is recommended as the preferred regimen for nonoccupational postexposure prophylaxis of HIV infection in adolescents (13 years or older) with CrCl at least 60 mL/min; this drug and emtricitabine (as emtricitabine-tenofovir DF) plus darunavir/ritonavir is recommended as an alternative regimen for such patients.
-If other alternatives are considered, this drug is recommended as a component in various regimens.
-Prophylaxis should be started as soon as possible, within 72 hours of exposure.
-Current guidelines should be consulted for additional information.

No adjustment recommended.