Tarabine PFS

Tarabine PFS is part of the drug class:

• Pyrimidine analogues

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

• gentamicin (Gentak, Genoptic)
• digoxin (Lanoxin)
• flucytosine (Ancobon)

This is not a complete list of cytarabine drug interactions. Ask your doctor or pharmacist for more information.

LIPISOME INJECTION FORMULATION:

This medication should be administered only under the supervision of a qualified physician experienced in the use of intrathecal cancer chemotherapeutic agents. Appropriate management of complications is possible only when adequate diagnostic and treatment facilities are readily available. In all clinical studies, chemical arachnoiditis, a syndrome manifested primarily by nausea, vomiting, headache, and fever was a common adverse event. If left untreated, chemical arachnoiditis may be fatal. The incidence and severity of chemical arachnoiditis can be reduced by coadministration of dexamethasone. Patients receiving this medication should be treated concurrently with dexamethasone to mitigate the symptoms of chemical arachnoiditis.

INJECTABLE FORMULATION:

Only physicians experienced in cancer chemotherapy should use cytarabine Injection.

For induction therapy patients should be treated in a facility with laboratory and supportive resources sufficient to monitor drug tolerance and protect and maintain a patient compromised by drug toxicity. The main toxic effect of cytarabine is bone marrow suppression with leukopenia, thrombocytopenia and anemia.

Less serious toxicity includes nausea, vomiting, diarrhea and abdominal pain, oral ulceration and hepatic dysfunction.

The physician must judge possible benefit to the patient against known toxic effects of this drug in considering the advisability of therapy with cytarabine. Before making this judgment or beginning treatment, the physician should be familiar with the following text.