Royal jelly

Name: Royal jelly

What Is Royal Jelly?

Royal jelly is a milky-white secretion produced by worker bees that helps nurture development of the queen bee. Royal jelly is also known as Apis mellifera, Bee Saliva, Bee Spit, Gelée Royale, Honey Bee Milk, Honey Bee's Milk, Jalea Real, Lait des Abeilles, or Royal Bee Jelly.

Royal jelly should not be confused with apitherapy, bee pollen, or bee venom.

Royal jelly has been used in alternative medicine as a possibly effective aid in treating menopausal symptoms. Royal jelly may have been combined with other plants or extracts in a specific preparation to treat this condition.

Royal jelly has also been used to treat hay fever. However, research has shown that royal jelly may not be effective in treating this condition.

Other uses not proven with research have included treating premenstrual syndrome, infertility, high cholesterol, diabetic foot ulcers, stomach ulcer, pancreatitis, liver or kidney disease, asthma, skin disorders, and many other conditions.

It is not certain whether royal jelly is effective in treating any medical condition. Medicinal use of this product has not been approved by the FDA. Royal jelly should not be used in place of medication prescribed for you by your doctor.

Royal jelly is often sold as an herbal supplement. There are no regulated manufacturing standards in place for many herbal compounds and some marketed supplements have been found to be contaminated with toxic metals or other drugs. Herbal/health supplements should be purchased from a reliable source to minimize the risk of contamination.

Royal jelly may also be used for purposes not listed in this product guide.

Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

You should not use this product if you are allergic to royal jelly or if you have:

  • asthma or allergies.

Ask a doctor, pharmacist, or other healthcare provider if it is safe for you to use this product if you have:

  • low blood pressure; or
  • skin irritation or swelling.

It is not known whether royal jelly will harm an unborn baby. Do not use this product without medical advice if you are pregnant.

It is not known whether royal jelly passes into breast milk or if it could harm a nursing baby. Do not use this product without medical advice if you are breast-feeding a baby.

Royal jelly is thought to be possibly safe in children when taken for up to 6 months. Do not give any herbal/health supplement to a child without medical advice.

What is the most important information I should know about royal jelly?

Follow all directions on the product label and package. Tell each of your healthcare providers about all your medical conditions, allergies, and all medicines you use.

Uses

Royal jelly has been studied for a variety of actions, including antimicrobial, antitumor, antihypertensive, and immunoregulatory activity. Additionally, effects on lipid profile, insulin-like action, and neurological and estrogenic effects have been demonstrated. However, clinical trials are lacking.

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking. Royal jelly possesses some estrogenic activity.

Adverse Reactions

In many allergy patients, skin tests were positive for royal jelly. There have been case reports of allergy, acute exacerbation of asthma, anaphylaxis, and death.

Toxicology

Data are limited.

Royal jelly is a milky-white secretion produced by the hypopharyngeal and mandibular glands of worker honeybees of the species A. mellifera L . to induce differentiated growth and development of the queen bee. Royal jelly is the principal food of the honeybee queen. Because of this specialized nutrition, queen bees differ from workers in several ways; the queens are approximately twice the size, they lay approximately 2,000 eggs a day (female worker bees are infertile), and they live 5 to 8 years (approximately 40 times longer than worker bees). 1 These differences have led to the marketable assumption that ingestion of this product will do as much for humans as it does for bees; that is, increase size, improve fertility, and enhance longevity.

History

In many countries, royal jelly has been promoted widely as a commercially available medicine, health food, and cosmetic (as an emollient, moisturizer, and nourishing substance). It is used in traditional medicine for longevity in Europe and Asia. Royal jelly has been sold as a skin tonic and hair growth stimulant. 1 , 2 , 3

Bibliography

1. Tyler VE. The New Honest Herbal: A Sensible Guide to the Use of Herbs and Related Remedies . 2nd ed. Philadelphia, PA: G.F. Stickley Co; 1987.
2. Inoue S, Koya-Miyata S, Ushio S, Iwaki K, Ikeda M, Kurimoto M. Royal jelly prolongs the life span of C3H/HeJ mice: correlation with reduced DNA damage. Exp Gerontol . 2003;38(9):965-969.
3. Viuda-Martos M, Ruiz-Navajas Y, Fernández-López J, Pérez-Alvarez JA. Functional properties of honey, propolis, and royal jelly. J Food Sci . 2008;73(9):R117-R124.
4. Kimura Y, Ushijima T, Maeda M, et al. Tumor antigen occurs in N-glycan of royal jelly glycoproteins: honeybee cells synthesize T-antigen unit in N-glycan moiety. Biosci Biotechnol Biochem . 2006;70(10):2583-2587.
5. Schönleben S, Sickmann A, Mueller MJ, Reinders J. Proteome analysis of Apis mellifera royal jelly. Anal Bioanal Chem . 2007;389(4):1087-1093.
6. Schmitzová J, Klaudiny J, Albert S, et al. A family of major royal jelly proteins of the honeybee Apis mellifera L. Cell Mol Life Sci . 1998;54(9):1020-1030.
7. Bíliková K, Hanes J, Nordhoff E, Saenger W, Klaudiny J, Simúth J. Apisimin, a new serine-valine-rich peptide from honeybee ( Apis mellifera L.) royal jelly: purification and molecular characterization. FEBS Lett . 2002;528(1-3):125-129.
8. Izuta H, Chikaraishi Y, Shimazawa M, Mishimas, Hara H. 10-Hydroxy-2-decenoic acid, a major fatty acid from royal jelly, inhibits VEGF-induced angiogenesis in human umbilical vein endothelial cells. Evid Based Complement Alternat Med . 2009;6(4):489-494.
9. Zhang JZ, Xue XF, Zhou JH, et al. Determination of tryptophan in bee pollen and royal jelly by high-performance liquid chromatography with fluorescence detection. Biomed Chromatogr . 2009;23(9):994-998
10. Salazar-Olivo LA, Paz-González V. Screening of biological activities present in honeybee ( Apis mellifera ) royal jelly. Toxicol In Vitro . 2005;19(5):645-651.
11. Hattori N, Nomoto H, Mishima S, et al. Identification of AMP N1-oxide in royal jelly as a component neurotrophic toward cultured rat pheochromocytoma PC12 cells. Biosci Biotechnol Biochem . 2006;70(4):897-906.
12. Kodai T, Umebayashi K, Nakatani T, Ishiyama K, Noda N. Compositions of royal jelly II. Organic acid glycosides and sterols of the royal jelly of honeybees ( Apis mellifera ). Chem Pharm Bull (Tokyo) . 2007;55(10):1528-1531.
13. Suzuki KM, Isohama Y, Maruyama H, et al. Estrogenic activities of fatty acids and a sterol isolated from royal jelly. Evid Based Complement Alternat Med . 2008;5(3):295-302.
14. Supabphol R. Antibacterial activity of royal jelly royalisin: potent antibacterial protein from royal jelly. Warasan Phesatchasat . 1995;22:33-38.
15. Boukraâ L, Meslem A, Benhanifia M, Hammoudi SM. Synergistic effect of starch and royal jelly against Staphylococcus aureus and Escherichia coli . J Altern Complement Med . 2009;15(7):755-757.
16. Boukraâ L, Niar A, Benbarek H, Benhanifia M. Additive action of royal jelly and honey against Staphylococcus aureus . J Med Food . 2008;11(1):190-192.
17. Jamnik P, Goranovic D, Raspor P. Antioxidative action of royal jelly in the yeast cell. Exp Gerontol . 2007;42(7):594-600.
18. El-Nekeety AA, El-Kholy W, Abbas NF, Ebaid A, Amra HA, Abdel-Wahhab MA. Efficacy of royal jelly against the oxidative stress of fumonisin in rats. Toxicon . 2007;50(2):256-269.
19. Nagai T, Inoue R, Suzuki N, Nagashima T. Antioxidant properties of enzymatic hydrolysates from royal jelly. J Med Food . 2006;9(3):363-367.
20. Liu JR, Yang YC, Shi LS, Peng CC. Antioxidant properties of royal jelly associated with larval age and time of harvest. J Agric Food Chem . 2008;56(23):11447-11452.
21. Silici S, Ekmekcioglu O, Eraslan G, Demirtas A. Antioxidative effect of royal jelly in cisplatin-induced testes damage. Urology . 2009;74(3):545-551.
22. Kanbur M, Eraslan G, Silici S, Karabacak M. Effects of sodium fluoride exposure on some biochemical parameters in mice: evaluation of the ameliorative effect of royal jelly applications on these parameters. Food Chem Toxicol . 2009;47(6):1184-1189.
23. Kanbur M, Eraslan G, Beyaz L, et al. The effects of royal jelly on liver damage induced by paracetamol in mice. Exp Toxicol Pathol . 2009;61(2):123-132.
24. Guo H, Ekusa A, Iwai K, Yonekura M, Takahata Y, Morimatsu F. Royal jelly peptides inhibit lipid peroxidation in vitro and in vivo. J Nutr Sci Vitaminol (Tokyo) . 2008;54(3):191-195.
25. Townsend GF, Morgan JF, Hazlett B. Activity of 10-hydroxydecenoic acid from royal jelly against experimental leukaemia and ascitic tumours. Nature . 1959;183(4670):1270-1271.
26. Nakaya M, Onda H, Sasaki K, Yukiyoshi A, Tachibana H, Yamada K. Effect of royal jelly on bisphenol A-induced proliferation of human breast cancer cells. Biosci Biotechnol Biochem . 2007;71(1):253-255.
27. Mishima S, Suzuki KM, Isohama Y, et al. Royal jelly has estrogenic effects in vitro and in vivo. J Ethnopharmacol . 2005;101(1-3):215-220.
28. Kridli RT, Al-Khetib SS. Reproductive responses in ewes treated with eCG or increasing doses of royal jelly. Anim Reprod Sci . 2006;92(1-2):75-85.
29. Husein MQ, Haddad SG. A new approach to enhance reproductive performance in sheep using royal jelly in comparison with equine chorionic gonadotropin. Anim Reprod Sci . 2006;93(1-2):24-33.
30. Kridli RT, Husein MQ, Humphrey WD. Effect of royal jelly and GnRH on the estrus synchronization and pregnancy rate in ewes using intravaginal sponges. Small Rumin Res . 2003;49(1):25-30.
31. Hidaka S, Okamoto Y, Uchiyama S, et al. Royal jelly prevents osteoporosis in rats: beneficial effects in ovariectomy model and in bone tissue culture model. Evid Based Complement Alternat Med . 2006;3(3):339-348.
32. Matsui T, Yukiyoshi A, Doi S, Sugimoto H, Yamada H, Matsumoto K. Gastrointestinal enzyme production of bioactive peptides from royal jelly protein and their antihypertensive ability in SHR. J Nutr Biochem . 2002;13(2):80-86.
33. Librowski T, Czarnecki R. Comparative analysis of Apistmul Crataegi Forte and royal jelly in the experimental heart action disturbance. Herba Pol . 2000;46(3):145-150.
34. Takaki-Doi S, Hashimoto K, Yamamura M, Kamei C. Antihypertensive activities of royal jelly protein hydrolysate and its fractions in spontaneously hypertensive rats. Acta Med Okayama . 2009;63(1):57-64.
35. Zamami Y, Takatori S, Goda M, et al. Royal jelly ameliorates insulin resistance in fructose-drinking rats. Biol Pharm Bull . 2008;31(11):2103-2107.
36. Okamoto I, Taniguchi Y, Kunikata T, et al. Major royal jelly protein 3 modulates immune responses in vitro and in vivo. Life Sci . 2003;73(16):2029-2045.
37. Taniguchi Y, Kohno K, Inoue S, et al. Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice. Int Immunopharmacol . 2003;3(9):1313-1324.
38. Oka H, Emori Y, Kobayashi N, Hayashi Y, Nomoto K. Suppression of allergic reactions by royal jelly in association with the restoration of macrophage function and the improvement of Th1/Th2 cell responses. Int Immunopharmacol . 2001;1(3):521-532.
39. Vucevic D, Melliou E, Vasilijic S, et al. Fatty acids isolated from royal jelly modulate dendritic cell-mediated immune response in vitro. Int Immunopharmacol . 2007;7(9):1211-1220.
40. Gasic S, Vucevic D, Vasilijic S, Antunovic M, Chinou I, Colic M. Evaluation of the immunomodulatory activities of royal jelly components in vitro. Immunopharmacol Immunotoxicol . 2007;29(3-4):521-536.
41. Bincoletto C, Eberlin S, Figueiredo CA, Luengo MB, Queiroz ML. Effects produced by royal jelly on haematopoiesis: relation with host resistance against Ehrlich ascites tumour challenge. Int Immunopharmacol . 2005;5(4):679-688.
42. Mannoor MK, Shimabukuro I, Tsukamotoa M, Watanabe H, Yamaguchi K, Sato Y. Honeybee royal jelly inhibits autoimmunity in SLE-prone NZB x NZW F1 mice. Lupus . 2009;18(1):44-52.
43. Calli C, Tugyan K, Oncel S, et al. Effectiveness of royal jelly on tympanic membrane perforations: an experimental study. J Otolaryngol Head Neck Surg . 2008;37(2):179-184.
44. Erem C, Deger O, Ovali E, Barlak Y. The effects of royal jelly on autoimmunity in Graves' disease. Endocrine . 2006;30(2):175-183.
45. Münstedt K, Henschel M, Hauenschild A, von Georgi R. Royal jelly increases high density lipoprotein levels but in older patients only. J Altern Complement Med . 2009;15(4):329-330.
46. Guo H, Saiga A, Sato M, et al. Royal jelly supplementation improves lipoprotein metabolism in humans. J Nutr Sci Vitaminol (Tokyo) . 2007;53(4):345-348.
47. Hashimoto M, Kanda M, Ikeno K, et al. Oral administration of royal jelly facilitates mRNA expression of glial cell line-derived neurotrophic factor and neurofilament H in the hippocampus of the adult mouse brain. Biosci Biotechnol Biochem . 2005;69(4):800-805.
48. Hattori N, Ohta S, Sakamoto T, Mishima S, Furukawa S. Royal jelly facilitates restoration of the cognitive ability in trimethyltin-intoxicated mice. [published online ahead of print April 17, 2009] Evid Based Complement Alternat Med . doi:10.1093/ecam/nep029.
49. Hattori N, Nomoto H, Fukumitsu H, Mishima S, Furukawa S. Royal jelly and its unique fatty acid, 10-hydroxy-trans-2-decenoic acid, promote neurogenesis by neural stem/progenitor cells in vitro. Biomed Res . 2007;28(5):261-266.
50. Narita Y, Ohta S, Suzuki KM, Nemoto T, Abe K, Mishima S. Effects of long-term administration of royal jelly on pituitary weight and gene expression in middle-aged female rats. Biosci Biotechnol Biochem . 2009;73(2):431-433.
51. Lee NJ, Fermo JD. Warfarin and royal jelly interaction. Pharmacotherapy . 2006;26(4):583-586.
52. Rosmilah M, Shahnaz M, Patel G, et al. Characterization of major allergens of royal jelly Apis mellifera . Trop Biomed . 2008;25(3):243-251.
53. Testi S, Cecchi L, Severino M, et al. Severe anaphylaxis to royal jelly attributed to cefonicid. J Investig Allergol Clin Immunol . 2007;17(4):281.
54. Katayama M, Aoki M, Kawana S. Case of anaphylaxis caused by ingestion of royal jelly. J Dermatol . 2008;35(4):222-224
55. Leung R, Ho A, Chan J, Choy D, Lai CK. Royal jelly consumption and hypersensitivity in the community. Clin Exp Allergy . 1997;27(3):333-336.
56. Peacock S, Murray V, Turton C. Respiratory distress and royal jelly. BMJ . 1995;311(7018):1472.
57. Yonei Y, Shibagaki K, Tsukada N, et al. Case report: haemorrhagic colitis associated with royal jelly intake. J Gastroenterol Hepatol . 1997;12(7):495-499.

Copyright © 2009 Wolters Kluwer Health

(web3)