Rimexolone

Do not touch dropper tip to any surface, as this may contaminate the suspension.

Rimexolone ophthalmic is a steroid. It prevents the release of substances in the body that cause inflammation.

Rimexolone ophthalmic (for the eyes) is used to treat eye inflammation caused by infections, injury, surgery, or other conditions.

Rimexolone ophthalmic may also be used for purposes other than those listed in this medication guide.

Use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

• Suppresses the inflammatory response to mechanical, chemical, or immunologic agents.a b

• Corticosteroids inhibit edema, fibrin deposition, capillary dilation, leukocyte migration, capillary proliferation, fibroblast proliferation, deposition of collagen, and scar formation associated with inflammation.a b

• Presence of a methyl group at position C-21 may reduce the risk of increased IOP associated with topical ophthalmic corticosteroid therapy.

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about rimexolone, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about rimexolone. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using rimexolone.

Review Date: October 4, 2017

Suppresses the inflammatory response by inhibiting edema, capillary dilation, leukocyte migration and scar formation.

Absorption

Through aqueous humor

Metabolism

Hepatic for any amount of drug absorbed

Excretion

Urine and feces (>80%)

Half-Life Elimination

1 to 2 hours

Ophthalmic inflammatory conditions: Treatment of postoperative inflammation following ocular surgery; treatment of anterior uveitis

Store upright at 2°C to 25°C (36°F to 77°F). Do not freeze.

Adverse events have been observed in animal reproduction studies following subcutaneous administration. The amount of rimexolone absorbed systemically following ophthalmic administration is low (<80 to 470 pg/mL).

Patient advice:
-Do not touch dropper tip to any surface.

Storage requirements:
-Store upright.
-Do not freeze.
-Shake well before using.

This drug should be used during pregnancy only if the benefit outweighs the risk to the fetus. US FDA pregnancy category: C

Animal studies have shown this drug to be teratogenic and embryogenic. There are no adequate and well-controlled studies in pregnant women. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.