Riboflavin

Skip the missed dose if it is almost time for your next scheduled dose. Do not use extra medicine to make up the missed dose.

Follow your healthcare provider's instructions about any restrictions on food, beverages, or activity.

Water-soluble, B complex vitamin.a b

General

• Correct poor dietary habits and consider a multivitamin preparation containing riboflavin in patients with vitamin deficiencies since poor dietary habits often result in concurrent deficiencies.a

Administration

Administer orally.a e

May be given by IM injection or IV infusion as a component of a multivitamin injection.a A parenteral formulation containing riboflavin alone is not currently commercially available.a

Oral Administration

Administer orally, preferably with food.e

Dosage

Pediatric Patients

Usually, 3–10 mg daily.a

Infants <6 months of age: AI is 0.3 mg (0.04 mg/kg) daily.101

Infants 6–12 months of age: AI is 0.4 mg (0.04 mg/kg) daily.101

Children 1–3 years of age: RDA is 0.5 mg daily.101

Children 4–8 years of age: RDA is 0.6 mg daily.101

Children 9–13 years of age: RDA is 0.9 mg daily.101

Girls 14–19 years of age: RDA is 1 mg daily.101

Boys 14–19 years of age: RDA is 1.3 mg daily.101

Adults

Usually, 5–30 mg daily given in divided doses.a

Patients with normocytic, normochromic anemia: 10 mg daily usually increases reticulocyte count within a few days.a

Women ≥19 years of age: RDA is 1.1 mg daily.101

Men ≥19 years of age: RDA is 1.3 mg daily.101

These RDAs will not meet the needs of individuals with severe malabsorption.101 b

400 mg daily; maximal benefit may occur after 3 months of prophylaxis therapy.102

Special Populations

Pregnant women: RDA is 1.4 mg daily.101 Riboflavin intake exceeding this RDA may be needed by women who are pregnant with more than one fetus.101 b

Lactating women: RDA is 1.6 mg daily.101 Riboflavin intake exceeding this RDA may be needed by mothers nursing more than one infant.101 b

May require additional riboflavin intake in patients who are extremely physically active.b

Renal Impairment

Patients undergoing hemodialysis or peritoneal dialysis may require additional riboflavin.b

Storage

Oral

Tight, light-resistant containers at 15–30°C.a

Compatibility

For information on systemic interactions resulting from concomitant use, see Interactions.

Incompatible with alkaline solutions.a

• An exogenous source of riboflavin is required for tissue respiration.a

• Converts to coenzymes (FMN and FAD) involved in oxidation-reduction reactions of organic substrates and in intermediary metabolism.a b e

• Flavocoenzymes are involved in the formation of some vitamins and their coenzymes, including niacin, vitamin B6, and vitamin B12.101 b

• Indirectly involved in maintaining erythrocyte integrity.a

If you are taking this dietary supplement without a prescription, carefully read and follow any precautions on the label. For this supplement, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to riboflavin or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Problems in children have not been reported with intake of normal daily recommended amounts.

Geriatric

Problems in older adults have not been reported with intake of normal daily recommended amounts.

Breast Feeding

Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

• Store at room temperature.
• Store in a dry place. Do not store in a bathroom.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.

Oral:

Adequate intake:

1-6 months: 0.3 mg/day

7-12 months: 0.4 mg/day

Recommended daily intake:

1-3 years: 0.5 mg

4-8 years: 0.6 mg

9-13 years: 0.9 mg

14-18 years: Females: 1 mg; Males: 1.3 mg

There are no known significant interactions.

Other warnings/precautions:

• Vitamin deficiency: Single vitamin deficiency is rare; evaluate for other deficiencies.