Regadenoson

Pregnancy: No available data on therapy use in pregnant women to inform drug-associated risk; in animal reproduction studies, adverse developmental outcomes were observed with therapy administration to pregnant rats and rabbits during organogenesis only at doses that produced maternal toxicity

Lactation: There is no information on presence of regadenoson in human milk, effects on breastfed infant, or effects on milk production; because of potential risk of serious cardiac reactions in breastfed infant, advise nursing mother to pump and discard breast milk for 10 hr after therapy

Pregnancy Categories

A:Generally acceptable. Controlled studies in pregnant women show no evidence of fetal risk.

B:May be acceptable. Either animal studies show no risk but human studies not available or animal studies showed minor risks and human studies done and showed no risk.

C:Use with caution if benefits outweigh risks. Animal studies show risk and human studies not available or neither animal nor human studies done.

D:Use in LIFE-THREATENING emergencies when no safer drug available. Positive evidence of human fetal risk.

X:Do not use in pregnancy. Risks involved outweigh potential benefits. Safer alternatives exist.

NA:Information not available.

Regadenoson is injected into a vein through an IV. A healthcare provider will give you this injection.

After regadenoson is injected, you will be given other intravenous (IV) medications that allow blood vessels to be seen more clearly on the radiologic examination.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely during your stress test.

Since this medication is given by a healthcare professional in a medical setting, an overdose is unlikely to occur.

Since regadenoson is given by a healthcare professional in preparation for medical testing, you are not likely to be on a dosing schedule.

Regadenoson may be found in some form under the following brand names:

• Lexiscan

Regadenoson is injected into a vein through an IV. A healthcare provider will give you this injection.

After regadenoson is injected, you will be given other intravenous (IV) medications that allow blood vessels to be seen more clearly on the radiologic examination.

Your breathing, blood pressure, oxygen levels, and other vital signs will be watched closely during your stress test.

Since regadenoson is given by a healthcare professional in preparation for medical testing, you are not likely to be on a dosing schedule.

• Low affinity A2A adenosine receptor agonist.1 3 4 5 7 Activation of the A2A adenosine receptor induces coronary vasodilation and increases coronary blood flow.1 3

• Increases blood flow in normal coronary arteries with little or no increase in stenotic arteries, resulting in a greater difference in radiopharmaceutical uptake in myocardium supplied by normal versus stenotic coronary arteries.1

• Hemodynamic effects include reductions in BP and increases in heart rate.1

• Binds to the A1 adenosine receptor with at least tenfold lower affinity; no appreciable binding affinity for A2B and A3 receptors.1 3 4 5 7 A2B and A3 adenosine receptors have been implicated in the pathophysiology of bronchoconstriction in susceptible individuals (i.e., asthmatics).1 (See Respiratory Effects under Cautions.)

Excipients in commercially available drug preparations may have clinically important effects in some individuals; consult specific product labeling for details.

Please refer to the ASHP Drug Shortages Resource Center for information on shortages of one or more of these preparations.

• Tell all of your health care providers that you take regadenoson. This includes your doctors, nurses, pharmacists, and dentists.
• Heart attacks and heartbeats that are not normal have happened with this medicine. Sometimes this has been deadly. Talk with the doctor.
• If you are taking aminophylline, dipyridamole, theophylline, or any drug containing caffeine, talk with doctor. These drugs can affect how well regadenoson works.
• Do not eat or drink anything that has caffeine (for example, tea, coffee, cola, and chocolate) for 12 hours before using this medicine.
• This medicine may raise the chance of seizures in some people, including people who have had seizures in the past. Talk to your doctor to see if you have a greater chance of seizures while taking regadenoson.
• If you are 75 or older, use this medicine with care. You could have more side effects.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using regadenoson while you are pregnant.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
• Check with your pharmacist about how to throw out unused drugs.
• Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about this medicine, please talk with your doctor, nurse, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take regadenoson or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to regadenoson. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using this medicine.

Review Date: October 4, 2017

• Diagnostic Agent

Myocardial perfusion imaging: IV: 0.4 mg as a single dose

Applies to regadenoson: intravenous solution

Along with its needed effects, regadenoson may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking regadenoson:

• Arm, back, or jaw pain
• chest pain or discomfort
• difficult or labored breathing
• fast or irregular heartbeat
• nausea
• sweating
• tightness in the chest

• Confusion
• difficulty swallowing
• dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
• fainting
• irregular heartbeat recurrent
• large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
• puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
• rash, hives, or itching skin
• trembling or shaking of the hands or feet
• unusual tiredness or weakness

Get emergency help immediately if any of the following symptoms of overdose occur while taking regadenoson:

• Dizziness
• feeling of warmth
• increased heart rate
• redness of the face, neck, arms, and occasionally, upper chest

Some side effects of regadenoson may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Headache

• Change in taste
• loss of taste
• stomach soreness or discomfort

• Diarrhea
• difficulty with moving
• joint pain
• muscle aching or cramping