Razadyne ER

Razadyne ER is a prescription medication used to treat the symptoms of Alzheimer's disease. Razadyne ER belongs to a group of drugs called acetylcholinesterase inhibitors. These work by stopping a specific enzyme from breaking down acetylcholine in the brain.

This medication comes as an extended-release (long-acting) capsule and is taken once a day in the morning, with food.

Common side effects of Razadyne ER include nausea, vomiting, and diarrhea.

Razadyne ER can also cause dizziness. Do not drive or operate heavy machinery until you know how Razadyne ER affects you.

Razadyne ER is part of the drug class:

• Anticholinesterases

Tell your doctor if you are pregnant or plan to become pregnant.

The FDA categorizes medications based on safety for use during pregnancy. Five categories - A, B, C, D, and X, are used to classify the possible risks to an unborn baby when a medication is taken during pregnancy.

Razadyne ER falls into category C. In animal studies, pregnant animals were given this medication and had some babies born with problems. No well-controlled studies have been done in humans. Therefore, this medication may be used if the potential benefits to the mother outweigh the potential risks to the unborn child.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if Razadyne ER crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using Razadyne ER.

Take Razadyne ER exactly as prescribed.

This medication comes as an extended-release (long-acting) capsule and is taken once a day in the morning, with food.

Do not chew, divide, or break Razadyne ER capsules. Be sure to swallow extended-release capsules whole.

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of Razadyne ER at the same time.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include severe nausea, vomiting, stomach cramps, muscle weakness or spasm, watery eyes, drooling, increased urination or bowel movements, sweating, slow heart rate, feeling light-headed or fainting, and seizure (convulsions).

Tell your doctor about all your current medicines and any you start or stop using, especially:

• atropine;

• cold or allergy medicine that contains an antihistamine (Benadryl and others);

• medicine to treat Parkinson's disease;

• medicine to treat excess stomach acid, stomach ulcer, motion sickness, or irritable bowel syndrome;

• bladder or urinary medicines--darifenacin, fesoterodine, oxybutynin, tolterodine, solifenacin;

• bronchodilators--aclidinium, ipratropium, or tiotropium;

This list is not complete. Other drugs may interact with galantamine, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.

• It is used to treat dementia.
• It is used to treat Alzheimer's disease.

Common side effects of Razadyne ER include: nausea and vomiting. Other side effects include: dizziness, dyspepsia, fatigue, headache, weight loss, diarrhea, and anorexia. See below for a comprehensive list of adverse effects.

Applies to galantamine: oral capsule extended release, oral solution, oral tablet

Cardiovascular

Common (1% to 10%): Bradycardia
Uncommon (0.1% to 1%): First degree atrioventricular block, palpitations, sinus bradycardia, supraventricular extrasystoles, flushing, hypotension
Frequency not reported: Postural hypotension, dependent edema, cardiac failure, myocardial ischemia or infarction, atrial arrhythmias including atrial fibrillation and supraventricular tachycardia, QT prolonged, bundle branch block, T-wave inversion, chest pain and ventricular tachycardia
Postmarketing reports: Hypertension[Ref]

Dermatologic

Common (1% to 10%): Hyperhidrosis

Gastrointestinal

Very common (10% or more): Nausea, vomiting
Common (1% to 10%): Diarrhea, abdominal pain, upper abdominal pain, dyspepsia, stomach discomfort, abdominal discomfort
Uncommon (0.1% to 1%): Retching
Postmarketing reports: Upper and lower GI bleeding, stomach discomfort, and abdominal discomfort.[Ref]

General

The most common side effects associated with discontinuation were nausea, vomiting, decreased appetite, dizziness, diarrhea, headache, decreased weight, and abdominal pain.[Ref]

Genitourinary

Common (1% to 10%): Urinary tract infection, hematuria
Frequency not reported: Increased libido[Ref]

Hematologic

Common (1% to 10%): Anemia[Ref]

Hepatic

Postmarketing reports: Hepatitis, increased hepatic enzymes

Hypersensitivity

Postmarketing reports: Hypersensitivity

Metabolic

Common (1% to 10%): Decreased appetite, decreased weight, anorexia
Uncommon (0.1% to 1%): Dehydration

Musculoskeletal

Common (1% to 10%): Muscle spasms
Uncommon (0.1% to 1%): Muscular weakness

Nervous system

Common (1% to 10%): Dizziness, headache, tremor, syncope, lethargy, somnolence
Uncommon (0.1% to 1%): Dysgeusia, hypersomnia, paresthesia
Frequency not reported: Insomnia, leg cramps, transient ischemic attacks, cerebrovascular accidents
Postmarketing reports: Tinnitus[Ref]

Ocular

Uncommon (0.1% to 1%): Blurred vision

Other

Common (1% to 10%): Fatigue, asthenia, malaise
Uncommon (0.1% to 1%): Fall
Frequency not reported: Death in patients with mild cognitive impairment, fever

Psychiatric

Common (1% to 10%): Depression
Frequency not reported: Apathy, paranoia (disagreeable or terrifying dreams), paranoid reaction, increased libido, delirium, suicidal ideation and suicide
Postmarketing reports: Hallucination, visual hallucination, auditory hallucination[Ref]

Respiratory

Common (1% to 10%): Rhinitis[Ref]

Some side effects of Razadyne ER may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.