Phenylephrine

Name: Phenylephrine

Pharmacology

Mechanism of Action

Strong alpha effects resulting in increased peripheral vascular resistance and blood pressure; decreases cardiac output and renal perfusion

Absorption

Bioavailability: <38%

Onset: 10-15 min

Duration: 15 min

Peak plasma time: 0.75-2 hr

Distribution

Vdss: 184-543 L

Metabolism

Extensively metabolized in intestinal wall; moderately metabolized in liver

Metabolites: M-hydroxymandelic acid (inactive)

Elimination

Half-life: 2-3 hr (terminal phase)

Excretion: Urine (80-90%)

Phenylephrine Brand Names

Phenylephrine may be found in some form under the following brand names:

  • 4-Way

  • A-Tan 12X

  • AccuHist PDX

  • Actifed Cold & Allergy

  • Advil Allergy & Congestion Relief

  • Advil Congestion Relief

  • Aerohist Plus

  • Aerokid

  • Afrin Nasal

  • Ah-Chew

  • Ah-Chew D

  • Airacof

  • AK-Dilate

  • AK-Nefrin

  • Ala-Hist AC

  • Ala-Hist DHC

  • Ala-Hist DM

  • Ala-Hist PE

  • Alacol

  • Alacol DM

  • Albatussin SR

  • Aldex

  • Aldex CT

  • Aldex D

  • Aldex DM

  • Alenaze-D

  • Alka-Seltzer Plus Cold

  • Alka-Seltzer Plus Cold and Cough

  • Alka-Seltzer Plus Cold and Cough Effervescent

  • Alka-Seltzer Plus Cold and Sinus

  • Alka-Seltzer Plus Cold Reformulated Oct 2009

  • Alka-Seltzer Plus Cough and Cold Liquigel Reformulated Aug 2011

  • Alka-Seltzer Plus Day Cold

  • Alka-Seltzer Plus Day Severe Cold, Cough And Flu

  • Alka-Seltzer Plus Flu Reformulated Jan 2011

  • Alka-Seltzer Plus Night Cold

  • Alka-Seltzer Plus Night Cold and Flu

  • Alka-Seltzer Plus Night Severe Cold, Cough and Flu

  • Alka-Seltzer Plus Night Time Cold

  • Alka-Seltzer Plus Night Time Reformulated Dec 2006

  • Alka-Seltzer Plus Severe Allergy

  • Alka-Seltzer Plus Severe Cold, Mucus & Congestion

  • Alka-Seltzer Plus Severe Sinus Congestion and Cough

  • Allanhist PDX

  • Allerest PE

  • AllerTan

  • AlleRx

  • AlleRx PE AM

  • AlleRx PE PM

  • AlleRx PM Reformulated Apr 2008

  • Allerx Suspension

  • Amidal

  • Amitex LA

  • Andecon Pediatric Drops

  • Anextuss

  • Anusert Ointment

  • Aquatab C

  • Aquatab C Reformulated Oct 2008

  • Aquatab D

  • Aridex

  • Aridex-D

  • Atopalm Hemorrhoidal

  • Atrohist Plus

  • Atuss DM

  • Atuss DR

  • Atuss G

  • Atuss HD

  • Atuss MS

  • B-Tuss

  • Bactimicina Cough & Cold

  • Baczol Cold Medicine

  • Baczol Expectorant

  • Balacall DM

  • Balamine DM Reformulated Apr 2013

  • Baltussin

  • Banex

  • Benadryl Allergy Cold Reformulated Jun 2007

  • Benadryl Severe Allergy Sinus Headache Reformulated Jun 2007

  • Benadryl-D Allergy and Sinus

  • Betatan

  • Blanex-A

  • Brom Tann PE

  • Bromfed

  • Bromhist PDX Syrup

  • Bromophen TD

  • Bromtuss DM

  • Broncotron PED

  • Broncotron-D

  • Brovex D

  • Brovex PB

  • Brovex PBC

  • Brovex PBD

  • BroveX PEB

  • BroveX PEB DM

  • C Tan D

  • C-Tanna 12D

  • Canges-HC

  • Carbaphen CH

  • Carbaphen Ped CH

  • Carbatab

  • Carbatuss Syrup

  • Carbatuss-12

  • Carbatuss-CL

  • Carbetaplex

  • Carbetaplex TS

  • Cardec DM

  • Cardec DM Drops Reformulated Mar 2011

  • Cardec Drops

  • Centergy

  • Centergy DM

  • Centussin

  • Cerose DM

  • Certuss D

  • Chemdal

  • Chemdal HD

  • Chemtussin HC

  • Children's Mucinex Multi-Symptom Cold and Fever

  • Childrens Tylenol Plus Cold & Allergy

  • ChlorDex GP

  • Chlorgest HD

  • Chlorphen HD

  • ChlorTan D

  • Chlortox

  • Codimal DH

  • Codimal DM

  • Codimal PH

  • Coldex

  • Coldloc

  • Coldtuss-DR

  • Colrex

  • Comhist

  • Comtrex Cold and Cough Nighttime

  • Comtrex Cold and Cough Non Drowsy

  • Comtussin HC

  • Conal

  • Congestaid II

  • Contac Cold and Flu Maximum Strength

  • Contac Cold and Flu Non Drowsy Maximum Strength

  • Corfen-DM

  • Coryza-DM

  • Corzall-PE

  • Coughtuss

  • Counteract Day

  • Counteract Night

  • Covangesic

  • Crantex

  • Crantex ER

  • Crantex HC

  • Crantex LA

  • Cyclomydril

  • Cyndal HD

  • Cytuss HC

  • Cytuss-HC NR

  • D-Phen

  • D-Tab

  • D.a. Ii

  • Dacex DM

  • Dacex-A

  • Dacex-PE

  • Dallergy Drops

  • Dallergy Reformulated Nov 2011

  • Dallergy-JR

  • Dayquil Cold & Flu

  • Dayquil Severe Cold & Flu

  • DayQuil Sinex

  • De-Chlor DR

  • De-Chlor G

  • De-Chlor HC

  • De-Chlor HD

  • De-Chlor MR

  • Deconex

  • Deconex DM

  • Decongestabs

  • Deconhist LA

  • Deconsal CT

  • Deconsal DM

  • Deconsal II

  • Deconsal Pediatric

  • Delsym Adult Night Time Multi-Symptom

  • Delsym Children's Nighttime Cough and Cold

  • Delsym Children's Nighttime Cough and Cold Reformulated Apr 2013

  • Delsym Cough Plus Cold Daytime

  • Delsym Cough Plus Cold Night Time

  • Delsym Night Time Cough and Cold Reformulated Jan 2012

  • Demi-Cof

  • Denaze

  • Despec

  • Despec DM Reformulated Sep 2008

  • Despec EDA

  • Despec-SF

  • Dexall

  • Dexcon-DM

  • Dexcon-PE

  • Dicomal-DH

  • Dicomal-PH

  • Dilotab

  • Dimetane Decongestant

  • Dimetapp Children's Cold and Allergy Reformulated Jan 2011

  • Dimetapp Cold

  • Dimetapp Cold Drops

  • Dimetapp DM Cold & Cough

  • Dimetapp Nighttime Cold & Congestion

  • Dimetapp Nighttime Flu

  • Ditussin-HC

  • Donatuss DC

  • Donatussin DC

  • Donatussin DM Drops

  • Donatussin Drops

  • Donatussin MAX

  • Donatussin Pediatric

  • Donatussin Syrup

  • Dristan

  • Dristan Cold Multi Symptom

  • Drize

  • Drotuss CP

  • Drysec

  • Duo-Medihaler

  • Duomax

  • Dura-Gest

  • Dura-Vent/DA

  • Duradal HD

  • Duradal HD Plus

  • Duradryl

  • Durahist

  • DuraMAX

  • Duraphen 1000

  • Duraphen DM

  • Duraphen Forte

  • Duraphen II

  • Duraphen II DM

  • DuraTan DM

  • DuraTan PE

  • Duratex

  • Duratuss

  • Duratuss AC 12

  • Duratuss GP

  • Duratuss PE

  • Duratuss-A

  • Duravent

  • Duravent DPB

  • Dynatuss HC

  • Dynex LA

  • Dytan-CD

  • Dytan-CS

  • Dytan-D

  • Dytan-D Chewable

  • Dytan-DM

  • Dytan-HC

  • Ear-gesic

  • Echotuss-HC

  • Ed-TLC

  • Ed-Tuss HC

  • Efasin

  • Efasin-HD

  • Emagrin Forte

  • Endacon

  • Endagen-HD

  • Endal

  • Endal CD

  • Endal Cough

  • Endal HD

  • Endal-HD Plus

  • Enditussin-HD

  • Endotuss-HD

  • Enomine

  • Enplus-HD

  • Entac

  • Entex ER

  • Entex HC

  • Entex LQ

  • Equi-Tex

  • Ex-Tuss

  • Excedrin Sinus Headache Caplet

  • Excof

  • ExeTuss

  • ExeTuss-DM

  • ExeTuss-GP

  • Exetuss-HC

  • Exo-Tuss

  • Exratuss

  • Extendryl

  • Extendryl G

  • Extendryl GCP

  • Extendryl PEM

  • Fentex

  • FluTuss HC

  • Formulation R

  • Formulation R Ointment

  • G-Phen DM

  • Gdp-ex

  • Genelan

  • Genepatuss

  • Genetuss 2

  • Gentex HC

  • Gentex LA

  • Gentex LQ

  • Gilphex

  • Giltuss

  • GRX Hemorrhoidal

  • Guaifed

  • Guaifenex

  • Guaiphen-PD

  • Guaphen Forte

  • Guaphen II DM

  • Guiaphen HD

  • Guiaplex HC

  • H-C Tussive

  • H-C Tussive-NR

  • Hemaway

  • Hemorid

  • Hemorid Cream

  • Hemorid Ointment

  • Hi-Tuss HC

  • Hista-Vadrin

  • Hista-Vent DA

  • Histadec

  • HistadecDM

  • HistamaxD

  • Histatan

  • Histenol

  • Histinex HC

  • Histussin-HC

  • Hyco-DH

  • Hycomal DH

  • Hycomine Compound

  • Hydro GP

  • Hydro-PC II

  • HYDROcodone CP

  • HYDROcodone HD

  • Hydrofed

  • Hydron CP

  • Hydrophene DH

  • Hyphen-HD

  • Iodal HD

  • Isopto Frin

  • J-Max

  • K-Tan

  • KG-Dal HD

  • Kids-Eeze Cough & Cold

  • L-All 12

  • L-All 12 NF

  • Levall

  • Levall 5.0

  • Levall-12

  • Liquibid DR

  • Liquibid PDR

  • Liquibid-D

  • Liquibid-PD

  • Liquicough HC

  • Liquitex

  • Little Colds

  • Little Noses Decongestant

  • Little Remedies for Colds Decongestant Plus Cough

  • Lortuss HC

  • Lusair

  • Lusonal

  • Lusonex

  • LuSonex Plus

  • M-End PE

  • M-Phen

  • Mapap Cold Formula

  • Mapap Sinus Congestion and Pain

  • Max HC

  • Maxi-Tuss HC

  • Maxi-Tuss SA

  • Maxichlor PEH

  • Maxichlor PEH DM

  • Maxiphen

  • Maxiphen ADT

  • Maxiphen CD

  • Maxiphen CDX

  • Maxiphen DM

  • Maxiphen DM Reformulated Jul 2008

  • Maxiphen Reformulated Jul 2008

  • Maxiphen-G DM

  • Med-Hist-HC

  • Medent-PE

  • Medent-PEI

  • Medicone Hemorrhoidal

  • Mintuss G

  • Mintuss MR

  • Mintuss MS

  • MonteCough

  • MonteFlu HC

  • MontePhen

  • Mucinex Children's Multi-Symptom Cold

  • Mucinex Children's Night Time Multi-Symptom Cold

  • Mucinex Cold

  • Mucinex Fast-Max Cold and Sinus

  • Mucinex Fast-Max Cold, Flu and Sore Throat

  • Mucinex Fast-Max Night Time Cold and Flu

  • Mucinex Fast-Max Severe Cold

  • Mucinex Fast-Max Severe Congestion and Cough

  • Mucinex Sinus-Max Day

  • Mucinex Sinus-Max Night

  • Mucinex Sinus-Max Pressure and Pain

  • Mucinex Sinus-Max Severe Congestion Relief

  • Murocoll 2

  • Myci Spray

  • Mydex

  • Mydfrin

  • MyDocs

  • Mygrex

  • Mytex

  • Nalda-Relief Pediatric

  • Naldecon

  • Naldelate

  • Nalex A 12

  • Nalex-A

  • Nalex-DH

  • Nalgest

  • Nalgestic Pediatric

  • Nalphen Pediatric

  • Nalspan

  • Nariz

  • Nariz HC

  • Nasatuss

  • Nasex

  • Nasohist

  • Nasohist-DM

  • Nasop

  • Nasop Suspension

  • Nasopen PE

  • Nasopen-CH

  • Nasotuss

  • Nature Fusion Cold & Flu

  • Nazarin

  • Nazarin HC

  • Neo-Synephrine

  • Neotuss Improved

  • Neotuss Plus

  • Nescon-PD

  • Nexphen PD

  • Nohist-DMX

  • Norel

  • Norel AD

  • Norel CS

  • Norel DM

  • Norel EX

  • Norel LA

  • Norel SD

  • Norel SR

  • Notuss PD

  • Notuss PE

  • Novahistine DH Reformulated Oct 2008

  • Novahistine Elixir

  • Ny-Tannic

  • Nyquil Severe Cold & Flu

  • NyQuil Sinex

  • Omnihist

  • Onetab Cold and Flu

  • Onset Forte

  • Otigesic

  • P-Hist

  • P-Tann D

  • Panadol Cold & Flu Non Drowsy

  • Panatuss DXP

  • Panatuss DXP Pediatric

  • Panatuss DXP Pediatric Reformulated Jun 2012

  • Pancof-PD

  • PE-Guai

  • PediaCare Children's Allergy & Cold

  • Pediacare Children's Flu Plus APAP

  • PediaCare Children's Multi-Symptom Cold

  • PediaCare Children's Multi-Symptom Cold Plus APAP

  • Pediacare Decongestant

  • Pediacare Multi Symptom Cold

  • Pediacof

  • PediaTan D

  • Pedituss

  • Pendex

  • Phena-HC

  • Phena-Plus

  • Phena-S

  • Phenavent

  • Phenavent D

  • Phenavent LA

  • Phenchlor S.H.A.

  • Phendal-HD

  • Phenergan VC

  • Phenergan VC with Codeine

  • Phenflu CD

  • Phenflu DM

  • Phentex

  • Phenyl-T

  • Phenylfenesin

  • Phenylhistine

  • Phlemex Forte

  • Phlemex-PE

  • Pluratuss

  • Poly Hist DHC

  • Poly Hist DM

  • Poly Hist Forte

  • Poly Hist HC

  • Poly Hist PD

  • Poly Tussin EX

  • Poly-Tussin

  • Poly-Tussin AC

  • Poly-Tussin DHC

  • Poly-Tussin DM

  • Prefrin

  • Prep-Hem

  • Preparation H

  • Preparation H Cooling Gel

  • Preparation H Cream

  • Preparation H Reformulated Jun 2013

  • Preparation H Suppositories

  • Presgen

  • ProHist

  • Prohist CD

  • Prohist LQ

  • Prolex D

  • Prolex PD

  • Prop-A-Hist

  • Protid

  • Protuss Tablet

  • Pulmari

  • Pyril D

  • Pyril DM

  • Pyril Tann-12

  • Pyrlex PD

  • Pyrroxate Cold & Congestion

  • Q-Hist LA

  • Q-Tuss

  • Q-Tuss with HYDROcodone

  • Quad Tann

  • Quadrahist Pediatric

  • Qual-Tussin

  • Qual-Tussin DC

  • Qual-Tussin Pediatric

  • Quartuss

  • Quartuss DM

  • Quindal

  • Quindal HD

  • Quintex

  • R-Tannic-S A/D

  • Ralix

  • Re All 12

  • Re-Drylex

  • Re-Drylex Jr.

  • Redur-PCM

  • Refenesen PE

  • Refresh Redness Relief

  • Relacon-HC

  • Relahist-DM

  • Relasin-HC

  • Relcof PE

  • Relera

  • Reluri

  • Reme Hist DM

  • Rescon Jr Reformulated Feb 2010

  • Rescon MX

  • Rescon Reformulated Jul 2010

  • Rescon Reformulated Jun 2008

  • Rescon-GG

  • Rescon-MX Reformulated Feb 2009

  • Rescon-MX Reformulated Jan 2010

  • Respa C&C

  • Respa-A.R.M.

  • Respa-PE

  • Respahist II

  • Resperal

  • Rhinabid

  • Rhinabid PD

  • Rhinacon A

  • RhinaHist

  • Rhinall

  • Rhinogesic

  • Rindal HPD

  • Rindal-HD

  • Robafen CF

  • Robitussin Children's Cough & Cold CF

  • Robitussin Cough & Cold CF

  • Robitussin Head & Chest Congestion

  • Robitussin Night Time Cough & Cold

  • Robitussin Peak Cold Daytime Cold Plus Flu

  • Robitussin Peak Cold Maximum Strength Multi-Symptom Cold

  • Robitussin Peak Cold Multi-Symptom Cold

  • Robitussin Peak Cold Nasal

  • Robitussin Peak Cold Nighttime Multi-Symptom Cold

  • Robitussin Peak Cold Nighttime Nasal Relief

  • Robitussin Pediatric Cough & Cold Nighttime

  • Rolatuss

  • Rolatuss with HYDROcodone

  • Rolatuss-SR

  • Rompe Pecho CF

  • Rompe Pecho-SF

  • Rondex

  • Rondex-DM

  • Rondex-DM Drops

  • Ru Hist D

  • RU Hist Forte

  • Ru-Tab

  • Rutuss

  • Rx-Act Children's Cold and Allergy

  • Rx-Act Cold Head Congestion

  • Rx-Act Flu & Severe Cold & Cough

  • Rx-Act Flu & Sore Throat

  • Rx-Act Nasal Decongestant PE

  • Rx-Act Nasal Four

  • Rx-Act Sinus & Allergy PE

  • Rx-Act Sinus Congestion & Pain

  • Rx-Act Tussin CF

  • Ry-T-12

  • Ry-Tann

  • Rymed-D

  • Ryna-12

  • Ryna-12X

  • Rynatan Pediatric

  • Rynatan-S Pediatric

  • Rynatuss

  • Rynex-DM

  • S-T Forte

  • Safetussin CD

  • Sanatos Cold Multi-Symptom Daytime

  • Sanatos Cold Multi-Symptom Nighttime

  • Sanatos Day

  • Scot Tussin Original

  • Scot-Tussin Multisymptom Cold and Allergy

  • Seradex

  • Seradex-LA

  • Sil-Tex

  • Simuc

  • Simuc-HD

  • Sina-12X

  • Sine-Off Maximum Strength Reformulated Sep 2008

  • Sine-Off Sinus and Cold

  • Sinex

  • Sinucon

  • Sinupan

  • Sinutab Sinus

  • Sinutuss DM

  • SINUvent PE

  • Sitrex

  • Sonahist

  • Sonahist-DM

  • Spec-T Sore Throat/Decongestant

  • Stahist

  • Statuss DM

  • Statuss Green

  • Stona

  • Stona Cough

  • Stonarhini

  • Sudafed PE

  • Sudafed PE Children's Cold & Cough

  • Sudafed PE Children's Nasal Decongestant

  • Sudafed PE Cold & Cough

  • Sudafed PE Nighttime Cold

  • Sudafed PE Non-Drying Sinus

  • Sudafed PE Pressure Plus Pain Plus Cough

  • Sudafed PE Pressure Plus Pain Plus Mucus

  • Sudafed PE Pressure, Pain & Cold

  • Sudafed PE Severe Cold

  • Sudafed PE Sinus & Allergy

  • Sudafed PE Sinus Headache

  • Sudafed PE Triple Action

  • Sudex

  • Sudo-Tab

  • Sudogest PE

  • T- Koff

  • Tabcin

  • Tanabid SR

  • Tanahist-D

  • Tannate 12D S

  • Tannate V DM

  • Tanni-Hist 12

  • Tanni-Hist 12 RF

  • Tannic-12

  • Tannihist-12D

  • Theraflu Cold & Cough

  • Theraflu Cold & Sore Throat

  • Theraflu Daytime Severe Cold & Cough

  • Theraflu Flu & Sore Throat

  • Theraflu Nighttime Severe Cold

  • Theraflu Severe Cold & Cough Nighttime

  • Theraflu Severe Cold Nighttime

  • Theraflu Warming Cold & Chest Congestion

  • Theraflu Warming Relief

  • TL-Hist CD

  • TL-Hist DM

  • Trexbrom

  • Trexbrom Reformulated Jun 2011

  • Tri-Gestan S

  • Tri-Phen-Chlor

  • Tri-Phen-Mine

  • Tri-Tex

  • Triall

  • Triaminic Chest & Nasal Congestion

  • Triaminic Cold & Allergy

  • Triaminic Day Time Cold & Cough

  • Triaminic Night Time Cold & Cough

  • Triaminic Thin Strips Cold

  • Triant-HC

  • Tricold

  • Trimal DH

  • Triplex AD

  • Triplex DM

  • Trital DM

  • Tritan

  • TriTuss

  • Tukol

  • Tusana-D

  • Tusdec-DM

  • Tusdec-HC

  • Tusicof

  • Tuss-DS

  • Tuss-HC

  • Tuss-PD

  • Tussafed-EX

  • Tussafed-EX Drops

  • Tussafed-HC

  • Tussall

  • Tussall-ER

  • Tussar DM

  • Tussbid

  • Tusscough DHC

  • Tussex

  • Tussi Pres B Reformulated Aug 2011

  • Tussi-12D

  • Tussi-12D S

  • Tussi-Pres

  • Tussi-Pres PE

  • Tussinate

  • Tussirex

  • Tussive HC

  • Tusso-DM

  • Tusso-DMR

  • Tusso-XR

  • Tussplex

  • Tylenol Allergy Multi-Symptom

  • Tylenol Allergy Multi-Symptom Nighttime

  • Tylenol Children's Multi-Symptom Cold Plus

  • Tylenol Children's Plus Cold & Cough

  • Tylenol Children's Plus Cold Reformulated Mar 2013

  • Tylenol Cold Head Congestion Severe

  • Tylenol Cold Multi-Symptom Daytime

  • Tylenol Cold Multi-Symptom Nighttime

  • Tylenol Cold Multi-Symptom Nighttime Liquid

  • Tylenol Cold Multi-Symptom Severe Daytime

  • Tylenol Sinus Congestion & Pain Severe

  • Tylenol Sinus Congestion and Pain Daytime

  • Tympagesic

  • Uni All 12

  • Uni Decon

  • Uni Hist PDX

  • Uni Tuss HC

  • Uni-Lev 5.0

  • Uni-Tricof HC

  • V-Cof

  • V-Tan DM

  • Vanacof

  • Vanacof APE

  • Vanacof DM

  • Vanacof GPE

  • Vanacof-PE

  • Vanex Forte

  • Vanex Forte-D

  • Vanex-HD

  • Vasosulf

  • Vazobid-PD

  • VaZol D

  • Vazotab

  • Vazotan

  • Vazotuss HC

  • Ventuss

  • Vetuss HC Syrup

  • Vicks Vaposyrup

  • Viratan-DM

  • Viravan-S

  • Viravan-T

  • Visonex

  • Wal-Dryl Severe Allergy & Sinus

  • Wal-Dryl-D

  • Wal-Flu Cold and Sore Throat

  • Wal-Flu Daytime Severe Cold and Cough

  • Wal-Flu Flu and Sore Throat

  • Wal-Flu Severe Cold

  • Wal-Flu Severe Cold and Cough

  • Wal-Four

  • Wal-Phed Cold & Cough

  • Wal-Phed PE

  • Wal-Phed PE Cold & Cough Multi-Symptom Daytime

  • Wal-Phed PE Cold Multi-Symptom Nighttime

  • Wal-Phed PE Non-Drying Sinus

  • Wal-Phed PE Severe Cold

  • Wal-Phed PE Sinus & Allergy

  • Wal-Phed PE Triple Relief

  • Wal-Tap Children's Cold & Allergy

  • Wal-Tap DM

  • Wal-Tussin CF

  • Wellbid-D

  • West-Decon

  • West-Decon M

  • X-Hist

  • X-Hist DM

  • Xedec

  • XiraHist

  • XiraHist DM

  • XiraTuss

  • Xpect-PE

  • Y-Cof DM

  • Z-Cof HC

  • Z-Dex

  • Z-tuss DM

  • Zicam Cough Plus D

  • Zicam Flu Nighttime

  • Zincfrin

  • Zotex

  • Zotex GPX

  • Zotex HC

  • Zotex PE

  • Zotex-12

  • Zotex-12D

  • Zotex-C

  • Zyrphen

Phenylephrine Drug Class

Phenylephrine is part of the drug class:

  • Sympathomimetics

Side Effects of Phenylephrine

Serious side effects have been reported with phenylephrine. See the “Phenylephrine Precautions” section.

Topical:

Common side effects of phenylephrine ophthalmic solution include the following:

  • eye pain and stinging
  • blurred vision
  • sensitivity to light
  • increased blood pressure
  • fast or irregular heart beat

Injectable:

Common side effects of phenylephrine for injection include the following:

  • nausea
  • vomiting
  • headache

This is not a complete list of phenylephrine side effects. Ask your doctor or pharmacist for more information.

Tell your doctor if you have any side effect that bothers you or that does not go away.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Phenylephrine Food Interactions

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of phenylephrine, there are no specific foods that you must exclude from your diet when receiving this medication.

Inform MD

Before taking phenylephrine, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to phenylephrine or to any of its ingredients
  • have thyroid problems
  • have heart problems
  • have high blood pressure
  • have diabetes
  • have trouble urinating because of an enlarged prostate gland
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Phenylephrine Usage

Take phenylephrine exactly as prescribed.

Topical:

This medication comes in solution form and is instilled directly into the eye. It is usually administered by a healthcare provider immediately prior to eye examinations or procedures.

Injectable:

This medication comes in solution form and is injected into a vein by a healthcare professional during surgical procedures.

What other drugs will affect phenylephrine?

Ask a doctor or pharmacist before using this medicine if you are also using any other drugs, including prescription and over-the-counter medicines, vitamins, and herbal products. Some medicines can cause unwanted or dangerous effects when used together. Not all possible interactions are listed in this medication guide.

Taking this medicine with other drugs that make you sleepy or slow your breathing can worsen these effects. Ask your doctor before taking phenylephrine with a sleeping pill, narcotic pain medicine, muscle relaxer, or medicine for anxiety, depression, or seizures.

For the Consumer

Applies to phenylephrine: intravenous solution

Along with its needed effects, phenylephrine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking phenylephrine:

Incidence not known
  • Blurred vision
  • chest pain or discomfort
  • difficult or labored breathing
  • dizziness
  • fainting
  • fast, slow, or irregular heartbeat
  • headache
  • nausea or vomiting
  • nervousness
  • pain in the shoulders, arms, jaw, or neck
  • pounding in the ears
  • sweating
  • tightness in the chest
  • unusual tiredness

Get emergency help immediately if any of the following symptoms of overdose occur while taking phenylephrine:

Symptoms of overdose
  • Feeling of fullness in the head
  • pounding or rapid pulse
  • tingling in the arms or legs
  • vomiting

Some side effects of phenylephrine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known
  • Heartburn
  • itching skin
  • nausea
  • pain in the neck
  • pain or discomfort in chest, upper stomach, or throat

For Healthcare Professionals

Applies to phenylephrine: compounding powder, injectable solution, intravenous solution, oral disintegrating strip, oral liquid, oral suspension extended release, oral tablet, oral tablet chewable, oral tablet chewable extended release, oral tablet disintegrating

Nervous system

Nervous system side effects have included headache, dizziness, nervousness, restlessness, tremor, insomnia, convulsions, and central nervous system depression.[Ref]

Cardiovascular

Cardiovascular side effects have included palpitations, arrhythmias, and cardiovascular collapse with hypotension.[Ref]

Psychiatric

Psychiatric side effects have included hallucinations, fear, and anxiety.[Ref]

Gastrointestinal

Gastrointestinal side effects have included nausea.[Ref]

Respiratory

Respiratory side effects have included respiratory difficulty.[Ref]

Genitourinary

Genitourinary side effects have included dysuria.[Ref]

General

General side effects have included pallor and weakness.[Ref]

Some side effects of phenylephrine may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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