Pemoline

See WARNINGS, CONTRAINDICATIONS, and PRECAUTIONS.

Pemoline may be found in some form under the following brand names:

• Cylert

• Pemolert

Take pemoline exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The Pemoline dose your doctor recommends will be based on the following (use any or all that apply):

• the condition being treated
• other medical conditions you have
• other medications you are taking
• how you respond to this medication
• your weight
• your height
• your age
• your gender

Pemoline is available in the following doses:

• Pemoline 18.75 Mg Oral Tablet
• Pemoline 37.5 Mg Oral Tablet
• Pemoline 37.5 Mg Oral Tablet, Chewable
• Pemoline 75 Mg Oral Tablet

In the U.S.

• Cylert

Available Dosage Forms:

• Tablet
• Tablet, Chewable

Therapeutic Class: CNS Stimulant

Chemical Class: Amphetamine Related

For patients taking the chewable tablet form of pemoline:

• These tablets must be chewed before swallowing. Do not swallow whole.

Sometimes pemoline must be taken for 3 to 4 weeks before improvement is noticed.

Take pemoline only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered. If too much is taken, it may become habit-forming.

Dosing

The dose of pemoline will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of pemoline. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

• For oral or chewable dosage forms (tablets):
  • Children 6 years of age and over—To start, 37.5 milligrams (mg) every morning. Your doctor may increase your dose if needed. However, the dose is usually not more than 112.5 mg a day.
  • Children up to 6 years of age—Use and dose must be determined by the doctor.

Missed Dose

If you miss a dose of pemoline, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Applies to pemoline: oral tablet, oral tablet chewable

Along with its needed effects, pemoline may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests.

Pemoline may cause some serious side effects, including liver problems. Also, medicines like pemoline, when used for a long time, have been reported to slow the growth rate of children. Some doctors recommend medicine-free periods during treatment with pemoline. Pemoline may also cause unwanted effects on behavior in children with severe mental illness.

Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking pemoline:

• Dark urine
• yellow eyes or skin

Check with your doctor as soon as possible if any of the following side effects occur while taking pemoline:

• Convulsions (seizures)
• hallucinations (seeing, hearing, or feeling things that are not there)
• nausea and vomiting
• shortness of breath, troubled breathing, wheezing, or tightness in chest
• skin rash
• sores, ulcers, or white spots on lips or in mouth
• swollen or painful glands
• uncontrolled movements of eyes, tongue, lips, face, arms, or legs
• unusual bleeding or bruising
• unusual tiredness
• vocal sounds you cannot control

• Agitation
• confusion
• convulsions (seizures)may be followed by coma
• false sense of well-being
• fast heartbeat
• hallucinations (seeing, hearing, or feeling things that are not there)
• headache (severe)
• high blood pressure
• high fever
• large pupils
• muscle trembling or twitching
• restlessness
• sweating
• vomiting

This medicine may also cause the following side effects that your doctor will watch for:

• Liver problems
• slow growth in children

Some side effects of pemoline may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Loss of appetite
• trouble in sleeping
• weight loss

• Dizziness
• drowsiness
• headache
• increased irritability
• mental depression
• stomachache

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

• Abdominal pain
• convulsions (seizures)
• headache
• mental depression
• nausea
• unusual behavior
• unusual tiredness or weakness
• vomiting