Oxybutynin Topical
Name: Oxybutynin Topical
Pharmacology
Mechanism of Action
Exerts antispasmodic and antimuscarinic effects on smooth muscle; decreases uninhibited urinary contractions, and delays desire to void; increases bladder capacity
Pharmacokinetics
Vd: 193 L (IV)
Peak Plasma Concentration: 6.8-8.3 ng/mL (gel)
Metabolism: bypasses first-pass in liver by CYP3A4, AUC ratio of N-desethyloxybutynin (active metabolite) to parent compound is 1:1