Orphenadrine Oral Tablet

Name: Orphenadrine Oral Tablet

Highlights for orphenadrine

Orphenadrine is used to treat muscle pain from musculoskeletal conditions. It’s used with rest, physical therapy, and other treatments.

This drug is available as an extended-release tablet you take by mouth. It’s also available as intravenous (IV) and intramuscular (IM) injections, which are only given by a healthcare provider.

Orphenadrine is only available as a generic drug.

IMPORTANT INFORMATION
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What is orphenadrine?

This drug is a prescription drug. It’s available as an extended-release oral tablet. An extended-release tablet releases the drug into your body slowly. This drug is also available as intravenous (IV) and intramuscular (IM) injections, which are only given by a healthcare provider.

Orphenadrine is only available as a generic drug.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it's used

This drug is used to treat muscle pain from musculoskeletal conditions. It’s used with rest, physical therapy, and other treatments.

How it works

This drug belongs to a class of drugs called anticholinergic drugs.

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Orphenadrine Side Effects

More common side effects

The more common side effects of orphenadrine can include:

  • dry mouth

  • fast heart rate

  • trouble urinating

  • blurry vision

  • dialated pupils

  • higher blood pressure in your eyes

  • weakness

  • nausea

  • vomiting

  • headache

  • dizziness

  • constipation

  • drowsiness

  • itching, hoves, or rash on your skin

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious side effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:
  • Nervous system side effects. Symptoms can include:

    • hallucinations (seeing or hearing things that aren’t really there)
    • agitation
    • anxiousness
    • irritation
    • confusion
    • tremors
  • Anemia. Symptoms can include:

    • weakness
    • fast heart rate
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.

Orphenadrine May Interact with Other Medications

Orphenadrine can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Alcohol interaction

Drinking alcohol can increase your risk of drowsiness and dizziness from this drug. If you drink alcohol, talk to your doctor.

Medications that might interact with this drug

Interactions that increase your risk of side effects

Increased side effects from orphenadrine: Taking orphenadrine with certain medications raises your risk of side effects from orphenadrine. This is because the amount of orphenadrine in your body may be increased. Examples of these drugs include:

  • Amantadine
  • Depression drugs such as bupropion and nortriptyline
  • Cyclobenzaprine
  • Antihistamines such as diphenhydramine and meclizine
  • Sleep drugs such as zaleplon and zolpidem
  • Tramadol
  • Diazepam

Increased side effects from other drugs: Taking orphenadrine with certain medications raises your risk of side effects from these drugs. Examples of these drugs include:

  • Propoxyphene
    • Increased side effects can include confusion, anxiety, and tremors. If you have these side effects, your doctor may lower your dosage or stop your treatment with either drug.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking. Drug warnings

People with heart problems

If you have heart failure, reduced blood flow to your heart, or a fast or irregular heart rate, ask your doctor if this drug is safe for you. This drug may make your condition worse.

People with eye problems

This drug can increase the blood pressure in your eyes. You should not use this drug if you have glaucoma. It can make your glaucoma worse. Tell your doctor if you have a history of eye problems before taking this drug.

People with stomach problems

You should not use this drug if you have certain kinds of ulcers or any blockage in your digestive tract. Tell your doctor if you have a history of stomach problems. Your doctor will decide if this drug is safe for you.

People with prostate or bladder problems

You should not use this drug if you have an enlarged prostate or a blockage of your urinary bladder neck. Tell your doctor if you have a history of prostate or bladder problems. Your doctor will decide if this drug is safe for you.

People with myasthenia gravis

You should not use this drug. It can make your condition worse.

Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect a pregnancy.

Talk to your doctor if you’re pregnant or plan to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the pregnancy.

Women who are breast-feeding

It isn’t known if this drug passes into breast milk. If it does, it may cause side effects in a child who is breastfed.

Talk to your doctor if you breastfeed your child. You may need to decide whether to stop breastfeeding or stop taking this medication.

For children

This medication has not been studied in children. It should not be used in people younger than 18 years.

When to call the doctor

Call your doctor right away if you become pregnant while taking this drug.

Allegies

This drug can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your throat or tongue

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

How to Take orphenadrine (Dosage)

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

The dosage information below is for the conditions that orphenadrine is most often prescribed to treat. This list may not contain all conditions that your doctor can prescribe this drug for. If you have questions about your prescription, talk with your doctor.

What are you taking this medication for?

Muscle pain

Generic: Orphenadrine

Form: Oral tablet Strength: 100 mg Adult dosage (ages 18 years and older)
  • Typical starting dosage: 200 mg per day. You’ll take one 100-mg tablet in the morning and one 100-mg tablet in the evening.
Child dosage (ages 0–17 years)

This medication has not been studied in children. It should not be used in people younger than 18 years.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you. Important considerations for taking this drug

You can take this drug with or without food

Take this drug at the time(s) recommended by your doctor

Do not crush or chew the tablet. Swallow the tablet whole

Store this drug carefully

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A prescription for this medication is refillable

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Travel

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Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead

Insurance

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Are there any alternatives?

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