Oestrogel

Name: Oestrogel

Oestrogel Drug Class

Oestrogel is part of the drug class:

  • Natural and semisynthetic estrogens, plain

Oestrogel Interactions

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take:

  • Amiodarone (Cordarone, Pacerone)
  • Antifungals such as itraconazole (Sporanox) and ketoconazole (Nizoral)
  • Aprepitant (Emend)
  • Carbamazepine (Carbatrol, Epitol, Tegretol)
  • Cimetidine (Tagamet)
  • Clarithromycin (Biaxin)
  • Cyclosporine (Neoral, Sandimmune)
  • Dexamethasone (Decadron, Dexpak)
  • Diltiazem (Cardizem, Dilacor, Tiazac, others)
  • Erythromycin (E.E.S, Erythrocin)
  • Fluoxetine (Prozac, Sarafem)
  • Fluvoxamine (Luvox)
  • Griseofulvin (Fulvicin, Grifulvin, Gris-PEG)
  • Lovastatin (Altocor, Mevacor)
  • Medications for human immunodeficiency virus (HIV) or acquired immunodeficiency syndrome (AIDS) such as atazanavir (Reyataz), delaviridine (Rescriptor), efavirenz (Sustiva), indinavir (Crixivan), lopinavir (in Kaletra),nelfinavir (Viracept), nevirapine (Viramune), ritonavir (Norvir, in Kaletra), and saquinavir (Fortovase, Invirase)
  • Medications for thyroid disease
  • Nefazodone
  • Other medications that contain estrogen
  • Phenobarbital
  • Phenytoin (Dilantin, Phenytek); rifabutin (Mycobutin)
  • Rifampin (Rifadin, Rimactane, in Rifamate)
  • Sertraline (Zoloft)
  • Troleandomycin (TAO)
  • Verapamil (Calan, Covera, Isoptin, Verelan)
  • Zafirlukast (Accolate)
  • St. John's Wort

This is not a complete list of estradiol drug interactions. Ask your doctor or pharmacist for more information.

Inform MD

Before taking estradiol, tell your doctor about all of your medical conditions. Especially tell your doctor if you:

  • are allergic to estradiol or to any of its ingredients
  • have or have ever had asthma
  • have seizures
  • have migraine headaches
  • have endometriosis (a condition in which the type of tissue that lines the uterus [womb] grows in other areas of the body)
  • have uterine fibroids (growths in the uterus that are not cancer)
  • have or have had yellowing of the skin or eyes, especially during pregnancy or while you were using an estrogen product
  • have very high or very low levels of calcium in your blood
  • have porphyria (condition in which abnormal substances build up in the blood and cause problems with the skin or nervous system) or gallbladder, thyroid, pancreas, liver or kidney disease
  • are pregnant or breastfeeding

Tell your doctor about all the medicines you take including prescription and non-prescription medicines, vitamins, and herbal supplements.

Oestrogel Usage

Take estradiol exactly as prescribed.

 

Topical:

This medication is available as a vaginal cream, a transdermal patch, a transdermal gel, a transdermal spray, and vaginal insert. It is usually applied once a day.

 

Oral:

This medication is available as an oral tablet. It is usually taken once a day, with food.

 

Injectable:

This medication is also available in an injectable form to be given directly into a muscle (IM) by a healthcare professional.

 

If you miss a dose, take the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and take your next dose at the regular time. Do not take two doses of estradiol at the same time.

Oestrogel Overdose

If you take too much estradiol, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If estradiol is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Other Requirements

Store estradiol at room temperature.

Keep this and all medicines out of the reach of children.

Oestrogel FDA Warning

WARNING: ESTROGENS INCREASE THE RISK OF ENDOMETRIAL CANCER.CLOSE CLINICAL SURVEILLANCE OF ALL WOMEN TAKING ESTROGENS IS IMPORTANT. ADEQUATE DIAGNOSTIC MEASURES, INCLUDING ENDOMETRIAL SAMPLING WHEN INDICATED, SHOULD BE UNDERTAKEN TO RULE OUT MALIGNANCY IN ALL CASES OF UNDIAGNOSED PERSISTENT OR RECURRING ABNORMAL VAGINAL BLEEDING. THERE IS CURRENTLY NO EVIDENCE THAT THE USE OF “NATURAL” ESTROGENS RESULTS IN A DIFFERENT ENDOMETRIAL RISK PROFILE THAN SYNTHETIC ESTROGENS OF EQUIVALENT ESTROGEN DOSE.

CARDIOVASCULAR AND OTHER RISKS 

ESTROGENS WITH AND WITHOUT PROGESTINS SHOULD NOT BE USED FOR THE PREVENTION OF CARDIOVASCULAR DISEASE OR DEMENTIA.

THE WOMEN’S HEALTH INITIATIVE (WHI) STUDY REPORTED INCREASED RISKS OF MYOCARDIAL INFARCTION, STROKE, INVASIVE BREAST CANCER, PULMONARY EMBOLI, AND DEEP VEIN THROMBOSIS IN POSTMENOPAUSAL WOMEN (50 TO 79 YEARS OF AGE) DURING 5 YEARS OF TREATMENT WITH ORAL CONJUGATED ESTROGENS (CE 0.625 MG) COMBINED WITH MEDROXYPROGESTERONE ACETATE (MPA 2.5 MG) RELATIVE TO PLACEBO.

THE WOMEN’S HEALTH INITIATIVE MEMORY STUDY (WHIMS), A SUBSTUDY OF WHI, REPORTED INCREASED RISK OF DEVELOPING PROBABLE DEMENTIA IN POSTMENOPAUSAL WOMEN 65 YEARS OF AGE OR OLDER DURING 4 YEARS OF TREATMENT WITH ORAL CONJUGATED ESTROGENS PLUS MEDROXYPROGESTERONE ACETATE RELATIVE TO PLACEBO. IT IS UNKNOWN WHETHER THIS FINDING APPLIES TO YOUNGER POSTMENOPAUSAL WOMEN.

OTHER DOSES OF ORAL CONJUGATED ESTROGENS WITH MEDROXYPROGESTERONE ACETATE, AND OTHER COMBINATIONS AND DOSAGE FORMS OF ESTROGENS AND PROGESTINS WERE NOT STUDIED IN THE WHI CLINICAL TRIALS AND, IN THE ABSENCE OF COMPARABLE DATA, THESE RISKS SHOULD BE ASSUMED TO BE SIMILAR. BECAUSE OF THESE RISKS, ESTROGENS WITH OR WITHOUT PROGESTINS SHOULD BE PRESCRIBED AT THE LOWEST EFFECTIVE DOSES AND FOR THE SHORTEST DURATION CONSISTENT WITH TREATMENT GOALS AND RISKS FOR THE INDIVIDUAL WOMAN.

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