Nuquin HP Cream

Each gram of NUQUIN® HP 4% CREAM contains ACTIVES: 40mg Hydroquinone USP, 80mg of Padimate O, 30mg of Dioxybenzone and 20mg of Oxybenzone in a cream base of INACTIVES: Cetostearyl Alcohol, Glycerine, Mineral Oil, Polysorbate-60, Propylene Glycol, Purified Water, Sodium Lauryl Sulfate, Sodium Metabisulfite, Sorbic Acid and White Petrolatum.

Hydroquinone is 1, 4-Benzenediol. Hydroquinone is structurally related to monobenzone. Hydroquinone occurs as fine, white needles. The drug is freely soluble in water and in alcohol and has a pKa of 9.96. Chemically, hydroquinone is designated as p-dihydroxybenzene; the empirical formula is C6H6O2 and has a molecular weight of 110.11.

The structural formula is:

C6H602

Topical application of hydroquinone produces a reversible depigmentation of the skin by the inhibition of the enzymatic oxidation of tyrosine to 3, 4-dihydroxyphenylalanine (dopa) [Denton, C., et al., 19521] and suppression of other melanocyte metabolic processes [Jimbow, K., et al., 19742]. Exposure to sunlight or ultraviolet light will cause repigmentation of the bleached areas [Parrish, J.A. et al., 1978].

No systemic adverse reactions have been reported. Occasional hypersensitivity (localized contact dermatitis) may occur in which case the medication should be discontinued and the physician notified immediately.

There have been no systemic reactions reported from the use of topical hydroquinone treatment. However, treatment should be limited to relatively small areas of the body at one time since some patients may experience a transient skin reddening and a mild burning sensation which does not preclude treatment.

1. Denton, C., Lerner, A., and Fitzpatrick, T., "Inhibition of Melanin Formation by Chemical Agents", J. Invest. Derm., 18:119-135, 1952.

2. Jimbow, K., Obata, M., Pathak, M., and Fitzpatrick, T., "Mechanisms of Depigmentation by Hydroquinone", J. Invest. Derm., 62:436-449, 1974.

3. Parrish, J, Anderson, R., Urbach, F., and Pitts, D., " Biological Effects of Ultraviolet Radiation with Emphasis on Human Responses to Longwave Ultraviolet", Plenum Press, New York, 1978 (page 151).

NDC 58980-574-10
Net WT. 1 OZ (28.4g)

NUQUIN® HP 4% CREAM

STRATUS
PHARMACEUTICALS INC

(HYDROQUINONE USP, 4%)
SKIN BLEACHING CREAM WITH SUNSCREENS

Rx only

Distributed by Stratus Pharmaceuticals Inc., 12379 SW 130th Street, Miami, Florida 33186