Notuss-NXD

Name: Notuss-NXD

What happens if I miss a dose?

Since this medicine is taken when needed, you may not be on a dosing schedule. If you are taking the medication regularly, take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

What should I avoid while taking Notuss-NXD (chlorcyclizine, codeine, and pseudoephedrine)?

This medicine may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.

Do not drink alcohol while you are taking medicine that contains codeine. Dangerous side effects or death could occur.

Ask a doctor or pharmacist before using any other cold, allergy, cough, or sleep medicine. Many combination medicines contain antihistamines, decongestants, or cough suppressants. Taking certain products together can cause you to get too much of a certain drug.

Before Using Notuss-NXD

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Very young children are usually more sensitive to the effects of this medicine. Before giving any of these combination medicines to a child, check the package label very carefully. Some of these medicines are too strong for use in children. If you are not certain whether a specific product can be given to a child, or if you have any questions about the amount to give, check with your health care professional, especially if it contains:

  • Antihistamines—Nightmares, unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in children taking antihistamines.
  • Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Increases in blood pressure may be more likely to occur in children taking decongestants.
  • Iodides (e.g., calcium iodide and iodinated glycerol)—These medicines pass into the breast milk and may cause unwanted effects, such as underactive thyroid, in the baby.
  • Narcotic antitussives (e.g., codeine, dihydrocodeine, hydrocodone, and hydromorphone)—Breathing problems may be especially likely to occur in children younger than 2 years of age taking narcotic antitussives. Also, unusual excitement or restlessness may be more likely to occur in children receiving these medicines.
  • Salicylates (e.g., aspirin)—Do not give medicines containing aspirin or other salicylates to a child or teenager with a fever or other symptoms of a virus infection, especially flu or chickenpox, without first discussing its use with your child's doctor. This is very important because salicylates may cause a serious illness called Reye's syndrome in children with fever caused by a virus infection, especially flu or chickenpox. Also, children may be more sensitive to the aspirin or other salicylates contained in some of these medicines, especially if they have a fever or have lost large amounts of body fluid because of vomiting, diarrhea, or sweating.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

Geriatric

The elderly are usually more sensitive to the effects of this medicine, especially if it contains:

  • Antihistamines—Confusion, difficult or painful urination, dizziness, drowsiness, feeling faint, or dryness of mouth, nose, or throat may be more likely to occur in elderly patients. Also, nightmares or unusual excitement, nervousness, restlessness, or irritability may be more likely to occur in the elderly taking antihistamines.
  • Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Confusion, hallucinations, drowsiness, or convulsions (seizures) may be more likely to occur in the elderly, who are usually more sensitive to the effects of this medicine. Also, increases in blood pressure may be more likely to occur in elderly persons taking decongestants.

Pregnancy

The occasional use of a cough/cold combination is not likely to cause problems in the fetus or in the newborn baby. However, when these medicines are used at higher doses and/or for a long time, the chance that problems might occur may increase. For the individual ingredients of these combinations, the following information should be considered before you decide to use a particular cough/cold combination:

  • Acetaminophen—Studies on birth defects have not been done in humans. However, acetaminophen has not been shown to cause birth defects or other problems in humans.
  • Alcohol—Some of these combination medicines contain a large amount of alcohol. Too much use of alcohol during pregnancy may cause birth defects.
  • Antihistamines—Antihistamines have not been shown to cause problems in humans.
  • Caffeine—Studies in humans have not shown that caffeine causes birth defects. However, studies in animals have shown that caffeine causes birth defects when given in very large doses (amounts equal to the amount of caffeine contained in 12 to 24 cups of coffee a day).
  • Codeine—Although studies on birth defects with codeine have not been done in humans, it has not been reported to cause birth defects in humans. Codeine has not been shown to cause birth defects in animal studies, but it caused other unwanted effects. Also, regular use of narcotics during pregnancy may cause the baby to become dependent on the medicine. This may lead to withdrawal side effects after birth. In addition, narcotics may cause breathing problems in the newborn baby if taken by the mother just before delivery.
  • Hydrocodone—Although studies on birth defects with hydrocodone have not been done in humans, it has not been reported to cause birth defects in humans. However, hydrocodone has been shown to cause birth defects in animals when given in very large doses. Also, regular use of narcotics during pregnancy may cause the baby to become dependent on the medicine. This may lead to withdrawal side effects after birth. In addition, narcotics may cause breathing problems in the newborn baby if taken by the mother just before delivery.
  • Iodides (e.g., calcium iodide and iodinated glycerol)—Not recommended during pregnancy. Iodides have caused enlargement of the thyroid gland in the fetus and resulted in breathing problems in newborn babies whose mothers took iodides in large doses for a long period of time.
  • Phenylephrine—Studies on birth defects with phenylephrine have not been done in either humans or animals.
  • Pseudoephedrine—Studies on birth defects with pseudoephedrine have not been done in humans. In animal studies pseudoephedrine did not cause birth defects but did cause a decrease in average weight, length, and rate of bone formation in the animal fetus when given in high doses.
  • Salicylates (e.g., aspirin)—Studies on birth defects in humans have been done with aspirin, but not with salicylamide or sodium salicylate. Salicylates have not been shown to cause birth defects in humans. However, salicylates have been shown to cause birth defects in animals.

Some reports have suggested that too much use of aspirin late in pregnancy may cause a decrease in the newborn's weight and possible death of the fetus or newborn infant. However, the mothers in these reports had been taking much larger amounts of aspirin than are usually recommended. Studies of mothers taking aspirin in the doses that are usually recommended did not show these unwanted effects. However, there is a chance that regular use of salicylates late in pregnancy may cause unwanted effects on the heart or blood flow in the fetus or newborn baby.

Use of salicylates, especially aspirin, during the last 2 weeks of pregnancy may cause bleeding problems in the fetus before or during delivery, or in the newborn baby. Also, too much use of salicylates during the last 3 months of pregnancy may increase the length of pregnancy, prolong labor, cause other problems during delivery, or cause severe bleeding in the mother before, during, or after delivery. Do not take aspirin during the last 3 months of pregnancy unless it has been ordered by your doctor.

Breast Feeding

If you are breastfeeding, the chance that problems might occur depends on the ingredients of the combination. For the individual ingredients of these combinations, the following apply:

  • Acetaminophen—Acetaminophen passes into the breast milk. However, it has not been reported to cause problems in nursing babies.
  • Alcohol—Alcohol passes into the breast milk. However, the amount of alcohol in recommended doses of this medicine does not usually cause problems in nursing babies.
  • Antihistamines—Small amounts of antihistamines pass into the breast milk. Antihistamine-containing medicine is not recommended for use while breastfeeding since most antihistamines are especially likely to cause side effects, such as unusual excitement or irritability, in the baby. Also, since antihistamines tend to decrease the secretions of the body, the flow of breast milk may be reduced in some patients.
  • Caffeine—Small amounts of caffeine pass into the breast milk and may build up in the nursing baby. However, the amount of caffeine in recommended doses of this medicine does not usually cause problems in nursing babies.
  • Codeine and other narcotic cough medicines (e.g., dihydrocodeine, hydrocodone, and hydromorphone)—Codeine is changed to morphine in the body. Some people change codeine to morphine more quickly than others. These individuals are called "ultra-rapid metabolizers of codeine". If a nursing mother is an ultra-rapid metabolizer of codeine, it could lead to a morphine overdose in the nursing baby and cause very serious side effects. A nursing mother should talk to her doctor if she has any questions about taking codeine or about how this medicine may affect her baby .
  • Decongestants (e.g., ephedrine, phenylephrine, pseudoephedrine—Phenylephrine has not been reported to cause problems in nursing babies. Ephedrine and pseudoephedrine pass into the breast milk and may cause unwanted effects in nursing babies (especially newborn and premature babies).
  • Iodides (e.g., calcium iodide and iodinated glycerol)—These medicines pass into the breast milk and may cause unwanted effects, such as underactive thyroid, in the baby.
  • Salicylates (e.g., aspirin)—Salicylates pass into the breast milk. Although salicylates have not been reported to cause problems in nursing babies, it is possible that problems may occur if large amounts are taken regularly.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using medicines in this class with any of the following medicines is not recommended. Your doctor may decide not to treat you with a medication in this class or change some of the other medicines you take.

  • Alfuzosin
  • Amifampridine
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amprenavir
  • Anagrelide
  • Apomorphine
  • Aripiprazole
  • Aripiprazole Lauroxil
  • Arsenic Trioxide
  • Artemether
  • Asenapine
  • Astemizole
  • Atazanavir
  • Azithromycin
  • Bedaquiline
  • Bepridil
  • Boceprevir
  • Buserelin
  • Chloroquine
  • Chlorpromazine
  • Ciprofloxacin
  • Cisapride
  • Citalopram
  • Clarithromycin
  • Clomipramine
  • Clorgyline
  • Clozapine
  • Cobicistat
  • Crizotinib
  • Cyclobenzaprine
  • Cyclopropane
  • Dabrafenib
  • Darunavir
  • Dasabuvir
  • Defibrotide
  • Degarelix
  • Delamanid
  • Delavirdine
  • Desipramine
  • Deslorelin
  • Deutetrabenazine
  • Dichlorphenamide
  • Dihydroergotamine
  • Disopyramide
  • Dofetilide
  • Dolasetron
  • Domperidone
  • Donepezil
  • Doxepin
  • Dronedarone
  • Droperidol
  • Ebastine
  • Efavirenz
  • Elvitegravir
  • Eribulin
  • Erythromycin
  • Escitalopram
  • Famotidine
  • Felbamate
  • Fingolimod
  • Flecainide
  • Fluconazole
  • Fluoxetine
  • Fluvoxamine
  • Formoterol
  • Foscarnet
  • Fosphenytoin
  • Furazolidone
  • Galantamine
  • Gatifloxacin
  • Gemifloxacin
  • Gonadorelin
  • Goserelin
  • Granisetron
  • Halofantrine
  • Haloperidol
  • Halothane
  • Histrelin
  • Hydroquinidine
  • Hydroxychloroquine
  • Hydroxyzine
  • Ibutilide
  • Iloperidone
  • Imipramine
  • Indinavir
  • Influenza Virus Vaccine, Live
  • Iproniazid
  • Isocarboxazid
  • Itraconazole
  • Ivabradine
  • Ketoconazole
  • Ketorolac
  • Lapatinib
  • Leuprolide
  • Levofloxacin
  • Levomethadyl
  • Linezolid
  • Lumefantrine
  • Mefloquine
  • Mesoridazine
  • Methadone
  • Methotrimeprazine
  • Methylene Blue
  • Metronidazole
  • Mifepristone
  • Mizolastine
  • Moclobemide
  • Moricizine
  • Moxifloxacin
  • Nafarelin
  • Nalmefene
  • Naltrexone
  • Nefazodone
  • Nelfinavir
  • Nialamide
  • Nilotinib
  • Norfloxacin
  • Octreotide
  • Ofloxacin
  • Olanzapine
  • Ombitasvir
  • Ondansetron
  • Paliperidone
  • Panobinostat
  • Papaverine
  • Pargyline
  • Paritaprevir
  • Paroxetine
  • Pasireotide
  • Pazopanib
  • Pentamidine
  • Perphenazine
  • Phenelzine
  • Pimavanserin
  • Pimozide
  • Pipamperone
  • Piperaquine
  • Pitolisant
  • Posaconazole
  • Potassium
  • Probucol
  • Procainamide
  • Procarbazine
  • Prochlorperazine
  • Promethazine
  • Propafenone
  • Protriptyline
  • Quetiapine
  • Quinidine
  • Quinine
  • Ranolazine
  • Rasagiline
  • Ribociclib
  • Rilpivirine
  • Riociguat
  • Risperidone
  • Ritonavir
  • Safinamide
  • Saquinavir
  • Selegiline
  • Sertindole
  • Sevoflurane
  • Sibutramine
  • Sodium Oxybate
  • Sodium Phosphate
  • Sodium Phosphate, Dibasic
  • Sodium Phosphate, Monobasic
  • Solifenacin
  • Sorafenib
  • Sotalol
  • Sparfloxacin
  • Sulpiride
  • Sultopride
  • Sunitinib
  • Tacrolimus
  • Tamoxifen
  • Telaprevir
  • Telavancin
  • Telithromycin
  • Tetrabenazine
  • Thioridazine
  • Tipranavir
  • Tizanidine
  • Toloxatone
  • Tolterodine
  • Toremifene
  • Tranylcypromine
  • Trazodone
  • Trimipramine
  • Triptorelin
  • Vandetanib
  • Vardenafil
  • Vemurafenib
  • Venlafaxine
  • Vilanterol
  • Vinflunine
  • Voriconazole
  • Vorinostat
  • Ziprasidone
  • Zolmitriptan
  • Zotepine
  • Zuclopenthixol

Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

  • Abciximab
  • Acarbose
  • Aceclofenac
  • Acemetacin
  • Acenocoumarol
  • Acepromazine
  • Acetyldigoxin
  • Adenosine
  • Alefacept
  • Alfentanil
  • Alipogene Tiparvovec
  • Almotriptan
  • Alprazolam
  • Alteplase, Recombinant
  • Amiloride
  • Amineptine
  • Amiodarone
  • Amisulpride
  • Amitriptyline
  • Amitriptylinoxide
  • Amobarbital
  • Amoxapine
  • Amphetamine
  • Amtolmetin Guacil
  • Amygdalin
  • Anagrelide
  • Ancrod
  • Anileridine
  • Anisindione
  • Antithrombin III Human
  • Apixaban
  • Aprepitant
  • Aprobarbital
  • Ardeparin
  • Argatroban
  • Aripiprazole
  • Arsenic Trioxide
  • Asenapine
  • Aspirin
  • Atazanavir
  • Axitinib
  • Baclofen
  • Balsalazide
  • Bemiparin
  • Bendroflumethiazide
  • Benperidol
  • Benzphetamine
  • Benzthiazide
  • Betamethasone
  • Betrixaban
  • Bismuth Subsalicylate
  • Bivalirudin
  • Blinatumomab
  • Boceprevir
  • Bosutinib
  • Bromazepam
  • Bromfenac
  • Bromocriptine
  • Bromopride
  • Brompheniramine
  • Bucindolol
  • Budesonide
  • Bufexamac
  • Bumetanide
  • Buprenorphine
  • Bupropion
  • Buspirone
  • Butabarbital
  • Butalbital
  • Butorphanol
  • Calcifediol
  • Cangrelor
  • Carbamazepine
  • Carbinoxamine
  • Carisoprodol
  • Carmustine
  • Carphenazine
  • Carteolol
  • Carvedilol
  • Celecoxib
  • Ceritinib
  • Certoparin
  • Chloral Hydrate
  • Chlordiazepoxide
  • Chlorothiazide
  • Chlorpheniramine
  • Chlorpromazine
  • Chlorpropamide
  • Chlorthalidone
  • Chlorzoxazone
  • Choline Magnesium Trisalicylate
  • Choline Salicylate
  • Cilostazol
  • Cimetidine
  • Ciprofloxacin
  • Citalopram
  • Clarithromycin
  • Clobazam
  • Clomipramine
  • Clonazepam
  • Clonixin
  • Clopamide
  • Clopidogrel
  • Clorazepate
  • Clorgyline
  • Clozapine
  • Cobimetinib
  • Cocaine
  • Codeine
  • Conivaptan
  • Cortisone
  • Cyclobenzaprine
  • Cyclopenthiazide
  • Cyclosporine
  • Dabigatran Etexilate
  • Daclatasvir
  • Dalteparin
  • Danaparoid
  • Dantrolene
  • Darunavir
  • Dasabuvir
  • Deferasirox
  • Deferoxamine
  • Defibrotide
  • Deflazacort
  • Delavirdine
  • Dermatan Sulfate
  • Desipramine
  • Desirudin
  • Deslanoside
  • Desmopressin
  • Desogestrel
  • Desvenlafaxine
  • Dexamethasone
  • Dexibuprofen
  • Dexketoprofen
  • Dexmedetomidine
  • Dextroamphetamine
  • Dextromethorphan
  • Dezocine
  • Diacetylmorphine
  • Diazepam
  • Diazoxide
  • Dibenzepin
  • Dichloralphenazone
  • Diclofenac
  • Dicumarol
  • Dienogest
  • Difenoxin
  • Diflunisal
  • Digitalis
  • Digitoxin
  • Digoxin
  • Dihydroartemisinin
  • Dihydrocodeine
  • Dilevalol
  • Diltiazem
  • Diphenhydramine
  • Diphenoxylate
  • Dipyridamole
  • Dipyrone
  • Dolasetron
  • Domperidone
  • Donepezil
  • Dothiepin
  • Doxepin
  • Doxorubicin
  • Doxorubicin Hydrochloride Liposome
  • Doxylamine
  • Dronedarone
  • Droperidol
  • Drospirenone
  • Droxicam
  • Duloxetine
  • Edoxaban
  • Elbasvir
  • Eletriptan
  • Eliglustat
  • Enflurane
  • Enoxacin
  • Enoxaparin
  • Entacapone
  • Eplerenone
  • Epoprostenol
  • Eptifibatide
  • Ergonovine
  • Erlotinib
  • Erythromycin
  • Escitalopram
  • Eslicarbazepine Acetate
  • Estazolam
  • Estradiol Cypionate
  • Estradiol Valerate
  • Eszopiclone
  • Ethacrynic Acid
  • Ethchlorvynol
  • Ethinyl Estradiol
  • Ethopropazine
  • Ethylmorphine
  • Ethynodiol Diacetate
  • Etintidine
  • Etodolac
  • Etofenamate
  • Etonogestrel
  • Etoricoxib
  • Etravirine
  • Felbinac
  • Fenoprofen
  • Fentanyl
  • Fepradinol
  • Feprazone
  • Feverfew
  • Flibanserin
  • Floctafenine
  • Fluconazole
  • Flufenamic Acid
  • Flunitrazepam
  • Fluocortolone
  • Fluoxetine
  • Fluphenazine
  • Flurazepam
  • Flurbiprofen
  • Fluspirilene
  • Fluvoxamine
  • Fondaparinux
  • Fosaprepitant
  • Fosphenytoin
  • Fospropofol
  • Frovatriptan
  • Furazolidone
  • Furosemide
  • Ginkgo
  • Glimepiride
  • Glipizide
  • Glyburide
  • Golimumab
  • Gossypol
  • Granisetron
  • Grazoprevir
  • Guanethidine
  • Guselkumab
  • Halazepam
  • Haloperidol
  • Halothane
  • Heparin
  • Hexobarbital
  • Hyaluronidase
  • Hydrochlorothiazide
  • Hydrocodone
  • Hydrocortisone
  • Hydroflumethiazide
  • Hydromorphone
  • Hydroxytryptophan
  • Hydroxyzine
  • Ibuprofen
  • Idelalisib
  • Idrocilamide
  • Ifosfamide
  • Iloprost
  • Imatinib
  • Imipenem
  • Imipramine
  • Indapamide
  • Indinavir
  • Indomethacin
  • Iobenguane I 123
  • Iproniazid
  • Isocarboxazid
  • Isoflurane
  • Isoniazid
  • Itraconazole
  • Ketamine
  • Ketazolam
  • Ketobemidone
  • Ketoconazole
  • Ketoprofen
  • Lanreotide
  • Ledipasvir
  • Lepirudin
  • Levalbuterol
  • Levobunolol
  • Levofloxacin
  • Levomilnacipran
  • Levonorgestrel
  • Levorphanol
  • Licorice
  • Linezolid
  • Lisdexamfetamine
  • Lithium
  • Lofepramine
  • Lopinavir
  • Lorazepam
  • Lorcaserin
  • Lormetazepam
  • Lornoxicam
  • Loxapine
  • Loxoprofen
  • Lumiracoxib
  • Magnesium Salicylate
  • Meadowsweet
  • Meclizine
  • Meclofenamate
  • Medazepam
  • Medroxyprogesterone Acetate
  • Mefenamic Acid
  • Melitracen
  • Meloxicam
  • Melperone
  • Memantine
  • Meperidine
  • Mephenesin
  • Mephobarbital
  • Meprobamate
  • Meptazinol
  • Mesalamine
  • Mesoridazine
  • Mestranol
  • Metaxalone
  • Metformin
  • Methadone
  • Methamphetamine
  • Methdilazine
  • Methocarbamol
  • Methohexital
  • Methotrexate
  • Methotrimeprazine
  • Methoxyflurane
  • Methyclothiazide
  • Methyldopa
  • Methylene Blue
  • Methylergonovine
  • Methylprednisolone
  • Metildigoxin
  • Metipranolol
  • Metolazone
  • Mexiletine
  • Midazolam
  • Midodrine
  • Mifepristone
  • Milnacipran
  • Mirtazapine
  • Moclobemide
  • Molindone
  • Moricizine
  • Morniflumate
  • Morphine
  • Morphine Sulfate Liposome
  • Nabumetone
  • Nadolol
  • Nadroparin
  • Nalbuphine
  • Naproxen
  • Naratriptan
  • Nateglinide
  • Nefazodone
  • Nelfinavir
  • Nepafenac
  • Netupitant
  • Nialamide
  • Nicomorphine
  • Nicorandil
  • Nifedipine
  • Niflumic Acid
  • Nimesulide
  • Nimesulide Beta Cyclodextrin
  • Nimodipine
  • Nitrazepam
  • Nitrous Oxide
  • Norelgestromin
  • Norethindrone
  • Norgestimate
  • Norgestrel
  • Nortriptyline
  • Olanzapine
  • Olaparib
  • Olsalazine
  • Ombitasvir
  • Ondansetron
  • Opipramol
  • Opium
  • Opium Alkaloids
  • Orlistat
  • Orphenadrine
  • Oxaprozin
  • Oxazepam
  • Oxprenolol
  • Oxycodone
  • Oxymorphone
  • Oxyphenbutazone
  • Oxytocin
  • Palonosetron
  • Panobinostat
  • Papaveretum
  • Paramethasone
  • Parecoxib
  • Paregoric
  • Pargyline
  • Paritaprevir
  • Parnaparin
  • Paroxetine
  • Pefloxacin
  • Peginterferon Alfa-2a
  • Peginterferon Alfa-2b
  • Pemetrexed
  • Penbutolol
  • Pentazocine
  • Pentobarbital
  • Pentosan Polysulfate Sodium
  • Pentoxifylline
  • Perampanel
  • Perazine
  • Periciazine
  • Perphenazine
  • Phenelzine
  • Phenindione
  • Phenobarbital
  • Phenprocoumon
  • Phenylbutazone
  • Phenyl Salicylate
  • Phenytoin
  • Piketoprofen
  • Pimozide
  • Pindolol
  • Piperacetazine
  • Piperaquine
  • Pipotiazine
  • Piracetam
  • Piritramide
  • Piroxicam
  • Pixantrone
  • Pneumococcal 13-Valent Vaccine, Diphtheria Conjugate
  • Polythiazide
  • Posaconazole
  • Pralatrexate
  • Pranoprofen
  • Prasugrel
  • Prazepam
  • Prednisolone
  • Prednisone
  • Primidone
  • Procarbazine
  • Prochlorperazine
  • Proglumetacin
  • Promazine
  • Promethazine
  • Propofol
  • Propranolol
  • Propyphenazone
  • Proquazone
  • Protein C
  • Protriptyline
  • Quazepam
  • Quetiapine
  • Ramelteon
  • Rasagiline
  • Reboxetine
  • Regadenoson
  • Remifentanil
  • Remoxipride
  • Repaglinide
  • Reteplase, Recombinant
  • Reviparin
  • Ritonavir
  • Rivaroxaban
  • Rizatriptan
  • Rofecoxib
  • Salicylamide
  • Salicylic Acid
  • Salsalate
  • Saquinavir
  • Secobarbital
  • Secukinumab
  • Selegiline
  • Sertindole
  • Sertraline
  • Sibutramine
  • Simeprevir
  • Sirolimus
  • Sodium Oxybate
  • Sodium Salicylate
  • Sonidegib
  • Sotalol
  • Spironolactone
  • St John's Wort
  • Sufentanil
  • Sulfasalazine
  • Sulindac
  • Sulpiride
  • Sumatriptan
  • Sunitinib
  • Suvorexant
  • Tacrolimus
  • Tapentadol
  • Telaprevir
  • Telithromycin
  • Temazepam
  • Teniposide
  • Tenofovir Alafenamide
  • Tenoxicam
  • Tertatolol
  • Thiabendazole
  • Thiethylperazine
  • Thiopental
  • Thiopropazate
  • Thioridazine
  • Tianeptine
  • Tiaprofenic Acid
  • Ticagrelor
  • Ticlopidine
  • Tilidine
  • Timolol
  • Tinzaparin
  • Tiotropium
  • Tirofiban
  • Tizanidine
  • Tolazamide
  • Tolbutamide
  • Tolfenamic Acid
  • Tolmetin
  • Tolonium Chloride
  • Tolvaptan
  • Topiramate
  • Torsemide
  • Tramadol
  • Tranylcypromine
  • Trazodone
  • Treprostinil
  • Triamterene
  • Triazolam
  • Trichlormethiazide
  • Trifluoperazine
  • Trifluperidol
  • Triflupromazine
  • Trimeprazine
  • Trimipramine
  • Trolamine Salicylate
  • Troleandomycin
  • Tryptophan
  • Ulipristal
  • Valdecoxib
  • Varicella Virus Vaccine
  • Velpatasvir
  • Vemurafenib
  • Venetoclax
  • Venlafaxine
  • Verapamil
  • Vilazodone
  • Vorapaxar
  • Voriconazole
  • Vortioxetine
  • Warfarin
  • Xipamide
  • Zaleplon
  • Zileuton
  • Ziprasidone
  • Zolmitriptan
  • Zolpidem
  • Zopiclone
  • Zotepine

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Using medicines in this class with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use your medicine, or give you special instructions about the use of food, alcohol, or tobacco.

  • Ethanol
  • Grapefruit Juice
  • Tobacco

Other Medical Problems

The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:

  • Alcohol abuse (or history of)—Acetaminophen-containing medicines increase the chance of liver damage; also, some of the liquid medicines contain a large amount of alcohol.
  • Anemia or
  • Gout or
  • Hemophilia or other bleeding problems or
  • Stomach ulcer or other stomach problems—These conditions may become worse if you are taking a combination medicine containing aspirin or another salicylate.
  • Brain disease or injury or
  • Colitis or
  • Convulsions (seizures) (history of) or
  • Diarrhea or
  • Gallbladder disease or gallstones—These conditions may become worse if you are taking a combination medicine containing codeine, dihydrocodeine, hydrocodone, or hydromorphone
  • Cystic fibrosis (in children)—Side effects of iodinated glycerol may be more likely in children with cystic fibrosis.
  • Diabetes mellitus (sugar diabetes)—Decongestants may put diabetic patients at greater risk of having heart or blood vessel disease.
  • Emphysema, asthma, or chronic lung disease (especially in children)—Salicylate-containing medicine may cause an allergic reaction in which breathing becomes difficult.
  • Enlarged prostate or
  • Urinary tract blockage or difficult urination—Some of the effects of anticholinergics (e.g., homatropine) or antihistamines may make urinary problems worse.
  • Glaucoma—A slight increase in inner eye pressure may occur with the use of anticholinergics (e.g., homatropine) or antihistamines, which may make the condition worse.
  • Heart or blood vessel disease or
  • High blood pressure—Decongestant-containing medicine may increase the blood pressure and speed up the heart rate; also, caffeine-containing medicine, if taken in large amounts, may speed up the heart rate.
  • Kidney disease—This condition may increase the chance of side effects of this medicine because the medicine may build up in the body.
  • Liver disease—Liver disease increases the chance of side effects because the medicine may build up in the body; also, if liver disease is severe, there is a greater chance that aspirin-containing medicine may cause bleeding.
  • Thyroid disease—If an overactive thyroid has caused a fast heart rate, the decongestant in this medicine may cause the heart rate to speed up further; also, if the medicine contains narcotic antitussives (e.g., codeine), iodides (e.g., iodinated glycerol), or salicylates, the thyroid problem may become worse.

Proper Use of cough and cold combinations

This section provides information on the proper use of a number of products that contain cough and cold combinations. It may not be specific to Notuss-NXD. Please read with care.

To help loosen mucus or phlegm in the lungs, drink a glass of water after each dose of this medicine, unless otherwise directed by your doctor.

Take this medicine only as directed. Do not take more of it and do not take it more often than recommended on the label, unless otherwise directed by your doctor. To do so may increase the chance of side effects.

Do not give any over-the-counter (OTC) cough and cold medicine to a baby or child under 4 years of age. Using these medicines in very young children might cause serious or possibly life-threatening side effects .

For patients taking the extended-release capsule or tablet form of this medicine:

  • Swallow the capsule or tablet whole.
  • Do not crush, break, or chew before swallowing.
  • If the capsule is too large to swallow, you may mix the contents of the capsule with applesauce, jelly, honey, or syrup and swallow without chewing.

For patients taking the extended-release oral solution or oral suspension form of this medicine:

  • Do not dilute with fluids or mix with other drugs.

For patients taking a combination medicine containing an antihistamine and/or aspirin or other salicylate:

  • Take with food or a glass of water or milk to lessen stomach irritation, if necessary.

If a combination medicine containing aspirin has a strong vinegar-like odor, do not use it. This odor means the medicine is breaking down. If you have any questions about this, check with your pharmacist.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not keep outdated medicine or medicine no longer needed.

Keep the liquid form of this medicine from freezing. Do not refrigerate the syrup.

Description

Each 5 mL (one teaspoonful) for oral administration contains:
Codeine Phosphate .................................................. 10 mg
(WARNING: May be habit forming)
Pseudoephedrine HCl .............................................. 30 mg
Chlorcyclizine HCl ............................................... 9.375 mg

Active Ingredients                                                    Purpose
(in each 5 mL teaspoonful)
Codeine Phosphate 10 mg .................................. Antitussive
Pseudoephedrine Hydrochloride 30 mg ........... Decongestant
Chlorcyclizine Hydrochloride 9.375 mg .............. Antihistamine

Uses


Temporarily relieves these symptoms due to the common cold, hay fever (allergic rhinitis) or other upper respiratory allergies:
- runny nose - sneezing - itching of the nose or throat - itchy, watery eyes - cough due to minor throat and bronchial irritation - nasal congestion - reduces swelling of the nasal passages

For Healthcare Professionals

Applies to chlorcyclizine / codeine / pseudoephedrine: oral liquid

General

The most common side effects may include drowsiness, dizziness, dry mouth, and nervousness.[Ref]

Respiratory

Frequency not reported: Respiratory depression

Psychiatric

Frequency not reported: Excitability, nervousness, insomnia

Nervous system

Frequency not reported: Drowsiness[Ref]

Cardiovascular

Frequency not reported: Hypotension, dizziness[Ref]

Gastrointestinal

Frequency not reported: Nausea, vomiting, constipation , dry mouth[Ref]

Genitourinary

Frequency not reported: Urinary retention[Ref]

Ocular

Frequency not reported: Blurred vision[Ref]

Dermatologic

Frequency not reported: Rashes, severe scarlatiniform eruptions, generalized dermatitis[Ref]

Some side effects of Notuss-NXD may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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