Nitroglycerin Rectal Ointment

• If you have an allergy to nitroglycerin or any other part of nitroglycerin rectal ointment.
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have any of these health problems: Anemia, raised pressure in the head, or recent heart attack.
• If you are taking any of these drugs: Avanafil, riociguat, sildenafil, tadalafil, or vardenafil.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take nitroglycerin rectal ointment with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

Use nitroglycerin rectal ointment as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Wash your hands before and after use.
• Cover your finger with plastic-wrap, a surgical glove, or a finger cot.
• Use the dosing guide on the box to put the ointment on your covered finger.
• Place the finger with the ointment on it into the anal canal up to the first finger joint.
• Smear the ointment inside the anus.
• You may also put the ointment on the outside of your anus.
• Keep out of your mouth, nose, vagina, and eyes (may burn).

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

Dosage Information (comprehensive)

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

• Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
• Very bad dizziness or passing out.
• Very bad headache.
• Fast or slow heartbeat.
• Flushing.
• Blurred eyesight.
• Dry mouth.
• Sweating a lot.
• Pale skin.
• Very upset stomach or throwing up.
• A heartbeat that does not feel normal.
• Restlessness.
• Feeling very tired or weak.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Dizziness.
• You may have headaches when you start taking this medicine. Most of the time it gets better with time. Do not change how you use nitroglycerin rectal ointment to avoid these headaches. Talk with your doctor for ways to lessen this side effect.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

Side Effects (complete list)