Netupitant-palonosetron

Contraindications

None

Cautions

Hypersensitivity, including anaphylaxis, reported

Serotonin syndrome has been reported with 5-HT3 receptor antagonists (eg, palonosetron)

Netupitant is a CYP3A4 substrate and a moderate inhibitor of CYP3A4

Get emergency medical help if you have any of these signs of an allergic reaction: hives; chest pain, difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if you have:

• high levels of serotonin in the body--agitation, hallucinations, fever, fast heart rate, overactive reflexes, nausea, vomiting, diarrhea, loss of coordination, fainting.

Common side effects may include:

• upset stomach, constipation;
• headache;
• skin redness; or
• weakness, tired feeling.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Follow all directions on your prescription label. Do not use this medicine in larger or smaller amounts or for longer than recommended.

Netupitant and palonosetron is usually taken 1 hour before the start of chemotherapy. Follow your doctor's instructions.

You may take netupitant and palonosetron with or without food.

This medicine is given ahead of time and will not treat nausea or vomiting you already have.

Store at room temperature away from moisture and heat.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.

Netupitant/palonosetron is a prescription medication used to prevent nausea and vomiting in patients receiving cancer chemotherapy.

Netupitant/palonosetron is available in capsule form and is taken 1 hour before the start of chemotherapy. It can be taken with or without food.

This medication comes in a single capsule that contains two medications: netupitant and palonosetron. Palonosetron is a serotonin receptor antagonist. This drug prevents nausea and vomiting during the first 24 hours after the start of cancer chemotherapy. Netupitant is a substance P/neurokinin 1 receptor antagonist. This drug prevents nausea and vomiting during both the acute phase(first 24 hours) and delayed phase (from 25 to 120 hours) after the start of cancer chemotherapy.

Common side effects of netupitant/palonosetron include headache, weakness, fatigue, indigestion and constipation.

Netupitant/palonosetron can also cause dizziness. Do not drive or operate heavy machinery until you know how netupitant/palonosetron affects you.

Medications can interact with certain foods. In some cases, this may be harmful and your doctor may advise you to avoid certain foods. In the case of netupitant/palonosetron, there are no specific foods that you must exclude from your diet when receiving this medication.

Tell your doctor if you are breastfeeding or plan to breastfeed.

It is not known if netupitant/palonosetron crosses into human milk. Because many medications can cross into human milk and because of the possibility for serious adverse reactions in nursing infants with use of this medication, a choice should be made whether to stop nursing or stop the use of this medication. Your doctor and you will decide if the benefits outweigh the risk of using netupitant/palonosetron .

If you take too much netupitant/palonosetron, call your healthcare provider or local Poison Control Center or seek emergency medical attention right away.

If netupitant/palonosetron is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.