Neosar oral and injection

Cyclophosphamide is a cancer medication that interferes with the growth and spread of cancer cells in the body.

Cyclophosphamide is used to treat several types of cancer. Cyclophosphamide is also used to treat certain cases of nephrotic syndrome (kidney disease) in children.

Cyclophosphamide may also be used for purposes not listed in this medication guide.

You should not use cyclophosphamide if you are allergic to it, or if you have severe bone marrow suppression.

To make sure cyclophosphamide is safe for you, tell your doctor if you have:

• an active or recent infection;

• a weak immune system (caused by disease or by using certain medicines);

• heart disease;

• kidney disease;

• liver disease;

• if you are receiving other cancer treatments; or

• if you have ever received radiation treatment.

Using cyclophosphamide may increase your risk of developing other types of cancer, such as bladder cancer. Talk with your doctor about your specific risk.

Do not use cyclophosphamide if you are pregnant. It could harm the unborn baby. Use effective birth control, and tell your doctor if you become pregnant during treatment.

This medication may affect fertility (your ability to have children), whether you are a man or a woman.

Cyclophosphamide can pass into breast milk and may harm a nursing baby. You should not breast-feed while you are using this medication.

Take the missed oral dose as soon as you remember. If it is almost time for the next dose, skip the dose you missed and take only the next regularly scheduled dose as directed. Do not take a double dose of this medication.

Contact your doctor if you miss a dose of cyclophosphamide injection.

Tell your doctor about all medications you use, and those you start or stop using during your treatment with cyclophosphamide, especially:

• phenobarbital (Solfoton); or

• drugs that weaken the immune system such as medicines to treat psoriasis, rheumatoid arthritis, or other autoimmune disorders.

This list is not complete. Other drugs may interact with cyclophosphamide, including prescription, over-the-counter, vitamin, and herbal products. Not all possible interactions are listed in this medication guide.

Applies to cyclophosphamide: capsule, powder for solution, tablet

Along with its needed effects, cyclophosphamide (the active ingredient contained in Neosar) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking cyclophosphamide:

• Cough or hoarseness
• fever or chills
• lower back or side pain
• missing menstrual periods
• painful or difficult urination

• Blood in the urine
• dizziness, confusion, or agitation
• fast heartbeat
• joint pain
• shortness of breath
• swelling of the feet or lower legs
• unusual tiredness or weakness

• Black, tarry stools
• pinpoint red spots on the skin
• unusual bleeding or bruising

• Frequent urination
• redness, swelling, or pain at the injection site
• sores in the mouth and on the lips
• sudden shortness of breath
• unusual thirst
• yellow eyes or skin

Some side effects of cyclophosphamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Darkening of the skin and fingernails
• loss of appetite
• nausea or vomiting

• Diarrhea
• flushing or redness of the face
• headache
• increased sweating
• skin rash, hives, or itching
• stomach pain
• swollen lips