Naloxegol

This medication may be prescribed for other uses; ask your doctor or pharmacist for more information.

If you take too much naloxegol, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

If naloxegol is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. However, if overdose is suspected, seek emergency medical attention.

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

In the U.S.

• Movantik

Available Dosage Forms:

• Tablet

Pharmacologic Class: Opioid Antagonist

It is very important that your doctor check your progress at regular visits. This will allow your doctor to see if the medicine is working properly and to decide if you should continue to take it.

Do not take naloxegol together with clarithromycin, itraconazole, or ketoconazole. Using these medicines together may cause or worsen opioid withdrawal symptoms, such as anxiety, chills, diarrhea, irritability, stomach pain, sweating, and yawning.

Call your doctor right away if you have severe stomach pain or diarrhea while you are using naloxegol.

naloxegol may cause a tear (perforation) in your stomach or bowels. Check with your doctor right away if you have a severe stomach pain that does not go away.

Do not take other medicines unless they have been discussed with your doctor. This includes prescription or nonprescription (over-the-counter [OTC]) medicines and herbal (eg, St. John's wort) or vitamin supplements.

Use this medicine as ordered by your doctor. Read all information given to you. Follow all instructions closely.

• Take on an empty stomach. Take at least 1 hour before or 2 hours after the first meal of the day.
• If you are not able to swallow naloxegol whole, it can be crushed and mixed in 4 ounces (120 mL) of water. Drink right away after mixing. Refill the glass with 120 mL of water, stir, and drink.
• Those who have feeding tubes may use this medicine. Use as you have been told. Flush the feeding tube after naloxegol is given.

What do I do if I miss a dose?

• Take a missed dose as soon as you think about it.
• If it is close to the time for your next dose, skip the missed dose and go back to your normal time.
• Do not take 2 doses at the same time or extra doses.

• If your symptoms or health problems do not get better or if they become worse, call your doctor.
• Do not share your drugs with others and do not take anyone else's drugs.
• Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
• Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
• This medicine comes with an extra patient fact sheet called a Medication Guide. Read it with care. Read it again each time this medicine is refilled. If you have any questions about naloxegol, please talk with the doctor, pharmacist, or other health care provider.
• If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

This information should not be used to decide whether or not to take this medicine or any other medicine. Only the healthcare provider has the knowledge and training to decide which medicines are right for a specific patient. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about naloxegol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from the healthcare provider. You must talk with the healthcare provider for complete information about the risks and benefits of using naloxegol.

Review Date: October 4, 2017

• Gastrointestinal Agent, Miscellaneous
• Opioid Antagonist, Peripherally-Acting

Refer to adult dosing.

Adverse events were not observed in animal reproduction studies. However, exposure during pregnancy may potentiate opioid withdrawal in the fetus.

Opioid-Induced Constipation - Chronic:

Initial dose: 25 mg orally once a day
Maintenance dose: 25 mg orally once a day; dose may be reduced to 12.5 mg orally once a day for patients unable to tolerate higher dose

Comments: Prior to initiation, discontinue all maintenance laxative therapy; laxatives can be used as needed for suboptimal response after 3 days.

Use: For the treatment of opioid-induced constipation in adult patients with chronic non-cancer pain.