Mitoxantrone-injection

Name: Mitoxantrone-injection

What are the side effects of mitoxantrone-injection?

The most common side effects of mitoxantrone are:

  • nausea,
  • upper respiratory tract infections,
  • hair loss (alopecia),
  • diarrhea,
  • interruption of menstruation,
  • constipation,
  • inflammation of the mouth (stomatitis).

Other important side effects include

  • heart failure,
  • suppression of the immune system, and
  • liver toxicity.

What is the dosage for mitoxantrone-injection?

Mitoxantrone is given by intravenous infusion. The recommended dose for secondary progressive multiple sclerosis is 12 mg/m2 infusion every 3 months. The lifetime cumulative dose is 140 mg/m2. The dose for nonlymphocytic leukemia is 12 mg/m2/day on days 1-3 with cytarabine 100 mg/m2/day on days 1-7. The dose for hormone-refractory prostate cancer is 12 to 14 mg/m2 every 21 days.

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