Metozolv

Metozolv ODT is a prescription medication used to treat gastroesophageal reflux disease (GERD) when certain other treatments do not work and to relieve symptoms of slow stomach emptying in people with diabetes. 

Metozolv ODT belongs to a group of drugs called prokinetic agents, which speed the movement of food through the digestive system.

This medication comes as an orally disintegrating tablet and is usually taken four times a day, before meals and at bedtime.

Common side effects include headache, nausea, vomiting, tiredness, and sleepiness. 

Metozolv is part of the drug class:

• PROPULSIVES

Metozolv ODT can cause serious side effects, including:

Serious side effects have been reported including:

• Abnormal muscle movements called tardive dyskinesia (TD). These movements happen mostly in the face muscles. You can not control these movements. They may not go away even after stopping Metozolv ODT. There is no treatment for TD, but symptoms may lessen or go away over time after you stop taking Metozolv ODT.

Your chances for getting TD go up:

• the longer you take Metozolv ODT and the more Metozolv ODT you take. You should not take Metozolv ODT for more than 12 weeks.
• if you are older, especially if you are a woman
• if you have diabetes

It is not possible for your doctor to know if you will get TD if you take Metozolv ODT.

Call your doctor right away if you get movements you can not stop or control, such as:

• lip smacking, chewing, or puckering up your mouth
• frowning or scowling
• sticking out your tongue
• blinking and moving your eyes
• shaking of your arms and legs

• Uncontrolled spasms of your face and neck muscles, or muscles of your body, arms, and legs (dystonia). These muscle spasms can cause abnormal movements and body positions. These spasms usually start within the first 2 days of treatment. These spasms happen more often in children and adults under age 30.
• Depression, thoughts about suicide, and suicide. Some people who take Metozolv ODT become depressed. You may have thoughts about hurting or killing yourself. Some people who take Metozolv ODT have ended their own lives (suicide).

• Neuroleptic Malignant Syndrome (NMS). NMS is a very rare but very serious condition that can happen with Metozolv ODT. NMS can cause death and must be treated in a hospital. Symptoms of NMS include: high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and increased sweating.
• Parkinsonism. Symptoms include slight shaking, body stiffness, trouble moving or keeping your balance. If you already have Parkinson's disease, your symptoms may become worse while you are receiving Metozolv ODT.
• High blood pressure. Metozolv ODT can cause your blood pressure to increase. 
• Too much body water. People who have certain liver problems or heart failure and take Metozolv ODT may hold too much water in their body (fluid retention). Tell your doctor right away if you have sudden weight gain, or swelling of your hands, legs, or feet.

Call your doctor and get medical help right away if you:

• feel depressed or have thoughts about hurting or killing yourself
• have high fever, stiff muscles, problems thinking, very fast or uneven heartbeat, and increased sweating
• have muscle movements you cannot stop or control
• have muscle movements that are new or unusual

Do not take Metozolv ODT if you:

• have stomach or intestine problems that could get worse with Metozolv ODT, such as bleeding, blockage or a tear in the stomach or bowel wall
• have an adrenal gland tumor called a pheochromocytoma
• are allergic to metoclopramide or anything in it
• take medicines that can cause uncontrolled movements, such as medicines for mental illness
• have seizures

Do not drink alcohol while taking Metozolv ODT. Alcohol may make some side effects of Metozolv ODT worse, such as feeling sleepy. 

Do not drive, work with machines, or do dangerous tasks until you know how Metozolv ODT affects you. Metozolv ODT may cause sleepiness.

Tell your doctor about all your medical conditions, including if you have:

• depression or mental illness
• Parkinson's disease
• high blood pressure
• kidney problems. Your doctor may start with a lower dose.
• liver problems or heart failure. Metozolv ODT may cause your body to hold fluids.
• heart rhythm problems
• diabetes. Your dose of insulin may need to be changed.
• breast cancer
• drink alcohol
• you are pregnant or plan to become pregnant
• you are breastfeeding or plan to breastfeed

Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Take Metozolv ODT exactly as prescribed. Do not change your dose unless your doctor tells you.

Metozolv ODT comes as a tablet that melts in your mouth. Metozolv ODT is usually taken four times a day (30 minutes before meals and at bedtime). For some patients less frequent dosing may be appropriate. 

• You should not take Metozolv ODT for more than 12 weeks. 

To take Metozolv ODT: 

1. Leave the tablet in the sealed blister Metozolv ODT pack until you are ready to take it. 
2. Use dry hands to open a blister and take out a tablet. If the tablet breaks or crumbles throw it away and take a new tablet out of the blister pack. 
3. Put the tablet on your tongue right away. Let it melt and then swallow. You do not need water to take Metozolv ODT.

If you take too much Metozolv ODT, call your doctor or Poison Control Center.

Take this medication exactly as prescribed by your doctor. Follow the directions on your prescription label carefully.

The dose your doctor recommends may be based on the following:

• the condition being treated
• other medical conditions you have
• other medications you are taking
• your kidney function
• your weight

Metozolv ODT dosing for GERD:

• The usual recommended Metozolv ODT (metoclopramide) dose for the treatment of GERD is 10 mg or 15 mg taken up to four times a day (before meals and at bedtime).

Metozolv ODT is approved for short-term treatment of GERD (up to 12 weeks).

Metozolv ODT dosing for Diabetic Gastroparesis:

• The usual recommended Metozolv ODT (metoclopramide) dose for the treatment of diabetic gastroparesis is 10 mg taken four times a day before meals and at bedtime.
• Treatment may continue for two to eight weeks.
• If severe diabetic gastroparesis symptoms are present, therapy may begin with an injectable form (IM or IV) of metoclopramide.