Methylnaltrexone Tablets

• It is used to treat constipation caused by some pain drugs.

• Tell all of your health care providers that you take this medicine (methylnaltrexone tablets). This includes your doctors, nurses, pharmacists, and dentists.
• Be sure to stay close to a bathroom after you use this medicine. Most people have a stool within a few minutes to a few hours after using it.
• Talk with your doctor before using a laxative with this medicine (methylnaltrexone tablets).
• This medicine is only for use in patients who take pain drugs. Tell your doctor if you stop taking your pain drug.
• Signs of opioid withdrawal have happened with this medicine. Call your doctor right away if you have more sweating, chills, loose stools (diarrhea) or stomach pain that is not normal, anxiety, irritability, or yawning.
• This medicine may not work as well for people who have been taking pain drugs for less than 4 weeks.
• If you are 65 or older, use this medicine (methylnaltrexone tablets) with care. You could have more side effects.
• Tell your doctor if you are pregnant or plan on getting pregnant. You will need to talk about the benefits and risks of using this medicine while you are pregnant.
• If this medicine (methylnaltrexone tablets) is used during pregnancy, it may cause withdrawal in the unborn baby. A doctor will need to check on the unborn baby after this medicine is used.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Belly pain.
• Loose stools (diarrhea).
• Feeling full.
• Headache.
• Muscle spasm.
• Runny nose.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.