Lupron Depot (Leuprolide Injection (Women))

• If you have an allergy to leuprolide or any other part of Lupron Depot (leuprolide injection (women)).
• If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
• If you have unexplained vaginal bleeding.
• If you are pregnant or may be pregnant. Do not take this medicine if you are pregnant.
• If you are breast-feeding. Do not breast-feed while you take Lupron Depot.

This is not a list of all drugs or health problems that interact with this medicine.

Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Lupron Depot with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

• Tell all of your health care providers that you take this medicine. This includes your doctors, nurses, pharmacists, and dentists.
• This medicine may raise some hormone levels in your body during the first few weeks of taking it. Disease signs may get worse before getting better. Tell your doctor if you have any new signs or if your disease signs are worse for longer than a few weeks after starting Lupron Depot.
• This medicine lowers some hormone levels in your body. This may cause some effects like change in breast size, breast soreness or tenderness, testicle changes in men, change in sex ability in men, hot flashes, or sweating. Talk with your doctor.
• Have blood work checked as you have been told by the doctor. Talk with the doctor.
• This medicine may affect certain lab tests. Tell all of your health care providers and lab workers that you take this medicine.
• If you have high blood sugar (diabetes), you will need to watch your blood sugar closely.
• If you smoke, talk with your doctor.
• A very bad pituitary gland problem (pituitary apoplexy) has rarely happened with Lupron Depot. Most of the time, this has happened within 2 weeks after the first dose. Call your doctor right away if you have a sudden headache, throwing up, passing out, mood changes, eye weakness, not able to move your eyes, or change in eyesight.
• This medicine may cause weak bones. This may happen more often if used for a long time. This may raise the chance of broken bones. Call your doctor right away if you have bone pain.
• Have a bone density test as you have been told by your doctor. Talk with your doctor.
• A higher chance of stroke or very bad and sometimes deadly heart problems have been noted with the use of drugs like this medicine in men. The chance is low, but get medical help right away if you have chest pain or pressure, a change in strength on 1 side that is greater than the other, trouble speaking or thinking, change in balance, or change in eyesight.
• Some products are not approved for use in people who are 65 or older or in children. Talk with your doctor.
• Most of the time, Lupron Depot stops you from having a period (menstrual bleeding). This is not a method of birth control. Use a non-hormone type of birth control like condoms to prevent pregnancy while taking this medicine.
• If you miss doses of Lupron Depot, bleeding between cycles can happen. Talk with your doctor.
• This medicine may cause harm to the unborn baby if you take it while you are pregnant.
• A pregnancy test will be done to show that you are NOT pregnant before starting this medicine. If you get pregnant while taking Lupron Depot (leuprolide injection (women)), call your doctor right away.

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

• Headache.
• Feeling tired or weak.
• Not hungry.
• Hard stools (constipation).
• Upset stomach or throwing up.
• Not able to sleep.
• Dizziness.
• Irritation where the shot is given.
• Joint pain.
• Pimples (acne).
• Muscle pain.
• Mood changes.
• A change in weight without trying.
• Feeling nervous and excitable.

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.